Non-scarring patchy alopecia: What else, apart from alopecia areata?

alopecia areata marginal zone lymphoma non-scarring alopecia patchy alopecia systemic lymphoma

Journal

Journal of cutaneous pathology
ISSN: 1600-0560
Titre abrégé: J Cutan Pathol
Pays: United States
ID NLM: 0425124

Informations de publication

Date de publication:
Oct 2021
Historique:
revised: 13 05 2021
received: 24 01 2021
accepted: 15 05 2021
pubmed: 27 5 2021
medline: 1 2 2022
entrez: 26 5 2021
Statut: ppublish

Résumé

A 67-year-old woman presented with a 3-month history of patchy alopecia areata (AA)-like hair loss and multiple painful enlarged lymph nodes at cervical, nuchal, and left axillary site. The patient was on follow-up for IgM monoclonal gammopathy of undetermined significance, stable for many years. A punch biopsy from a patch of the temporal scalp revealed the presence of B-cell lymphoid infiltrates consistent with marginal zone B-cell lymphoma (MZL). Other staging examinations were conducted to make a definitive diagnosis of nodal MZL with secondary cutaneous involvement. The patient showed a complete remission of the alopecia, without evidence of scarring, after immunochemotherapy for lymphoma.

Identifiants

pubmed: 34036615
doi: 10.1111/cup.14068
doi:

Types de publication

Case Reports

Langues

eng

Sous-ensembles de citation

IM

Pagination

1282-1285

Informations de copyright

© 2021 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Références

Baykal C, Erdem S, Kilic S, et al. Epidermotropic skin involvement of splenic marginal zone B-cell lymphoma: a diagnostic challenge. J Cutan Pathol. 2017;44(3):312-314.
Zinzani PL. The many faces of marginal zone lymphoma. Hematology Am Soc Hematol Educ Program. 2012;2012(1):426-432.
Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood. 2016;127(20):2375-2390.
Gerami P, Wickless SC, Querfeld C, Rosen ST, Kuzel TM, Guitart J. Cutaneous involvement with marginal zone lymphoma. J Am Acad Dermatol. 2010;63(1):142-145.
Chiou CC, Kuo SC. Bilateral auricular swelling: marginal zone lymphoma with cutaneous involvement. Cutis. 2015;96(2):E7-E8.
van Maldegem F, van Dijk R, Wormhoudt TAM, et al. The majority of cutaneous marginal zone B-cell lymphomas expresses class-switched immunogloblins and develops in a T-helper type 2 inflammatory environment. Blood. 2008;112(8):3355-3361.
Edinger JT, Kant JA, Swerdlow SH. Cutaneous marginal zone lymphomas have distinctive features and include 2 subsets. Am J Surg Pathol. 2010;34(12):1830-1841.
Miteva M, El Shabrawi-Caelen L, Fink-Puches R, et al. Alopecia universalis associated with cutaneous T cell lymphoma. Dermatology. 2014;229(2):65-69.
Amin SM, Tan T, Guitart J, Colavincenzo M, Gerami P, Yazdan P. CD8+ mycosis fungoides clinically masquerading as alopecia areata. J Cutan Pathol. 2016;43(12):1179-1182.
Massone C, Fink-Puches R, Cerroni L. Atypical clinical presentation of primary and secondary cutaneous follicle center lymphoma (FCL) on the head characterized by macular lesions. J Am Acad Dermatol. 2016;75(5):1000-1006.

Auteurs

Luigi Pisano (L)

Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Raffaella Santi (R)

Division of Pathological Anatomy, Department of Health Sciences, University of Florence, Florence, Italy.

Vieri Grandi (V)

Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.
St John's Institute of Dermatology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Alberto Bosi (A)

Division of Hematology, Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Marco Santucci (M)

Division of Pathological Anatomy, Department of Health Sciences, University of Florence, Florence, Italy.

Nicola Pimpinelli (N)

Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

Elisa Margherita Difonzo (EM)

Dermatology Unit, Department of Health Sciences, University of Florence, Florence, Italy.

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