Drugs for preventing postoperative nausea and vomiting in adults after general anesthesia: An abridged Cochrane network meta-analysis.
antiemetics
network meta-analysis
postoperative nausea and vomiting
systematic review
vomiting
Journal
Journal of evidence-based medicine
ISSN: 1756-5391
Titre abrégé: J Evid Based Med
Pays: England
ID NLM: 101497477
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
revised:
08
02
2021
received:
18
12
2020
accepted:
10
04
2021
pubmed:
28
5
2021
medline:
29
10
2021
entrez:
27
5
2021
Statut:
ppublish
Résumé
In this abridged version of the recently published Cochrane review on antiemetic drugs, we summarize its most important findings and discuss the challenges and the time needed to prepare what is now the largest Cochrane review with network meta-analysis in terms of the number of included studies and pages in its full printed form. We conducted a systematic review with network meta-analyses to compare and rank single antiemetic drugs and their combinations belonging to 5HT₃-, D₂-, NK₁-receptor antagonists, corticosteroids, antihistamines, and anticholinergics used to prevent postoperative nausea and vomiting in adults after general anesthesia. 585 studies (97 516 participants) testing 44 single drugs and 51 drug combinations were included. The studies' overall risk of bias was assessed as low in only 27% of the studies. In 282 studies, 29 out of 36 drug combinations and 10 out of 28 single drugs lowered the risk of vomiting at least 20% compared to placebo. In the ranking of treatments, combinations of drugs were generally more effective than single drugs. Single NK There is high or moderate evidence for at least seven single drugs preventing postoperative vomiting. However, there is still considerable lack of evidence regarding safety aspects that does warrant investigation.
Substances chimiques
Antiemetics
0
Pharmaceutical Preparations
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
188-197Informations de copyright
© 2021 The Authors. Journal of Evidence-Based Medicine published by Chinese Cochrane Center, West China Hospital of Sichuan University and John Wiley & Sons Australia, Ltd.
Références
UpToDate. Postoperative nausea and vomiting. Available at https://www.uptodate.com/contents/postoperative-nausea-and-vomiting (accessed July 24/2020).
Apfel CC, Kranke P, Katz MH, et al. Volatile anaesthetics may be the main cause of early but not delayed postoperative vomiting: a randomized controlled trial of factorial design. Br J Anaesth. 2002;88:659-668.
Apfel CC, Laara E, Koivuranta M, Greim CA, Roewer N. A simplified risk score for predicting postoperative nausea and vomiting: conclusions from cross-validations between two centers. Anesthesiology. 1999;91:693-700.
Gan TJ, Belani KG, Bergese S, et al. Fourth consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2020;131:411-448.
Gan TJ, Diemunsch P, Habib AS, et al. Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2014;118:85-113.
Gan T, Sloan F, Dear Gde L, El-Moalem HE, Lubarsky DA. How much are patients willing to pay to avoid postoperative nausea and vomiting? Anesth Analg. 2001;92:393-400.
Myles PS, Williams DL, Hendrata M, Anderson H, Weeks AM. Patient satisfaction after anaesthesia and surgery: results of a prospective survey of 10,811 patients. Br J Anaesth. 2000;84:6-10.
Dorman RB, Miller CJ, Leslie DB, et al. Risk for hospital readmission following bariatric surgery. Plos One. 2012;7:e32506.
Parra-Sanchez I, Abdallah R, You J, et al. A time-motion economic analysis of postoperative nausea and vomiting in ambulatory surgery. Canad J Anaesth. 2012;59:366-375.
Cook TM, Woodall N, Frerk C. Fourth National Audit P. Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 1: anaesthesia. Br J Anaesth. 2011;106:617-631.
Nicholson A, Lowe MC, Parker J, Lewis SR, Alderson P, Smith AF. Systematic review and meta-analysis of enhanced recovery programmes in surgical patients. Br J Surg. 2014;101:172-188.
Gan TJ, Meyer TA, Apfel CC, et al. Society for ambulatory anesthesia guidelines for the management of postoperative nausea and vomiting. Anesth Analg. 2007;105:1615-1628.table of contents.
Horn CC, Wallisch WJ, Homanics GE, Williams JP. Pathophysiological and neurochemical mechanisms of postoperative nausea and vomiting. Euro J Pharmacol. 2014;722:55-66.
Wiesmann T, Kranke P, Eberhart L. Postoperative nausea and vomiting-a narrative review of pathophysiology, pharmacotherapy and clinical management strategies. Expert Opin Pharmacother. 2015;16:1069-1077.
Diemunsch P, Joshi GP, Brichant JF. Neurokinin-1 receptor antagonists in the prevention of postoperative nausea and vomiting. Br J Anaesth. 2009;103:7-13.
Carlisle J, Stevenson CA. Drugs for preventing postoperative nausea and vomiting. Cochrane Database of Systematic Reviews. 2006;Issue 3. Art. No.: CD004125. https://doi.org/10.1002/14651858.CD004125.pub2 (accessed May 11/2021).
Tricco AC, Soobiah C, Blondal E, et al. Comparative efficacy of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med [Electr Resour]. 2015;13:136.
