3D-Printed Hydrogel-Filled Microneedle Arrays.


Journal

Advanced healthcare materials
ISSN: 2192-2659
Titre abrégé: Adv Healthc Mater
Pays: Germany
ID NLM: 101581613

Informations de publication

Date de publication:
07 2021
Historique:
revised: 09 04 2021
received: 02 11 2020
pubmed: 30 5 2021
medline: 6 8 2021
entrez: 29 5 2021
Statut: ppublish

Résumé

Microneedle arrays (MNAs) have been used for decades to deliver drugs transdermally and avoid the obstacles of other delivery routes. Hydrogels are another popular method for delivering therapeutics because they provide tunable, controlled release of their encapsulated payload. However, hydrogels are not strong or stiff, and cannot be formed into constructs that penetrate the skin. Accordingly, it has so far been impossible to combine the transdermal delivery route provided by MNAs with the therapeutic encapsulation potential of hydrogels. To address this challenge, a low cost and simple, but robust, strategy employing MNAs is developed. These MNAs are formed from a rigid outer layer, 3D printed onto a conformal backing, and filled with drug-eluting hydrogels. Microneedles of different lengths are fabricated on a single patch, facilitating the delivery of various agents to different tissue depths. In addition to spatial distribution, temporal release kinetics can be controlled by changing the hydrogel composition or the needles' geometry. As a proof-of-concept, MNAs are used for the delivery of vascular endothelial growth factor (VEGF). Application of the rigid, resin-based outer layer allows the use of hydrogels regardless of their mechanical properties and makes these multicomponent MNAs suitable for a range of drug delivery applications.

Identifiants

pubmed: 34050600
doi: 10.1002/adhm.202001922
doi:

Substances chimiques

Hydrogels 0
Vascular Endothelial Growth Factor A 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2001922

Subventions

Organisme : NIAMS NIH HHS
ID : R01 AR073822
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM126831
Pays : United States
Organisme : NIH HHS
ID : AR073822
Pays : United States
Organisme : NIH HHS
ID : GM126831
Pays : United States

Informations de copyright

© 2021 Wiley-VCH GmbH.

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Auteurs

Lindsay Barnum (L)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Jacob Quint (J)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Hossein Derakhshandeh (H)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.

Mohamadmahdi Samandari (M)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.

Fariba Aghabaglou (F)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.

Ali Farzin (A)

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.

Laleh Abbasi (L)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.

Sidi Bencherif (S)

Department of Chemical Engineering, Department of Bioengineering, Northeastern University, Boston, MA, 02115, USA.
John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02128, USA.

Adnan Memic (A)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Center of Nanotechnology, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.

Pooria Mostafalu (P)

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02139, USA.

Ali Tamayol (A)

Department of Mechanical and Materials Engineering, University of Nebraska, Lincoln, NE, 68588, USA.
Department of Biomedical Engineering, University of Connecticut Health Center, Farmington, CT, 06030, USA.

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