A novel self-assembled epitope peptide nanoemulsion vaccine targeting nasal mucosal epithelial cell for reinvigorating CD8


Journal

International journal of biological macromolecules
ISSN: 1879-0003
Titre abrégé: Int J Biol Macromol
Pays: Netherlands
ID NLM: 7909578

Informations de publication

Date de publication:
31 Jul 2021
Historique:
received: 26 03 2021
revised: 13 05 2021
accepted: 23 05 2021
pubmed: 31 5 2021
medline: 29 7 2021
entrez: 30 5 2021
Statut: ppublish

Résumé

Epitope peptides are not suitable for nasal administration immunity due to their poor immunogenicity and low delivery efficiency. Here, we reported an intranasal self-assembled nanovaccine (I-OVA NE), which was loaded with the peptides IKVAV-OVA

Identifiants

pubmed: 34052270
pii: S0141-8130(21)01133-8
doi: 10.1016/j.ijbiomac.2021.05.158
pii:
doi:

Substances chimiques

Cancer Vaccines 0
Emulsions 0
Laminin 0
Peptide Fragments 0
isoleucyl-lysyl-valyl-alanyl-valine 131167-89-0
Ovalbumin 9006-59-1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1891-1902

Informations de copyright

Copyright © 2021 Elsevier B.V. All rights reserved.

Auteurs

Yun Yang (Y)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Shuang Ge (S)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Zhen Song (Z)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Anni Zhao (A)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Liqun Zhao (L)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Zhiming Hu (Z)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Dingyi Cai (D)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Zelong Zhang (Z)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Liusheng Peng (L)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Dongshui Lu (D)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Ping Luo (P)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Weijun Zhang (W)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China.

Hongwu Sun (H)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China. Electronic address: sunhongwu2001@163.com.

Quanming Zou (Q)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China. Electronic address: qmzou2007@163.com.

Hao Zeng (H)

National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China. Electronic address: zeng1109@163.com.

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Classifications MeSH