Oxaloacetate treatment preserves motor function in SOD1

Amyotrophic Lateral Sclerosis / metabolism Animals Disease Models, Animal Inflammation / drug therapy Longevity / drug effects Mice Motor Activity / drug effects Motor Neurons / drug effects Oxaloacetic Acid / pharmacology Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism Spinal Cord / drug effects Superoxide Dismutase / metabolism Tumor Necrosis Factor-alpha / metabolism

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
26 05 2021
Historique:
received: 18 04 2018
accepted: 07 05 2021
entrez: 27 5 2021
pubmed: 28 5 2021
medline: 3 11 2021
Statut: epublish

Résumé

Amyotrophic lateral sclerosis (ALS) remains a devastating motor neuron disease with limited treatment options. Oxaloacetate treatment has a neuroprotective effect in rodent models of seizure and neurodegeneration. Therefore, we treated the ALS model superoxide dismutase 1 (SOD1)

Identifiants

DOI: 10.1038/s41598-021-90438-6 PMID: 34040085 PMC: PMC8155202
pubmed: 34040085
doi: 10.1038/s41598-021-90438-6
pii: 10.1038/s41598-021-90438-6
pmc: PMC8155202
doi:

Substances chimiques

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha 0
Ppargc1a protein, mouse 0
Tumor Necrosis Factor-alpha 0
Oxaloacetic Acid 2F399MM81J
Superoxide Dismutase EC 1.15.1.1

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

11051

Subventions

Organisme : NCRR NIH HHS
ID : P20 RR016475
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG051470
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM103418
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM104936
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD090216
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS078214
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG035982
Pays : United States

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Auteurs

Sudheer K Tungtur (SK)

Department of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Cardiovascular Division, University of Minnesota School of Medicine, Minneapolis, MN, 55455, USA.

Heather M Wilkins (HM)

Department of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.

Robert S Rogers (RS)

Department of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Department of Curriculum and Integrative Learning, Kansas City University, Joplin, MO, 64804, USA.

Yomna Badawi (Y)

Department of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Department of Neuroscience, University of Pittsburgh, Pittsburgh, PA, 15260, USA.

Jessica M Sage (JM)

Department of Basic Sciences, Kansas City University, Kansas City, MO, 64106, USA.

Abdulbaki Agbas (A)

Department of Basic Sciences, Kansas City University, Kansas City, MO, 64106, USA.

Omar Jawdat (O)

Department of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.

Richard J Barohn (RJ)

Department of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.
Department of Neurology, University Missouri-Columbia, Columbia, MO, 65212, USA.

Russell H Swerdlow (RH)

Department of Neurology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA.

Hiroshi Nishimune (H)

Department of Anatomy and Cell Biology, School of Medicine, University of Kansas, Kansas City, KS, 66160, USA. nishimun@tmig.or.jp.
Tokyo Metropolitan Institute of Gerontology, Neurobiology of Aging, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan. nishimun@tmig.or.jp.

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Classifications MeSH

questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Troubles de l'homéostasie des protéines › Protéinopathies TDP-43 › Sclérose latérale amyotrophique › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Eucaryotes › Animaux › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Phénomènes physiologiques › Longévité › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système locomoteur › Mouvement › Activité motrice › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Cellules › Neurones › Neurones efférents › Motoneurones › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Cétoacides › Oxaloacétates › Acide oxaloacétique › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Coactivateurs de récepteurs nucléaires › Coactivateur 1-alpha du récepteur gamma activé par les proliférateurs de peroxysomes › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Oxaloacetate treatment preserves motor function in SOD1
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Facteur de nécrose tumorale alpha › Oxaloacetate treatment preserves motor function in SOD1