Longitudinal Blood Pressure Patterns From Mid- to Late Life and Late-Life Hearing Loss in the Atherosclerosis Risk in Communities Study.

Aged Antihypertensive Agents / therapeutic use Atherosclerosis / complications Blood Pressure Hearing Loss / complications Humans Hypertension / complications Prospective Studies
Cardiovascular Epidemiology Risk factors Sensory

Journal

The journals of gerontology. Series A, Biological sciences and medical sciences
ISSN: 1758-535X
Titre abrégé: J Gerontol A Biol Sci Med Sci
Pays: United States
ID NLM: 9502837

Informations de publication

Date de publication:
03 03 2022
Historique:
received: 18 01 2021
pubmed: 28 5 2021
medline: 19 4 2022
entrez: 27 5 2021
Statut: ppublish

Résumé

Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up. Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression. Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing. Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.

Sections du résumé

BACKGROUND
Hearing loss is prevalent and associated with adverse functional outcomes in older adults. Prevention thus has far-reaching implications, yet few modifiable risk factors have been identified. Hypertension may contribute to age-related hearing loss, but epidemiologic evidence is mixed. We studied a prospective cohort of 3343 individuals from the Atherosclerosis Risk in Communities study, aged 44-65 years at baseline with up to 30 years of follow-up.
METHODS
Hearing was assessed in late life (2016-2017) using a better-ear audiometric pure tone average (0.5, 1, 2, 4 kHz) and the Quick Speech-in-Noise (QuickSIN) test. Hypertension was defined as systolic blood pressure ≥140 mmHg, diastolic blood pressure ≥90 mmHg, or antihypertensive medication use. Midlife hypertension was defined by hypertension at 2 consecutive visits between 1987-1989 and 1996-1998. Late-life hypertension was defined in 2016-2017. Late-life low blood pressure was defined as a systolic blood pressure less than 90 mmHg or diastolic blood pressure less than 60 mmHg, irrespective of antihypertensive medication use. Associations between blood pressure patterns from mid- to late life and hearing outcomes were assessed using multivariable-adjusted linear regression.
RESULTS
Compared to persistent normotension, persistent hypertension from mid- to late life was associated with worse central auditory processing (difference in QuickSIN score = -0.66 points, 95% CI: -1.14, -0.17) but not with audiometric hearing.
CONCLUSIONS
Participants with persistent hypertension had poorer late-life central auditory processing. These findings suggest that hypertension may be more strongly related to hearing-related changes in the brain than in the cochlea.

Identifiants

DOI: 10.1093/gerona/glab153 PMID: 34043799 PMC: PMC8893194
pubmed: 34043799
pii: 6286936
doi: 10.1093/gerona/glab153
pmc: PMC8893194
doi:

Substances chimiques

Antihypertensive Agents 0

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

640-646

Subventions

Organisme : NHLBI NIH HHS
Pays : United States
Organisme : NIDCD NIH HHS
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG027668
Pays : United States
Organisme : NINDS NIH HHS
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700001I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700002I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700005I
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201700004I
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096812
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096814
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096899
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096902
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL096917
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL070825
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG054693
Pays : United States
Organisme : NIA NIH HHS
ID : K23 AG065443
Pays : United States

Informations de copyright

© The Author(s) 2021. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Auteurs

James Ting (J)

Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Kening Jiang (K)

Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
ORCID: 0000-0002-4532-4469

Simo Du (S)

Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Joshua Betz (J)

Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Nicholas Reed (N)

Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Melinda C Power (MC)

Department of Epidemiology and Biostatistics, Milken Institute School of Public Health, George Washington University, District of Columbia, USA.

Rebecca Gottesman (R)

Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.

A Richey Sharrett (AR)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

Michael Griswold (M)

Department of Data Science, The University of Mississippi Medical Center, Jackson, USA.

Keenan A Walker (KA)

Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute on Aging, Baltimore, Maryland, USA.

Edgar R Miller (ER)

Department of Medicine, Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Institute for Clinical and Translational Research, Johns Hopkins University, Baltimore, Maryland, USA.

Frank R Lin (FR)

Department of Otolaryngology-Head & Neck Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.

Jennifer A Deal (JA)

Cochlear Center for Hearing and Public Health, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Longitudinal Blood Pressure Patterns From Mid-...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents cardiovasculaires › Antihypertenseurs › Longitudinal Blood Pressure Patterns From Mid-...
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questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Longitudinal Blood Pressure Patterns From Mid-...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Troubles sensitifs › Troubles de l'audition › Perte d'audition › Longitudinal Blood Pressure Patterns From Mid-...
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questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Longitudinal Blood Pressure Patterns From Mid-...
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