Associations between infection intensity categories and morbidity prevalence in school-age children are much stronger for Schistosoma haematobium than for S. mansoni.
Adolescent
Africa South of the Sahara
/ epidemiology
Animals
Chemoprevention
Child
Diarrhea
Female
Humans
Liver
/ parasitology
Male
Morbidity
Parasite Egg Count
Schistosoma haematobium
Schistosoma mansoni
Schistosomiasis haematobia
/ pathology
Schistosomiasis mansoni
/ drug therapy
Urinary Tract
/ parasitology
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
received:
05
01
2021
accepted:
04
05
2021
revised:
07
06
2021
pubmed:
26
5
2021
medline:
14
9
2021
entrez:
25
5
2021
Statut:
epublish
Résumé
World Health Organization (WHO) guidelines for measuring global progress in schistosomiasis control classify individuals with Schistosoma spp. infections based on the concentration of excreted eggs. We assessed the associations between WHO infection intensity categories and morbidity prevalence for selected S. haematobium and S. mansoni morbidities in school-age children. A total of 22,488 children aged 6-15 years from monitoring and evaluation cohorts in Burkina Faso, Mali, Niger, Uganda, Tanzania, and Zambia from 2003-2008 were analyzed using Bayesian logistic regression. Models were utilized to evaluate associations between intensity categories and the prevalence of any urinary bladder lesion, any upper urinary tract lesion, microhematuria, and pain while urinating (for S. haematobium) and irregular hepatic ultrasound image pattern (C-F), enlarged portal vein, laboratory-confirmed diarrhea, and self-reported diarrhea (for S. mansoni) across participants with infection and morbidity data. S. haematobium infection intensity categories possessed consistent morbidity prevalence across surveys for multiple morbidities and participants with light infections had elevated morbidity levels, compared to negative participants. Conversely, S. mansoni infection intensity categories lacked association with prevalence of the morbidity measures assessed. Current status infection intensity categories for S. haematobium were associated with morbidity levels in school-age children, suggesting urogenital schistosomiasis morbidity can be predicted by an individual's intensity category. Conversely, S. mansoni infection intensity categories were not consistently indicative of childhood morbidity at baseline or during the first two years of a preventive chemotherapy control program.
Sections du résumé
BACKGROUND
World Health Organization (WHO) guidelines for measuring global progress in schistosomiasis control classify individuals with Schistosoma spp. infections based on the concentration of excreted eggs. We assessed the associations between WHO infection intensity categories and morbidity prevalence for selected S. haematobium and S. mansoni morbidities in school-age children.
METHODOLOGY
A total of 22,488 children aged 6-15 years from monitoring and evaluation cohorts in Burkina Faso, Mali, Niger, Uganda, Tanzania, and Zambia from 2003-2008 were analyzed using Bayesian logistic regression. Models were utilized to evaluate associations between intensity categories and the prevalence of any urinary bladder lesion, any upper urinary tract lesion, microhematuria, and pain while urinating (for S. haematobium) and irregular hepatic ultrasound image pattern (C-F), enlarged portal vein, laboratory-confirmed diarrhea, and self-reported diarrhea (for S. mansoni) across participants with infection and morbidity data.
PRINCIPAL FINDINGS
S. haematobium infection intensity categories possessed consistent morbidity prevalence across surveys for multiple morbidities and participants with light infections had elevated morbidity levels, compared to negative participants. Conversely, S. mansoni infection intensity categories lacked association with prevalence of the morbidity measures assessed.
CONCLUSIONS/SIGNIFICANCE
Current status infection intensity categories for S. haematobium were associated with morbidity levels in school-age children, suggesting urogenital schistosomiasis morbidity can be predicted by an individual's intensity category. Conversely, S. mansoni infection intensity categories were not consistently indicative of childhood morbidity at baseline or during the first two years of a preventive chemotherapy control program.
