Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing's disease.

Adenoma Corticotropin-Releasing Hormone Humans Interleukin-6 Matrix Metalloproteinase 9 Petrosal Sinus Sampling Pituitary ACTH Hypersecretion Pituitary Apoplexy Pituitary Neoplasms Retrospective Studies
CRH Cushing's disease IL-6 MMP9 Pituitary apoplexy

Journal

Pituitary
ISSN: 1573-7403
Titre abrégé: Pituitary
Pays: United States
ID NLM: 9814578

Informations de publication

Date de publication:
Dec 2021
Historique:
accepted: 17 05 2021
pubmed: 28 5 2021
medline: 18 1 2022
entrez: 27 5 2021
Statut: ppublish

Résumé

Pituitary apoplexy is a rare endocrine emergency. The purpose of this study is to characterize physiological changes involved in pituitary apoplexy, especially during the acute phase. A Cushing's disease patient experienced corticotroph releasing hormone (CRH)-induced pituitary apoplexy during inferior petrosal sinus sampling (IPSS). The IPSS blood samples from the Cushing's disease patient were retrospectively analyzed for cytokine markers. For comparison, we also analyzed cytokine markers in blood samples from two pituitary ACTH-secreting microadenoma patients and one patient with an ectopic ACTH-secreting tumor. Acute elevation of interleukin 6 (IL-6) and matrix metalloproteinase 9 (MMP9) was observed in the IPSS blood sample on the apoplectic hemorrhagic site of the tumor. In contrast, such a change was not observed in the blood samples from the contralateral side of the apoplexy patient and in other IPSS samples from two non-apoplexy Cushing's disease patient and a patient with ectopic Cushing's syndrome. IL-6 and MMP9 may be involved in the acute process of pituitary apoplexy in Cushing's disease.

Identifiants

DOI: 10.1007/s11102-021-01157-0 PMID: 34041660 PMC: PMC8551006
pubmed: 34041660
doi: 10.1007/s11102-021-01157-0
pii: 10.1007/s11102-021-01157-0
pmc: PMC8551006
mid: NIHMS1722466
doi:

Substances chimiques

IL6 protein, human 0
Interleukin-6 0
Corticotropin-Releasing Hormone 9015-71-8
MMP9 protein, human EC 3.4.24.35
Matrix Metalloproteinase 9 EC 3.4.24.35

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

859-866

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR064195
Pays : United States
Organisme : National Institute of Child Health and Human Development
ID : R01AR064195
Organisme : Graduate School, University of Minnesota
ID : UMF0011528
Organisme : Graduate School, University of Minnesota
ID : AHC Grant-in-Aid 212588

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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Auteurs

Takako Araki (T)

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA. taraki@umn.edu.
ORCID: 0000-0002-4451-1668

Jutarat Sangtian (J)

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.

Darin Ruanpeng (D)

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.

Ramachandra Tummala (R)

Department of Neurosurgery, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.

Brent Clark (B)

Department of Laboratory Medicine and Pathology, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.

Lynn Burmeister (L)

Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, 516 Delaware Street, SE, Minneapolis, MN, 55455, USA.

Daniel Peterson (D)

Special Chemistry Laboratory, University of Minnesota Fairview Clinic, 500 SE Harvard St., Minneapolis, MN, 55455, USA.

Andrew S Venteicher (AS)

Department of Neurosurgery, University of Minnesota, 500 SE Harvard St., Minneapolis, MN, 55455, USA.

Yasuhiko Kawakami (Y)

Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St. SE., 6-160 Jackson Hall, Minneapolis, MN, 55455, USA.
Stem Cell Institute, University of Minnesota, 2001 6th Street SE, Minneapolis, MN, 55455, USA.

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Classifications MeSH

questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Adénomes › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de tissu nerveux › Neuropeptides › Hormones hypothalamiques › Hormones hypophysiotropes libératrices › Corticolibérine › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-6 › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Secreted matrix metalloproteinases › Matrix metalloproteinase 9 › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Techniques d'investigation › Techniques de laboratoire clinique › Manipulation d'échantillons › Prélèvement d'échantillon sanguin › Cathétérisme des sinus pétreux › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Hyperpituitarisme › Hypersécrétion hypophysaire d'ACTH › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Apoplexie hypophysaire › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Maladies endocriniennes › Maladies de l'hypophyse › Tumeurs de l'hypophyse › Acute elevation of interleukin 6 and matrix...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Acute elevation of interleukin 6 and matrix...