High glucose: an emerging association between diabetes mellitus and cancer progression.
Animals
Antineoplastic Agents
/ therapeutic use
Biomarkers
/ blood
Blood Glucose
/ drug effects
Diabetes Mellitus
/ blood
Disease Progression
Energy Metabolism
/ drug effects
Humans
Hypoglycemic Agents
/ therapeutic use
Neoplasms
/ blood
Prognosis
Risk Factors
Tumor Microenvironment
Warburg Effect, Oncologic
Cancer metabolism
Cancer progression
Diabetes mellitus
High glucose
Warburg effect
Journal
Journal of molecular medicine (Berlin, Germany)
ISSN: 1432-1440
Titre abrégé: J Mol Med (Berl)
Pays: Germany
ID NLM: 9504370
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
05
10
2020
accepted:
18
05
2021
revised:
16
04
2021
pubmed:
27
5
2021
medline:
9
2
2022
entrez:
26
5
2021
Statut:
ppublish
Résumé
The association of cancer and diabetes mellitus (DM) has been studied for decades. Hyperglycemia and the imbalance of hormones are factors that contribute to the molecular link between DM and carcinogenesis and cancer progression. Hyperglycemia alone or in combination with hyperinsulinemia are key factors that promote cancer aggressiveness. Many preclinical studies suggest that high glucose induces abnormal energy metabolism and aggressive cancer via several mechanisms. As evidenced by clinical studies, hyperglycemia is associated with poor clinical outcomes in patients who have comorbid DM. The prognoses of cancer patients with DM are improved when their plasma glucose levels are controlled. This suggests that high glucose level maybe be involved in the molecular mechanism that causes the link between DM and cancer and may also be useful for prognosis of cancer progression. This review comprehensively summarizes the evidence from recent pre-clinical and clinical studies of the impact of hyperglycemia on cancer advancement as well as the underlying molecular mechanism for this impact. Awareness among clinicians of the association between hyperglycemia or DM and cancer progression may improve cancer treatment outcome in patients who have DM.
Identifiants
pubmed: 34036430
doi: 10.1007/s00109-021-02096-w
pii: 10.1007/s00109-021-02096-w
doi:
Substances chimiques
Antineoplastic Agents
0
Biomarkers
0
Blood Glucose
0
Hypoglycemic Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1175-1193Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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