Tricco AC, Soobiah C, Blondal E, et al. Comparative safety of serotonin (5-HT3) receptor antagonists in patients undergoing surgery: a systematic review and network meta-analysis. BMC Med [Electr Resour]. 2015;13:142.
Malhotra A, Maughan D, Ansell J, et al. Choosing wisely in the UK: the Academy of Medical Royal Colleges' initiative to reduce the harms of too much medicine. BMJ (Clin Res Ed.). 2015;350:h2308.
Polderman JA, Farhang-Razi V, Van Dieren S, et al. Adverse side effects of dexamethasone in surgical patients. Cochr Datab System Rev (Online). 2018;11:CD011940.
Weibel S, Rücker G, Eberhart LH, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochr Datab System Rev (Online). 2020;10:CD012859.
Weibel S, Jelting Y, Pace N, et al. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: a network meta-analysis. Cochr Datab System Rev (Online). 2017;11:CD012859.
Tramer MR. The Fujii story: a chronicle of naive disbelief. Euro J Anaesthesiol. 2013;30:195-198.
Kranke P, Apfel CC, Roewer N, Fujii Y, et al. Reported data on granisetron and postoperative nausea and vomiting by Fujii et al. are incredibly nice! Anesth Analg. 2000;90:1004-1007.
Rücker G. Network meta-analysis, electrical networks and graph theory. Res Synth Methods. 2012;3:312-324.
Rücker G, Krahn U, König J, Efthimiou O, Schwarzer G. netmeta: network meta-analysis using frequentist methods. R package version 1.0-1. 2020. https://CRAN.R-project.org/package=netmeta
Rücker, G, Schwarzer, G. Reduce dimension or reduce weights? Comparing two approaches to multi-arm studies in network meta-analysis. Stat Med. 2014;33:4353-4369.
Sweeting, MJ, Sutton, AJ, Lambert, PC. What to add to nothing? Use and avoidance of continuity corrections in meta-analysis of sparse data. Stat Med. 2004;23:1351-1375.
Rücker, G, Schwarzer, G. Ranking treatments in frequentist network meta-analysis works without resampling methods. BMC Med Res Methodol [Electr Resour]. 2015;15:58.
Nikolakopoulou, A, Higgins, JPT, Papakonstantinou, T, Chaimani, A, Del Giovane, C, Egger, M, et al. CINeMA: An approach for assessing confidence in the results of a network meta-analysis. PLoS Med. 2020;17(4):e1003082. https://doi.org/10.1371/journal.pmed.1003082
Higgins, JP, Jackson, D, Barrett, JK, Lu, G, Ades, AE, White, IR. Consistency and inconsistency in network meta-analysis: concepts and models for multi-arm studies. Res Synth Methods. 2012;3:98-110.
Krahn, U, Binder, H, Konig, J. A graphical tool for locating inconsistency in network meta-analyses. BMC Med Res Methodol [Electr Resour]. 2013;13:35.
Chaimani, A, Caldwell, DM, Li, T, Higgins, JPT, Salanti, G. (2019). Chapter 11: undertaking network meta-analyses. In: Higgins JPT, Thomas J, Chandler J, et al., eds. Cochrane Handbook for Systematic Reviews of Interventions version 6.0 (updated July 2019). Cochrane, Available from www.training.cochrane.org/handbook
Salanti, G, Del Giovane, C, Chaimani, A, Caldwell, DM, Higgins, JP. Evaluating the quality of evidence from a network meta-analysis. Plos One 2014;9:e99682.
Papakonstantinou, T, Nikolakopoulou, A, Rucker, G, et al. Estimating the contribution of studies in network meta-analysis: paths, flows and streams. F1000Res. 2018;7:610.
Balshem, H, Helfand, M, Schunemann, HJ, et al. GRADE guidelines: 3. Rating the quality of evidence. J Clin Epidemiol. 2011;64:401-406.
Apfel, CC, Korttila, K, Abdalla, M, et al. A factorial trial of six interventions for the prevention of postoperative nausea and vomiting. N Engl J Med. 2004;350:2441-2451.
Puhan, MA, Schunemann, HJ, Murad, MH, et al. A GRADE Working Group approach for rating the quality of treatment effect estimates from network meta-analysis. BMJ (Clin Res Ed.). 2014;349:g5630.
Nikolakopoulou, A, Higgins, JPT, Papakonstantinou, T, et al. CINeMA: an approach for assessing confidence in the results of a network meta-analysis. Plos Med. 2020;17:e1003082.
Yepes-Nunez, JJ, Li, SA, Guyatt, G, et al. Development of the summary of findings table for network meta-analysis. J Clin Epidemiol. 2019;115:1-13.
Weibel S, Schaefer MS, Raj D, Rücker G, Pace NL, Schlesinger T, Meybohm P, Kienbaum P, Eberhart LHJ, Kranke P. Drugs for preventing postoperative nausea and vomiting in adults after general anaesthesia: an abridged Cochrane network meta-analysis. Anaesthesia. 2020 Nov 10. https://doi.org/10.1111/anae.15295. Epub ahead of print. PMID: 33170514.