Strategies to load therapeutics into polysaccharide-based nanogels with a focus on microfluidics: A review.

Adjuvants, Immunologic / chemistry Animals Carbohydrate Sequence Drug Carriers / chemistry Drug Compounding / methods Gene Transfer Techniques Humans Hydrophobic and Hydrophilic Interactions Immunity / drug effects Microfluidics / methods Nanogels / chemistry Polysaccharides / chemistry Static Electricity Vaccines, Synthetic / chemistry
Drug loading methods Microfluidics Nanogels Nanogels-based vaccines Polysaccharides

Journal

Carbohydrate polymers
ISSN: 1879-1344
Titre abrégé: Carbohydr Polym
Pays: England
ID NLM: 8307156

Informations de publication

Date de publication:
15 Aug 2021
Historique:
received: 11 02 2021
revised: 04 04 2021
accepted: 15 04 2021
entrez: 28 5 2021
pubmed: 29 5 2021
medline: 16 10 2021
Statut: ppublish

Résumé

Nowadays nanoparticles are increasingly investigated for the targeted and controlled delivery of therapeutics, as suggested by the high number of research articles (2400 in 2000 vs 8500 in 2020). Among them, almost 2% investigated nanogels in 2020. Nanogels or nanohydrogels (NGs) are nanoparticles formed by a swollen three-dimensional network of synthetic polymers or natural macromolecules such as polysaccharides. NGs represent a highly versatile nanocarrier, able to deliver a number of therapeutics. Currently, NGs are undergoing clinical trials for the delivery of anti-cancer vaccines. Herein, the strategies to load low molecular weight drugs, (poly)peptides and genetic material into polysaccharide NGs as well as to formulate NGs-based vaccines are summarized, with a focus on the microfluidics approach.

Identifiants

DOI: 10.1016/j.carbpol.2021.118119 PMID: 34044935
pubmed: 34044935
pii: S0144-8617(21)00506-3
doi: 10.1016/j.carbpol.2021.118119
pii:
doi:

Substances chimiques

Adjuvants, Immunologic 0
Drug Carriers 0
Nanogels 0
Polysaccharides 0
Vaccines, Synthetic 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

118119

Informations de copyright

Copyright © 2021. Published by Elsevier Ltd.

Auteurs

N Zoratto (N)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: nicole.zoratto@uniroma1.it.

E Montanari (E)

Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093 Zurich, Switzerland. Electronic address: elita.montanari@pharma.ethz.ch.

M Viola (M)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: viola.1943830@studenti.uniroma1.it.

J Wang (J)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: ju.wang@uniroma1.it.

T Coviello (T)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: tommasina.coviello@uniroma1.it.

C Di Meo (C)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: chiara.dimeo@uniroma1.it.

P Matricardi (P)

Department of Drug Chemistry and Technologies, Sapienza University of Rome, 00185 Roma, Italy. Electronic address: pietro.matricardi@uniroma1.it.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Strategies to load therapeutics into...
questionsmedicales.fr › Eucaryotes › Animaux › Strategies to load therapeutics into...
questionsmedicales.fr › Sciences de l'information › Sources d'information › Services d'information › Documentation › Données de séquences moléculaires › Séquence glucidique › Strategies to load therapeutics into...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Vecteurs de médicaments › Strategies to load therapeutics into...
questionsmedicales.fr › Techniques d'investigation › Préparation de médicament › Strategies to load therapeutics into...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de transfert de gènes › Strategies to load therapeutics into...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Strategies to load therapeutics into...
questionsmedicales.fr › Phénomènes chimiques › Interactions hydrophobes et hydrophiles › Strategies to load therapeutics into...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Strategies to load therapeutics into...
questionsmedicales.fr › Technologie, industrie et agriculture › Technologie › Miniaturisation › Microtechnologie › Microfluidique › Strategies to load therapeutics into...
questionsmedicales.fr › Technologie, industrie et agriculture › Produits manufacturés › Nanostructures › Nanoparticules › Nanogels › Strategies to load therapeutics into...
questionsmedicales.fr › Glucides › Polyosides › Strategies to load therapeutics into...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électricité › Électricité statique › Strategies to load therapeutics into...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Vaccins synthétiques › Strategies to load therapeutics into...