Contribution of astrocytes to neurovascular coupling in the spinal cord of the rat.
Astrocyte
Blood flow
Fluorocitrate
Local field potential
Neurovascular coupling
Spinal cord
Journal
The journal of physiological sciences : JPS
ISSN: 1880-6562
Titre abrégé: J Physiol Sci
Pays: Japan
ID NLM: 101262417
Informations de publication
Date de publication:
28 May 2021
28 May 2021
Historique:
received:
15
02
2021
accepted:
19
05
2021
entrez:
29
5
2021
pubmed:
30
5
2021
medline:
25
12
2021
Statut:
epublish
Résumé
Functional magnetic resonance imaging (fMRI) of the spinal cord relies on the integrity of neurovascular coupling (NVC) to infer neuronal activity from hemodynamic changes. Astrocytes are a key component of cerebral NVC, but their role in spinal NVC is unclear. The objective of this study was to examine whether inhibition of astrocyte metabolism by fluorocitrate alters spinal NVC. In 14 rats, local field potential (LFP) and spinal cord blood flow (SCBF) were recorded simultaneously in the lumbosacral enlargement during noxious stimulation of the sciatic nerve before and after a local administration of fluorocitrate (N = 7) or saline (N = 7). Fluorocitrate significantly reduced SCBF responses (p < 0.001) but not LFP amplitude (p = 0.22) compared with saline. Accordingly, NVC was altered by fluorocitrate compared with saline (p < 0.01). These results support the role of astrocytes in spinal NVC and have implications for spinal cord imaging with fMRI for conditions in which astrocyte metabolism may be altered.
Identifiants
pubmed: 34049480
doi: 10.1186/s12576-021-00800-6
pii: 10.1186/s12576-021-00800-6
pmc: PMC10717833
doi:
Substances chimiques
Citrates
0
fluorocitrate
357-89-1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
16Subventions
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 05403
Références
Curr Opin Neurobiol. 2019 Oct;58:61-69
pubmed: 31336326
News Physiol Sci. 2002 Feb;17:27-31
pubmed: 11821533
J Neurosci. 2015 Mar 11;35(10):4248-57
pubmed: 25762671
Neuroscience. 2017 Feb 20;343:250-259
pubmed: 27998779
J Neurosci. 2015 May 27;35(21):8245-57
pubmed: 26019339
Acta Physiol (Oxf). 2014 Apr;210(4):790-8
pubmed: 24629161
Trends Neurosci. 2009 Mar;32(3):160-9
pubmed: 19162338
Adv Enzymol Relat Subj Biochem. 1957;18:113-59
pubmed: 13444108
Nature. 2001 Jul 12;412(6843):150-7
pubmed: 11449264
PLoS One. 2020 May 21;15(5):e0228759
pubmed: 32437449
Vet Hum Toxicol. 1990 Oct;32(5):427-31
pubmed: 2238438
Pain. 2013 Aug;154(8):1434-41
pubmed: 23707276
J Neurochem. 1987 May;48(5):1377-85
pubmed: 3559554
Cold Spring Harb Perspect Biol. 2015 Apr 15;7(6):
pubmed: 25877220
Anat Rec (Hoboken). 2018 Sep;301(9):1585-1595
pubmed: 29752872
Neuroimage. 2021 Jan 1;224:117439
pubmed: 33039624
Brain Sci. 2018 Sep 10;8(9):
pubmed: 30201938
Brain Res. 1992 Mar 27;576(1):120-4
pubmed: 1515906
J Neurosci. 1996 Feb 1;16(3):1219-29
pubmed: 8558250
Science. 2008 Jun 20;320(5883):1638-43
pubmed: 18566287
Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1647-E1656
pubmed: 29382752
Glia. 1997 Sep;21(1):106-13
pubmed: 9298853
Nature. 2006 Oct 12;443(7112):700-4
pubmed: 17036005
Nature. 2010 Nov 11;468(7321):232-43
pubmed: 21068832
Nat Neurosci. 2006 Feb;9(2):260-7
pubmed: 16388306
Cereb Cortex. 2008 Dec;18(12):2789-95
pubmed: 18372288
Neuron. 2018 Dec 5;100(5):1133-1148.e3
pubmed: 30482689
J Neurosci. 2015 Mar 11;35(10):4168-78
pubmed: 25762664
J Neurosci Res. 2007 Nov 15;85(15):3347-58
pubmed: 17847118
Neuroimage. 2014 Jan 1;84:1082-93
pubmed: 23859923
Cell Rep. 2018 Jun 26;23(13):3878-3890
pubmed: 29949771
J Neurosci. 2003 Feb 1;23(3):1026-40
pubmed: 12574433
Eur J Neurosci. 2009 Jul;30(2):242-50
pubmed: 19659924
Nat Neurosci. 2016 May 26;19(6):771-83
pubmed: 27227366
Brain Res. 1990 Oct 22;530(2):295-300
pubmed: 2176116
J Comp Neurol. 1992 Jul 8;321(2):209-22
pubmed: 1380014
Nat Neurosci. 2003 Jan;6(1):43-50
pubmed: 12469126
Stroke. 1997 May;28(5):1066-72
pubmed: 9158651
Nat Neurosci. 2020 Nov;23(11):1376-1387
pubmed: 33020652
J Physiol Sci. 2019 Jan;69(1):13-21
pubmed: 29600499
Neurosci Res. 2000 Mar;36(3):215-26
pubmed: 10683525
Trends Neurosci. 2018 Jul;41(7):409-413
pubmed: 29933772
Neuroscience. 2017 Jul 4;355:1-8
pubmed: 28479402
Eur J Neurosci. 2004 May;19(9):2446-54
pubmed: 15128398
Front Physiol. 2020 Dec 10;11:611884
pubmed: 33362585
J Neurosci Res. 2003 Oct 1;74(1):160-6
pubmed: 13130518
Nat Neurosci. 2017 May;20(5):717-726
pubmed: 28319610
Acta Physiol (Oxf). 2011 Sep;203(1):47-59
pubmed: 21272266
Glia. 2020 Sep;68(9):1692-1728
pubmed: 31958188
Glia. 2018 Sep;66(9):2013-2023
pubmed: 29845643
J Neurosci. 2006 Mar 15;26(11):2862-70
pubmed: 16540563