Myeloid Arginase 1 Insufficiency Exacerbates Amyloid-β Associated Neurodegenerative Pathways and Glial Signatures in a Mouse Model of Alzheimer's Disease: A Targeted Transcriptome Analysis.
Alzheimer Disease
/ enzymology
Amyloid beta-Peptides
/ metabolism
Amyloid beta-Protein Precursor
/ genetics
Animals
Arginase
/ genetics
Brain
/ enzymology
Disease Models, Animal
Female
Gene Expression Profiling
Gene Regulatory Networks
Haploinsufficiency
Humans
Male
Mice, Inbred C57BL
Mice, Transgenic
Microglia
/ enzymology
Mutation
Myeloid Cells
/ enzymology
Nerve Degeneration
Transcriptome
APP Tg2576
amyloidosis
arginine metabolism
infiltrating macrophage
microglia
nCounter technology
neurodegeneration
neuroinflammation
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
11
11
2020
accepted:
12
04
2021
entrez:
28
5
2021
pubmed:
29
5
2021
medline:
16
9
2021
Statut:
epublish
Résumé
Brain myeloid cells, include infiltrating macrophages and resident microglia, play an essential role in responding to and inducing neurodegenerative diseases, such as Alzheimer's disease (AD). Genome-wide association studies (GWAS) implicate many AD casual and risk genes enriched in brain myeloid cells. Coordinated arginine metabolism through arginase 1 (
Identifiants
pubmed: 34046031
doi: 10.3389/fimmu.2021.628156
pmc: PMC8144303
doi:
Substances chimiques
APP protein, human
0
Amyloid beta-Peptides
0
Amyloid beta-Protein Precursor
0
Arg1 protein, mouse
EC 3.5.3.1
Arginase
EC 3.5.3.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
628156Subventions
Organisme : NIA NIH HHS
ID : R01 AG051500
Pays : United States
Organisme : NINDS NIH HHS
ID : F31 NS110264
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI095307
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091582
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054559
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055996
Pays : United States
Informations de copyright
Copyright © 2021 Ma, Hunt, Kovalenko, Liang, Selenica, Orr, Zhang, Gensel, Feola, Gordon, Morgan, Bickford and Lee.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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