Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin.

Acute Chest Syndrome Anemia, Sickle Cell Animals Chlorine Hemolysis Hemopexin Humans Mice
Chlorinated lipids Hemolysis Hypoxia Lung injury Red blood cells Sickling

Journal

Redox biology
ISSN: 2213-2317
Titre abrégé: Redox Biol
Pays: Netherlands
ID NLM: 101605639

Informations de publication

Date de publication:
08 2021
Historique:
received: 01 02 2021
revised: 30 04 2021
accepted: 11 05 2021
pubmed: 28 5 2021
medline: 6 7 2021
entrez: 27 5 2021
Statut: ppublish

Résumé

Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited. Chlorine (Cl

Identifiants

DOI: 10.1016/j.redox.2021.102009 PMID: 34044323 PMC: PMC8167148
pubmed: 34044323
pii: S2213-2317(21)00167-1
doi: 10.1016/j.redox.2021.102009
pmc: PMC8167148
pii:
doi:

Substances chimiques

Chlorine 4R7X1O2820
Hemopexin 9013-71-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

102009

Subventions

Organisme : NIEHS NIH HHS
ID : R21 ES032956
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES031559
Pays : United States
Organisme : NIEHS NIH HHS
ID : R21 ES034226
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES026458
Pays : United States
Organisme : NIEHS NIH HHS
ID : U01 ES027697
Pays : United States

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Ammar Saadoon Alishlash (AS)

Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, AL, USA. Electronic address: ammarsaadoon@uabmc.edu.

Muna Sapkota (M)

Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, AL, USA.

Israr Ahmad (I)

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

Kelsey Maclin (K)

Department of Environmental Health Sciences, School of Public Health, University of Alabama at Birmingham, AL, USA.

Noor A Ahmed (NA)

Department of Clinical and Diagnostic Sciences, School of Health Professions, University of Alabama at Birmingham, AL, USA.

Adam Molyvdas (A)

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

Stephen Doran (S)

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

Carolyn J Albert (CJ)

Saint Louis University Department of Biochemistry and Molecular Biology, USA.

Saurabh Aggarwal (S)

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

David A Ford (DA)

Saint Louis University Department of Biochemistry and Molecular Biology, USA.

Namasivayam Ambalavanan (N)

Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, AL, USA.

Tamas Jilling (T)

Department of Pediatrics, School of Medicine, University of Alabama at Birmingham, AL, USA; Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

Sadis Matalon (S)

Department of Anesthesiology and Perioperative Medicine, School of Medicine, University of Alabama at Birmingham, AL, USA.

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Classifications MeSH

questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Hémoglobinopathies › Drépanocytose › Syndrome thoracique aigu › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Hémoglobinopathies › Drépanocytose › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Eucaryotes › Animaux › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Chlore › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Phénomènes du système immunitaire › Réaction antigène-anticorps › Hémolyse › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Glycoprotéines › Hémopexine › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chlorine inhalation induces acute chest...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Chlorine inhalation induces acute chest...