Identifiants
pubmed: 34033646
doi: 10.1371/journal.pntd.0009444
pii: PNTD-D-21-00023
pmc: PMC8183985
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0009444Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Am J Trop Med Hyg. 1988 Oct;39(4):361-8
pubmed: 3142286
Int J Parasitol. 2016 Jun;46(7):395-404
pubmed: 27063073
Am J Trop Med Hyg. 2012 Nov;87(5):874-82
pubmed: 22987651
Parasitol Res. 2015 Apr;114(4):1279-89
pubmed: 25711148
Trans R Soc Trop Med Hyg. 1984;78(6):752-4
pubmed: 6335929
Acta Trop. 2003 May;86(2-3):125-39
pubmed: 12745133
Parasitology. 2009 Nov;136(13):1731-7
pubmed: 19631007
Acta Trop. 1997 Dec;68(3):347-56
pubmed: 9492919
PLoS Negl Trop Dis. 2014 Apr 17;8(4):e2807
pubmed: 24743389
World Health Organ Tech Rep Ser. 2002;912:i-vi, 1-57, back cover
pubmed: 12592987
Chronic Illn. 2008 Mar;4(1):65-79
pubmed: 18322031
PLoS Negl Trop Dis. 2010 Nov 02;4(11):e867
pubmed: 21072229
Trop Med Int Health. 2001 Sep;6(9):699-706
pubmed: 11555437
World J Urol. 2012 Feb;30(1):31-8
pubmed: 21909645
Trans R Soc Trop Med Hyg. 1998 Jul-Aug;92(4):451-3
pubmed: 9850407
Front Med (Lausanne). 2018 Aug 10;5:223
pubmed: 30159314
Am J Trop Med Hyg. 2018 Oct;99(4):1011-1017
pubmed: 30141396
Am J Trop Med Hyg. 2006 Dec;75(6):1042-52
pubmed: 17172363
J Infect Dis. 2002 Jun 1;185(11):1644-9
pubmed: 12023771
Am J Trop Med Hyg. 1998 Jul;59(1):150-4
pubmed: 9684644
Am J Trop Med Hyg. 2015 May;92(5):952-8
pubmed: 25758651
Bull World Health Organ. 2000;78(3):389-98
pubmed: 10812739
Lancet. 2014 Jun 28;383(9936):2253-64
pubmed: 24698483
J Pediatr Urol. 2007 Oct;3(5):364-8
pubmed: 18947774
Am J Trop Med Hyg. 1991 Apr;44(4):444-51
pubmed: 1904198
Am J Trop Med Hyg. 2015 Aug;93(2):371-6
pubmed: 26013375
J Epidemiol Community Health. 2004 Aug;58(8):635-41
pubmed: 15252064
N Engl J Med. 2019 Dec 26;381(26):2519-2528
pubmed: 31881138
Parasitology. 2001 May;122(Pt 5):537-44
pubmed: 11393827
Mem Inst Oswaldo Cruz. 2010 Jul;105(4):409-13
pubmed: 20721483
Acta Trop. 1992 May;51(1):85-8
pubmed: 1351357
Am J Trop Med Hyg. 2004 Jul;71(1):98-106
pubmed: 15238697
Parasite Epidemiol Control. 2018 Nov 23;4:e00077
pubmed: 30662962
Parasitology. 2009 Nov;136(13):1719-30
pubmed: 19631008
PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2431
pubmed: 24069486
Am J Trop Med Hyg. 1994 May;50(5):575-9
pubmed: 8203706
Trop Med Int Health. 2004 Apr;9(4):461-70
pubmed: 15078264
Parasitol Res. 2014 Nov;113(11):3915-25
pubmed: 25260691
Parasitology. 2014 Dec;141(14):1947-61
pubmed: 25158604
Lancet. 2005 Apr 30-May 6;365(9470):1561-9
pubmed: 15866310
PLoS Negl Trop Dis. 2015 Feb 19;9(2):e0003504
pubmed: 25695740
Trends Parasitol. 2006 Jul;22(7):332-9
pubmed: 16713357
Am J Trop Med Hyg. 1997 Sep;57(3):337-41
pubmed: 9311646
Bull World Health Organ. 2008 Oct;86(10):780-7, A
pubmed: 18949215
Bull World Health Organ. 2007 Feb;85(2):91-9
pubmed: 17308729
J Infect Dis. 2007 Sep 1;196(5):659-69
pubmed: 17674306
Am J Trop Med Hyg. 2021 Jan 11;:
pubmed: 33432910
Trop Med Int Health. 2003 Feb;8(2):109-17
pubmed: 12581434
Acta Trop. 2003 May;86(2-3):161-83
pubmed: 12745135
Trans R Soc Trop Med Hyg. 2004 Feb;98(2):125-36
pubmed: 14964813
Am J Trop Med Hyg. 1992 Apr;46(4):409-15
pubmed: 1575287