Self-reported alcohol consumption, carbohydrate deficient transferrin and risk of cardiovascular disease: The PREVEND prospective cohort study.

Alcohol Drinking Alcoholism Biomarkers Carbohydrates Cardiovascular Diseases / epidemiology Female Humans Male Middle Aged Prospective Studies Self Report Transferrin / analysis
Alcohol consumption Carbohydrate-deficient transferrin Cardiovascular disease Risk factor

Journal

Clinica chimica acta; international journal of clinical chemistry
ISSN: 1873-3492
Titre abrégé: Clin Chim Acta
Pays: Netherlands
ID NLM: 1302422

Informations de publication

Date de publication:
Sep 2021
Historique:
received: 20 01 2021
revised: 24 05 2021
accepted: 24 05 2021
pubmed: 29 5 2021
medline: 21 7 2021
entrez: 28 5 2021
Statut: ppublish

Résumé

Self-reported alcohol consumption is an established risk factor for cardiovascular disease (CVD). Carbohydrate deficient transferrin (CDT) is an established objective marker of excessive alcohol consumption, but data on its prospective association with CVD are lacking. We aimed to evaluate the associations of self-reported alcohol consumption and CDT (expressed as %CDT, a more reliable marker than absolute CDT levels) with CVD risk. In the PREVEND prospective study of 5,206 participants (mean age, 53 years; 47.7% males), alcohol consumption by self-reports, absolute CDT measured using the Siemens nephelometric assay and %CDT calculated as the percentage of total transferrin concentrations, were assessed at baseline. Alcohol consumption was classified into 5 categories: abstention (reference), light, light-moderate, moderate and heavy alcohol consumption.Hazard ratios (HRs) (95% confidence intervals [CI]) for first CVD events were estimated. Mean (SD) of %CDT was 1.59 (0.54) %. During a median follow-up of 8.3 years, 326 first CVD events were recorded. Compared with abstainers, the multivariable-adjusted HRs (95% CIs) of CVD for light, light-moderate, moderate and heavy alcohol consumption were 0.66 (0.46-0.95), 0.83 (0.62-1.11), 0.83 (0.61-1.14) and 0.80 (0.48-1.36), respectively. Light alcohol consumption was associated with reduced coronary heart disease risk 0.62 (0.40-0.96), whereas light-moderate alcohol consumption was associated with reduced stroke risk 0.45 (0.24-0.83). The association of %CDT with CVD risk was not significant. Our findings confirm the established association between self-reported light to moderate alcohol consumption and reduced CVD risk. However, %CDT within the normal reference range may not be a risk indicator for CVD.

Sections du résumé

BACKGROUND BACKGROUND
Self-reported alcohol consumption is an established risk factor for cardiovascular disease (CVD). Carbohydrate deficient transferrin (CDT) is an established objective marker of excessive alcohol consumption, but data on its prospective association with CVD are lacking. We aimed to evaluate the associations of self-reported alcohol consumption and CDT (expressed as %CDT, a more reliable marker than absolute CDT levels) with CVD risk.
MATERIALS AND METHODS METHODS
In the PREVEND prospective study of 5,206 participants (mean age, 53 years; 47.7% males), alcohol consumption by self-reports, absolute CDT measured using the Siemens nephelometric assay and %CDT calculated as the percentage of total transferrin concentrations, were assessed at baseline. Alcohol consumption was classified into 5 categories: abstention (reference), light, light-moderate, moderate and heavy alcohol consumption.Hazard ratios (HRs) (95% confidence intervals [CI]) for first CVD events were estimated.
RESULTS RESULTS
Mean (SD) of %CDT was 1.59 (0.54) %. During a median follow-up of 8.3 years, 326 first CVD events were recorded. Compared with abstainers, the multivariable-adjusted HRs (95% CIs) of CVD for light, light-moderate, moderate and heavy alcohol consumption were 0.66 (0.46-0.95), 0.83 (0.62-1.11), 0.83 (0.61-1.14) and 0.80 (0.48-1.36), respectively. Light alcohol consumption was associated with reduced coronary heart disease risk 0.62 (0.40-0.96), whereas light-moderate alcohol consumption was associated with reduced stroke risk 0.45 (0.24-0.83). The association of %CDT with CVD risk was not significant.
CONCLUSIONS CONCLUSIONS
Our findings confirm the established association between self-reported light to moderate alcohol consumption and reduced CVD risk. However, %CDT within the normal reference range may not be a risk indicator for CVD.

Identifiants

DOI: 10.1016/j.cca.2021.05.024 PMID: 34048731
pubmed: 34048731
pii: S0009-8981(21)00180-7
doi: 10.1016/j.cca.2021.05.024
pii:
doi:

Substances chimiques

Biomarkers 0
Carbohydrates 0
Transferrin 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-7

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Setor K Kunutsor (SK)

National Institute for Health Research Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, UK; Musculoskeletal Research Unit, Translational Health Sciences, Bristol Medical School, University of Bristol, Learning & Research Building (Level 1), Southmead Hospital, Bristol BS10 5NB, UK. Electronic address: skk31@cantab.net.

Daan Kremer (D)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Michele F Eisenga (MF)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Eke G Gruppen (EG)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Martin H de Borst (MH)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Anneke C Muller Kobold (AC)

Department of Laboratory Medicine, University of Groningen and University Medical Center, Groningen, the Netherlands.

Jenny E Kootstra-Ros (JE)

Department of Laboratory Medicine, University of Groningen and University Medical Center, Groningen, the Netherlands.

Robin P F Dullaart (RPF)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

Stephan J L Bakker (SJL)

Department of Internal Medicine, University of Groningen and University Medical Center Groningen, Groningen, the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement dipsique › Consommation d'alcool › Self-reported alcohol consumption,...
questionsmedicales.fr › Troubles mentaux › Troubles liés à une substance › Troubles liés à l'alcool › Alcoolisme › Self-reported alcohol consumption,...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Self-reported alcohol consumption,...
questionsmedicales.fr › Glucides › Self-reported alcohol consumption,...
questionsmedicales.fr › Maladies cardiovasculaires › Self-reported alcohol consumption,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Self-reported alcohol consumption,...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Self-reported alcohol consumption,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Self-reported alcohol consumption,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Autorapport › Self-reported alcohol consumption,...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Métalloprotéines › Protéines de liaison au fer › Transferrines › Transferrine › Self-reported alcohol consumption,...