Interest of a standardized hypnotic message for the reduction of pain and anxiety in cancer patients treated by capsaicin patch for neuropathic pain: a randomized controlled trial.
Administration, Topical
Adult
Aged
Analgesics
/ administration & dosage
Anxiety
/ prevention & control
Capsaicin
/ administration & dosage
Female
Humans
Hypnosis
/ methods
Male
Middle Aged
Music Therapy
Neoplasms
/ complications
Neuralgia
/ drug therapy
Pain, Procedural
/ prevention & control
Treatment Outcome
Anxiety
Cancer
Hypnosis
Music therapy
Pain
Journal
BMC complementary medicine and therapies
ISSN: 2662-7671
Titre abrégé: BMC Complement Med Ther
Pays: England
ID NLM: 101761232
Informations de publication
Date de publication:
27 May 2021
27 May 2021
Historique:
received:
14
01
2021
accepted:
17
05
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Neuropathic pain is characterized by spontaneous painful symptoms. Medical therapies include the use of a capsaicin 8% patch (Qutenza®, Grünenthal Gmbh, Germany), and patients may experience a sharp burning sensation at application and removal of the patch. This study aimed to evaluate the impact of playing a standardized hypnosis recording during application, on the pain and anxiety induced by capsaicin treatment. In a randomized, controlled trial, we assessed the benefits of the intervention firstly on pain and secondly on anxiety, as measured using numerical rating scales. All patients had application of the capsaicin patch, including the possibility for the patient to apply a cold patch. Participants were randomly assigned to one of 3 groups, namely the "Standard group" (no intervention), "Hypnosis group", in which a standardized hypnotic message was played during application, or the "Music group" in which relaxing music was played during application of the patch. Sixty-nine patients were included. Overall, there was no significant difference in pain scores between groups (p = 0.355). Compared to standard application, anxiety was significantly lower in the hypnosis group after application (p = 0.007), with no significant difference between the standard and music arms (p = 0.271), or between the hypnosis and music arms (p = 0.423). Listening to a standardized hypnotic message during application of a capsaicin patch was found to significantly lower anxiety. These findings indicate that the use of a hypnotic message can reduce discomfort and warrant its evaluation in other indications of pain or anxiety during treatment procedures. NCT02822625 .
Sections du résumé
BACKGROUND
BACKGROUND
Neuropathic pain is characterized by spontaneous painful symptoms. Medical therapies include the use of a capsaicin 8% patch (Qutenza®, Grünenthal Gmbh, Germany), and patients may experience a sharp burning sensation at application and removal of the patch. This study aimed to evaluate the impact of playing a standardized hypnosis recording during application, on the pain and anxiety induced by capsaicin treatment.
METHODS
METHODS
In a randomized, controlled trial, we assessed the benefits of the intervention firstly on pain and secondly on anxiety, as measured using numerical rating scales. All patients had application of the capsaicin patch, including the possibility for the patient to apply a cold patch. Participants were randomly assigned to one of 3 groups, namely the "Standard group" (no intervention), "Hypnosis group", in which a standardized hypnotic message was played during application, or the "Music group" in which relaxing music was played during application of the patch.
RESULTS
RESULTS
Sixty-nine patients were included. Overall, there was no significant difference in pain scores between groups (p = 0.355). Compared to standard application, anxiety was significantly lower in the hypnosis group after application (p = 0.007), with no significant difference between the standard and music arms (p = 0.271), or between the hypnosis and music arms (p = 0.423).
CONCLUSIONS
CONCLUSIONS
Listening to a standardized hypnotic message during application of a capsaicin patch was found to significantly lower anxiety. These findings indicate that the use of a hypnotic message can reduce discomfort and warrant its evaluation in other indications of pain or anxiety during treatment procedures.
TRIAL REGISTRATION
BACKGROUND
NCT02822625 .
Identifiants
pubmed: 34044838
doi: 10.1186/s12906-021-03329-8
pii: 10.1186/s12906-021-03329-8
pmc: PMC8161949
doi:
Substances chimiques
Analgesics
0
Capsaicin
S07O44R1ZM
Banques de données
ClinicalTrials.gov
['NCT02822625']
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
154Références
J Pain. 2010 Jun;11(6):579-87
pubmed: 20400377
Int J Clin Exp Hypn. 1979 Jan;27(1):29-41
pubmed: 541126
Expert Rev Neurother. 2011 Jan;11(1):15-27
pubmed: 21158551
Neurosci Biobehav Rev. 2019 Apr;99:298-310
pubmed: 30790634
Curr Med Res Opin. 2012 Jun;28(6):937-51
pubmed: 22551228
Burns. 2018 Feb;44(1):108-117
pubmed: 28801149
Br J Anaesth. 2011 Oct;107(4):490-502
pubmed: 21852280
Brain Res Cogn Brain Res. 2003 Jul;17(2):255-62
pubmed: 12880897
Int J Clin Exp Hypn. 2016;64(1):75-115
pubmed: 26599994
Drugs. 2018 Sep;78(14):1489-1500
pubmed: 30251173
Lancet. 2015 Oct 24;386(10004):1659-71
pubmed: 26277246
Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl 11:S240-52
pubmed: 22588748
Drug Des Devel Ther. 2017 Sep 13;11:2709-2718
pubmed: 29066862
Lancet Neurol. 2008 Dec;7(12):1106-12
pubmed: 18977178
Pain. 2007 Jul;130(1-2):137-43
pubmed: 17215080
Conscious Cogn. 2005 Jun;14(2):304-15
pubmed: 15950884
J Clin Epidemiol. 2007 Apr;60(4):356-60
pubmed: 17346609
Int J Clin Exp Hypn. 1978 Oct;26(4):307-16
pubmed: 681032