Prevotella diversity, niches and interactions with the human host.
Journal
Nature reviews. Microbiology
ISSN: 1740-1534
Titre abrégé: Nat Rev Microbiol
Pays: England
ID NLM: 101190261
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
accepted:
09
04
2021
pubmed:
30
5
2021
medline:
24
9
2021
entrez:
29
5
2021
Statut:
ppublish
Résumé
The genus Prevotella includes more than 50 characterized species that occur in varied natural habitats, although most Prevotella spp. are associated with humans. In the human microbiome, Prevotella spp. are highly abundant in various body sites, where they are key players in the balance between health and disease. Host factors related to diet, lifestyle and geography are fundamental in affecting the diversity and prevalence of Prevotella species and strains in the human microbiome. These factors, along with the ecological relationship of Prevotella with other members of the microbiome, likely determine the extent of the contribution of Prevotella to human metabolism and health. Here we review the diversity, prevalence and potential connection of Prevotella spp. in the human host, highlighting how genomic methods and analysis have improved and should further help in framing their ecological role. We also provide suggestions for future research to improve understanding of the possible functions of Prevotella spp. and the effects of the Western lifestyle and diet on the host-Prevotella symbiotic relationship in the context of maintaining human health.
Identifiants
pubmed: 34050328
doi: 10.1038/s41579-021-00559-y
pii: 10.1038/s41579-021-00559-y
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
585-599Subventions
Organisme : NCI NIH HHS
ID : U01 CA230551
Pays : United States
Informations de copyright
© 2021. Springer Nature Limited.
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