Effect of Day 3 and Day 5/6 Embryo Quality on the Reproductive Outcomes in the Single Vitrified Embryo Transfer Cycles.
Adult
Birth Rate
Blastocyst
Cryopreservation
/ methods
Embryo Culture Techniques
/ methods
Embryo Transfer
/ methods
Female
Fertilization in Vitro
/ methods
Humans
Live Birth
Pregnancy
Pregnancy Rate
Retrospective Studies
Single Embryo Transfer
/ methods
Sperm Injections, Intracytoplasmic
/ methods
Treatment Outcome
Vitrification
birth weight
blastocyst transfer
embryo quality
live birth
vitrification
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
12
2020
accepted:
06
04
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
15
1
2022
Statut:
epublish
Résumé
To explore the live birth rate and neonatal outcome after single vitrified blastocyst transfer versus single vitrified cleavage-stage embryo transfer at different grades of embryo quality. A retrospective cohort study including 6077 single vitrified-thawed embryo transfer cycles was performed in the time-period from January 2013 to December 2018. After controlling for potential confounding variables, there are 161% increased odds of a live birth after transfer of single good quality embryo at day 5, 152% increased odds of a live birth after transfer of single poor quality embryo at day 5, 60% increased odds of a live birth after transfer of single good quality embryo at day 6 compared with transfer of single good quality embryo at day 3. Results from the generalized estimated equation regression showed significant relationship of unadjusted birth weight with development stage of embryo and embryo quality (good quality embryo on day 5 vs. Good quality embryo on day 3:β=108.55, SE=34.89, P=0.002; good quality embryo on day 6 vs. Good quality embryo on day 3:β=68.80, SE=33.75, P=0.041). However, no significant differences were seen in birth weight between transfer single poor quality embryo on day 5, 6 and transfer single good quality embryo on day 3. A significant increase in live birth rate and birth weight after transfer of single good quality embryo on day 5 and day 6 compared with transfer of single good quality embryo on day 3 in the vitrified embryo transfer cycles.
Identifiants
pubmed: 34046010
doi: 10.3389/fendo.2021.641623
pmc: PMC8147686
doi:
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
641623Informations de copyright
Copyright © 2021 Wang, Zhao, Ma, Zhu and Wang.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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