Hepatitis C virus modulates signal peptide peptidase to alter host protein processing.

Animals Antigen Presentation / immunology Aspartic Acid Endopeptidases / metabolism Cell Line Down-Regulation Hepacivirus / immunology Histocompatibility Antigens Class I / immunology Humans Immune Evasion / physiology Mice Viral Core Proteins / physiology

HCV MHC class I antigen presentation signal peptide peptidase

Journal

Proceedings of the National Academy of Sciences of the United States of America

ISSN: 1091-6490

Titre abrégé: Proc Natl Acad Sci U S A

Pays: United States

ID NLM: 7505876

Informations de publication

Date de publication:
01 06 2021

Historique:

entrez: 26 5 2021

pubmed: 27 5 2021

medline: 15 12 2021

Statut: ppublish

Résumé

Immunoevasins are viral proteins that prevent antigen presentation on major histocompatibility complex (MHC) class I, thus evading host immune recognition. Hepatitis C virus (HCV) evades immune surveillance to induce chronic infection; however, how HCV-infected hepatocytes affect immune cells and evade immune recognition remains unclear. Herein, we demonstrate that HCV core protein functions as an immunoevasin. Its expression interfered with the maturation of MHC class I molecules catalyzed by the signal peptide peptidase (SPP) and induced their degradation via HMG-CoA reductase degradation 1 homolog, thereby impairing antigen presentation to CD8

Identifiants

DOI: 10.1073/pnas.2026184118 PMID: 34035171 PMC: PMC8179148

pubmed: 34035171

pii: 2026184118

doi: 10.1073/pnas.2026184118

pmc: PMC8179148

pii:

doi:

Substances chimiques

Histocompatibility Antigens Class I 0

Viral Core Proteins 0

Aspartic Acid Endopeptidases EC 3.4.23.-

signal peptide peptidase EC 3.4.23.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

The authors declare no competing interest.

Références

PLoS Pathog. 2010 Sep 09;6(9):e1001098

pubmed: 20844579

Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12384-9

pubmed: 9356458

J Virol. 2014 Nov;88(22):13352-66

pubmed: 25210167

J Virol. 2019 Nov 13;93(23):

pubmed: 31511378

PLoS One. 2014 Jan 20;9(1):e85360

pubmed: 24465545

EMBO J. 1997 Nov 17;16(22):6636-45

pubmed: 9362478

Immunity. 1997 May;6(5):613-21

pubmed: 9175839

J Virol. 2008 Sep;82(17):8349-61

pubmed: 18562515

Best Pract Res Clin Gastroenterol. 2012 Aug;26(4):401-12

pubmed: 23199500

Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8381-5

pubmed: 10890896

Eur J Immunol. 2016 Sep;46(9):2204-10

pubmed: 27296288

Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1896-901

pubmed: 9050876

J Gastrointestin Liver Dis. 2007 Mar;16(1):65-73

pubmed: 17410291

EMBO J. 1998 Apr 15;17(8):2186-95

pubmed: 9545232

Proc Natl Acad Sci U S A. 2002 Apr 30;99(9):5931-6

pubmed: 11983893

J Immunol. 2007 Nov 1;179(9):5717-27

pubmed: 17947644

J Immunol. 1999 May 1;162(9):5049-52

pubmed: 10227971

EMBO J. 2014 Nov 3;33(21):2492-506

pubmed: 25239945

J Biol Chem. 2015 Jul 17;290(29):17879-17893

pubmed: 26048985

Nat Commun. 2016 Jun 10;7:11786

pubmed: 27283361

J Hepatol. 2014 Nov;61(1 Suppl):S14-25

pubmed: 25443342

J Immunol. 2001 Dec 1;167(11):6441-6

pubmed: 11714810

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14290-5

pubmed: 23929775

J Cell Biol. 2014 Jun 23;205(6):847-62

pubmed: 24958774

Immunity. 2001 Oct;15(4):627-36

pubmed: 11672544

Reumatismo. 2002 Jul-Sep;54(3):266-71

pubmed: 12404037

J Hepatol. 2017 May;66(5):888-896

pubmed: 28040549

Annu Rev Immunol. 2005;23:225-74

pubmed: 15771571

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):E10782-E10791

pubmed: 29187532

J Cell Biol. 2007 May 21;177(4):613-24

pubmed: 17502423

J Cell Biol. 2009 Sep 7;186(5):685-92

pubmed: 19720873

Int J Med Sci. 2006;3(2):47-52

pubmed: 16614742

J Hepatol. 2016 Oct;65(4):727-733

pubmed: 27349488

Gastroenterol Hepatol (N Y). 2011 Mar;7(3):154-62

pubmed: 21528041

J Biol Chem. 2006 May 26;281(21):14622-31

pubmed: 16567808

J Clin Invest. 2011 Aug;121(8):3343-56

pubmed: 21747166

Cell Rep. 2015 Oct 13;13(2):223-33

pubmed: 26440898

Nat Rev Microbiol. 2013 Jul;11(7):482-96

pubmed: 23748342

Nature. 1995 Jun 1;375(6530):415-8

pubmed: 7760936

Int J Exp Pathol. 2006 Aug;87(4):317-24

pubmed: 16875497

Proc Natl Acad Sci U S A. 2011 Feb 1;108(5):2034-9

pubmed: 21245296

Nat Methods. 2014 Aug;11(8):783-784

pubmed: 25075903

Proc Natl Acad Sci U S A. 2016 Aug 2;113(31):8825-30

pubmed: 27439867

Mol Immunol. 2014 Jan;57(1):44-51

pubmed: 23993278

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6904-9

pubmed: 9192664

Nature. 2006 Jun 15;441(7095):894-7

pubmed: 16738546

Clin Exp Immunol. 1989 Jun;76(3):446-51

pubmed: 2787717

Int Immunol. 2001 Aug;13(8):1063-73

pubmed: 11470776

Proc Natl Acad Sci U S A. 2014 Aug 5;111(31):11425-30

pubmed: 25030448

Proc Natl Acad Sci U S A. 2008 Mar 18;105(11):4370-5

pubmed: 18334634

Nat Commun. 2016 May 04;7:11379

pubmed: 27142248

Biochim Biophys Acta. 2009 Jan;1794(1):14-22

pubmed: 18930168

Nature. 1995 Jun 22;375(6533):685-8

pubmed: 7540727

J Gen Virol. 1997 Jul;78 ( Pt 7):1527-31

pubmed: 9225025

J Cell Biol. 2004 Dec 6;167(5):903-13

pubmed: 15569716

Int J Biochem Cell Biol. 2008;40(8):1437-42

pubmed: 18321762

Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9572-7

pubmed: 9689122