Sleep and Metabolism: Implication of Lateral Hypothalamic Neurons.
Journal
Frontiers of neurology and neuroscience
ISSN: 1662-2804
Titre abrégé: Front Neurol Neurosci
Pays: Switzerland
ID NLM: 101274949
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
09
2020
accepted:
02
02
2021
entrez:
30
5
2021
pubmed:
31
5
2021
medline:
30
11
2021
Statut:
ppublish
Résumé
During the last decade, optogenetic-based circuit mapping has become one of the most common approaches to systems neuroscience, and amassing studies have expanded our understanding of brain structures causally involved in the regulation of sleep-wake cycles. Recent imaging technologies enable the functional mapping of cellular activity, from population down to single-cell resolution, across a broad repertoire of behaviors and physiological processes, including sleep-wake states. This chapter summarizes experimental evidence implicating hypocretins/orexins, melanin-concentrating hormone, and inhibitory neurons from the lateral hypothalamus (LH) in forming an intricate network involved in regulating sleep and metabolism, including feeding behaviors. It further confirms the dual sleep-metabolic functions of LH cells, and sheds light on a possible mechanism underlying brain plasticity during sleep and metabolic disorders.
Identifiants
pubmed: 34052816
pii: 000514966
doi: 10.1159/000514966
doi:
Substances chimiques
Hypothalamic Hormones
0
Melanins
0
Orexins
0
Pituitary Hormones
0
melanin-concentrating hormone
67382-96-1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
75-90Informations de copyright
© 2021 The Author(s). Published by S. Karger AG, Basel.