3D genomics across the tree of life reveals condensin II as a determinant of architecture type.
Adenosine Triphosphatases
/ chemistry
Algorithms
Animals
Biological Evolution
Cell Nucleolus
/ ultrastructure
Cell Nucleus
/ ultrastructure
Centromere
/ ultrastructure
Chromosomes
/ chemistry
Chromosomes, Human
/ chemistry
DNA-Binding Proteins
/ chemistry
Eukaryota
/ genetics
Genome
Genome, Human
Genomics
Heterochromatin
/ ultrastructure
Humans
Interphase
Mitosis
Models, Biological
Multiprotein Complexes
/ chemistry
Telomere
/ ultrastructure
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
28 05 2021
28 05 2021
Historique:
received:
19
08
2020
accepted:
16
04
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
12
6
2021
Statut:
ppublish
Résumé
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional (3D) genome architectures at the chromosome scale. Each type appears and disappears repeatedly during eukaryotic evolution. The type of genome architecture that an organism exhibits correlates with the absence of condensin II subunits. Moreover, condensin II depletion converts the architecture of the human genome to a state resembling that seen in organisms such as fungi or mosquitoes. In this state, centromeres cluster together at nucleoli, and heterochromatin domains merge. We propose a physical model in which lengthwise compaction of chromosomes by condensin II during mitosis determines chromosome-scale genome architecture, with effects that are retained during the subsequent interphase. This mechanism likely has been conserved since the last common ancestor of all eukaryotes.
Identifiants
pubmed: 34045355
pii: 372/6545/984
doi: 10.1126/science.abe2218
pmc: PMC8172041
mid: NIHMS1704706
doi:
Substances chimiques
DNA-Binding Proteins
0
Heterochromatin
0
Multiprotein Complexes
0
condensin complexes
0
Adenosine Triphosphatases
EC 3.6.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
984-989Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK121366
Pays : United States
Organisme : NHGRI NIH HHS
ID : UM1 HG009375
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022537
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS114491
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG062257
Pays : United States
Organisme : NIDDK NIH HHS
ID : U54 DK107965
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045183
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP1 DK113644
Pays : United States
Organisme : NCCIH NIH HHS
ID : R01 AT009050
Pays : United States
Organisme : NICHD NIH HHS
ID : P41 HD071837
Pays : United States
Organisme : NHGRI NIH HHS
ID : DP2 HG010013
Pays : United States
Informations de copyright
Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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