Impact of ibuprofen and peroxisome proliferator-activated receptor gamma on emotion-related neural activation: A randomized, placebo-controlled trial.
Depression
Emotional faces
Ibuprofen
NSAIDs
PPAR gamma
fMRI
Journal
Brain, behavior, and immunity
ISSN: 1090-2139
Titre abrégé: Brain Behav Immun
Pays: Netherlands
ID NLM: 8800478
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
13
01
2021
revised:
08
05
2021
accepted:
25
05
2021
pubmed:
31
5
2021
medline:
7
8
2021
entrez:
30
5
2021
Statut:
ppublish
Résumé
Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen have shown initial promise in producing antidepressant effects. This is perhaps due to these drugs being peroxisome proliferator-activated receptor gamma (PPARγ) agonists, in addition to their inhibition of cyclooxygenase enzymes. Some, albeit mixed, evidence suggests that PPARγ agonists have antidepressant effects in humans and animals. This double-blind, placebo-controlled, pharmacologic functional magnetic resonance imaging (ph-fMRI) study aimed to elucidate the impact of ibuprofen on emotion-related neural activity and determine whether observed effects were due to changes in PPARγ gene expression. Twenty healthy volunteers completed an emotional face matching task during three fMRI sessions, conducted one week apart. Placebo, 200 mg, or 600 mg ibuprofen was administered 1 h prior to each scan in a pseudo-randomized order. Peripheral blood mononuclear cells were collected at each session to isolate RNA for PPARγ gene expression. At the doses used, ibuprofen did not significantly change PPARγ gene expression. Ibuprofen dose was associated with decreased blood oxygen level-dependent (BOLD) activation in the dorsolateral prefrontal cortex and fusiform gyrus during emotional face processing (faces-shapes). Additionally, PPARγ gene expression was associated with increased BOLD activation in the insula and transverse and superior temporal gyri (faces-shapes). No interaction effects between ibuprofen dose and PPARγ gene expression on BOLD activation were observed. Thus, results suggest that ibuprofen and PPARγ may have independent effects on emotional neurocircuitry. Future studies are needed to further delineate the roles of ibuprofen and PPARγ in exerting antidepressant effects in healthy as well as clinical populations.
Identifiants
pubmed: 34052365
pii: S0889-1591(21)00220-8
doi: 10.1016/j.bbi.2021.05.023
pmc: PMC8319138
mid: NIHMS1709726
pii:
doi:
Substances chimiques
PPAR gamma
0
Cyclooxygenase 2
EC 1.14.99.1
Ibuprofen
WK2XYI10QM
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-142Subventions
Organisme : NICHD NIH HHS
ID : F31 HD103340
Pays : United States
Organisme : NIMH NIH HHS
ID : K23 MH108707
Pays : United States
Organisme : NIGMS NIH HHS
ID : P20 GM121312
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH123691
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
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