Assessment of cognitive and psychomotor impairment, subjective effects, and blood THC concentrations following acute administration of oral and vaporized cannabis.
Cannabis
cannabis edibles
cannabis vaporizers
impairment
Journal
Journal of psychopharmacology (Oxford, England)
ISSN: 1461-7285
Titre abrégé: J Psychopharmacol
Pays: United States
ID NLM: 8907828
Informations de publication
Date de publication:
Jul 2021
Jul 2021
Historique:
pubmed:
30
5
2021
medline:
27
1
2022
entrez:
29
5
2021
Statut:
ppublish
Résumé
Cannabis legalization is expanding, but there are no established methods for detecting cannabis impairment. Characterize the acute impairing effects of oral and vaporized cannabis using various performance tests. Participants ( Low oral/vaporized doses did not impair cognitive/psychomotor performance relative to placebo but produced positive subjective effects. High oral/vaporized doses impaired cognitive/psychomotor performance and increased positive and negative subjective effects. The DRUID Standard approaches for identifying impairment due to cannabis exposure (i.e. blood THC and field sobriety tests) have severe limitations. There is a need to identify novel biomarkers of cannabis exposure and/or behavioral tests like the DRUID
Sections du résumé
BACKGROUND
BACKGROUND
Cannabis legalization is expanding, but there are no established methods for detecting cannabis impairment.
AIM
OBJECTIVE
Characterize the acute impairing effects of oral and vaporized cannabis using various performance tests.
METHODS
METHODS
Participants (
RESULTS
RESULTS
Low oral/vaporized doses did not impair cognitive/psychomotor performance relative to placebo but produced positive subjective effects. High oral/vaporized doses impaired cognitive/psychomotor performance and increased positive and negative subjective effects. The DRUID
CONCLUSIONS
CONCLUSIONS
Standard approaches for identifying impairment due to cannabis exposure (i.e. blood THC and field sobriety tests) have severe limitations. There is a need to identify novel biomarkers of cannabis exposure and/or behavioral tests like the DRUID
Identifiants
pubmed: 34049452
doi: 10.1177/02698811211021583
pmc: PMC9361180
mid: NIHMS1826605
doi:
Substances chimiques
Cannabinoid Receptor Agonists
0
Dronabinol
7J8897W37S
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
786-803Subventions
Organisme : NIDA NIH HHS
ID : R44 DA046272
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007209
Pays : United States
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