Spilanthes acmella Murr. ameliorates chronic stress through improving mitochondrial function in chronic restraint stress rats.
Animals
Antioxidants
Asteraceae
/ chemistry
Behavior, Animal
/ drug effects
Chaperonin 60
/ biosynthesis
Chronic Disease
Cognition
/ drug effects
Depression
/ drug therapy
Hippocampus
/ drug effects
Male
Mitochondria
/ drug effects
Mitochondrial Dynamics
/ drug effects
Mitochondrial Proteins
/ biosynthesis
Plant Extracts
/ therapeutic use
Plants, Medicinal
Rats
Rats, Sprague-Dawley
Restraint, Physical
Stress, Psychological
/ drug therapy
Chronic stress
Depression
Mitochondrial dynamics
Spilanthes acmella Murr.
Journal
Neurochemistry international
ISSN: 1872-9754
Titre abrégé: Neurochem Int
Pays: England
ID NLM: 8006959
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
30
12
2020
revised:
20
05
2021
accepted:
23
05
2021
pubmed:
31
5
2021
medline:
27
1
2022
entrez:
30
5
2021
Statut:
ppublish
Résumé
Chronic stress is a risk factor for the development of psychiatric illnesses through impairment of the ability to appropriately regulate physiological and behavioral responses, but the molecular events that lead to damage of hippocampal neurons remain unclear. The medicinal herb Spilanthes acmella Murr. has been used as a traditional medicine for various diseases and its extracts exhibit antioxidant activity. The present study explored the molecular signals of mitochondrial dynamics and investigated the beneficial effects of S. acmella Murr. An ethyl acetate extract of this plant was used to assess mitochondrial dynamics in response to chronic restraint stress (CRS) in male Sprague-Dawley rats. The results demonstrated that the S. acmella Murr. extract reduced the expression of mitochondrial fission protein but induced HSP60, MnSOD and ATPsynthase in the hippocampus of the CRS rats. In addition, S. acmella Murr. extract reversed depressive symptoms in the forced swim test. Our findings suggested that S. acmella Murr. extract provides a potential treatment of chronic stress, and that the mechanism is associated with the alleviation of neuronal injury and maintenance of mitochondrial function.
Identifiants
pubmed: 34052298
pii: S0197-0186(21)00129-7
doi: 10.1016/j.neuint.2021.105083
pii:
doi:
Substances chimiques
Antioxidants
0
Chaperonin 60
0
Hspd1 protein, rat
0
Mitochondrial Proteins
0
Plant Extracts
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
105083Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.