Visualizing the Dynamic Metalation State of New Delhi Metallo-β-lactamase-1 in Bacteria Using a Reversible Fluorescent Probe.


Journal

Journal of the American Chemical Society
ISSN: 1520-5126
Titre abrégé: J Am Chem Soc
Pays: United States
ID NLM: 7503056

Informations de publication

Date de publication:
09 06 2021
Historique:
pubmed: 27 5 2021
medline: 30 12 2021
entrez: 26 5 2021
Statut: ppublish

Résumé

New Delhi metallo-β-lactamase (NDM) grants resistance to a broad spectrum of β-lactam antibiotics, including last-resort carbapenems, and is emerging as a global antibiotic resistance threat. Limited zinc availability adversely impacts the ability of NDM-1 to provide resistance, but a number of clinical variants have emerged that are more resistant to zinc scarcity (e.g., NDM-15). To provide a novel tool to better study metal ion sequestration in host-pathogen interactions, we describe the development of a fluorescent probe that reports on the dynamic metalation state of NDM within

Identifiants

pubmed: 34038127
doi: 10.1021/jacs.1c00290
pmc: PMC8230704
mid: NIHMS1710803
doi:

Substances chimiques

Chelating Agents 0
Enzyme Inhibitors 0
Fluorescent Dyes 0
Sulfhydryl Compounds 0
beta-Lactamases EC 3.5.2.6
beta-lactamase NDM-1 EC 3.5.2.6
Zinc J41CSQ7QDS

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

8314-8323

Subventions

Organisme : NIGMS NIH HHS
ID : R01 GM111926
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133612
Pays : United States
Organisme : NIH HHS
ID : S10 OD021508
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM134454
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM134047
Pays : United States

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Auteurs

Radhika Mehta (R)

Department of Chemistry, University of Texas at Austin, 105 East 24th Street Stop A5300, Austin, Texas 78712, United States.

Dann D Rivera (DD)

Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States.

David J Reilley (DJ)

Department of Chemistry and Biochemistry, University of California-Los Angeles, 607 Charles E. Young Drive, Los Angeles, California 90095-1569, United States.

Dominique Tan (D)

Department of Chemistry, University of Texas at Austin, 105 East 24th Street Stop A5300, Austin, Texas 78712, United States.

Pei W Thomas (PW)

Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States.

Abigail Hinojosa (A)

Department of Chemistry, University of Texas at Austin, 105 East 24th Street Stop A5300, Austin, Texas 78712, United States.

Alesha C Stewart (AC)

Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States.

Zishuo Cheng (Z)

Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.

Caitlyn A Thomas (CA)

Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.

Michael W Crowder (MW)

Department of Chemistry and Biochemistry, Miami University, Oxford, Ohio 45056, United States.

Anastassia N Alexandrova (AN)

Department of Chemistry and Biochemistry, University of California-Los Angeles, 607 Charles E. Young Drive, Los Angeles, California 90095-1569, United States.

Walter Fast (W)

Division of Chemical Biology & Medicinal Chemistry, College of Pharmacy, University of Texas, Austin, Texas 78712, United States.

Emily L Que (EL)

Department of Chemistry, University of Texas at Austin, 105 East 24th Street Stop A5300, Austin, Texas 78712, United States.

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Classifications MeSH