Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation.
Body Mass Index
Case-Control Studies
Diet
/ adverse effects
Female
Gastroenteritis
/ immunology
Humans
Immunity, Innate
Immunity, Mucosal
Inflammation Mediators
/ metabolism
Intestines
/ immunology
Macrophages
/ immunology
Male
Middle Aged
Obesity
/ complications
Phenotype
Prospective Studies
Risk Assessment
Risk Factors
Sedentary Behavior
Obesity
chronic inflammation
diabetes
intestinal inflammation
macrophages
metabolic disease
monocytes
mucosal immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
16
02
2021
accepted:
26
04
2021
entrez:
31
5
2021
pubmed:
1
6
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Chronic low-grade inflammation is a hallmark of obesity and associated with cardiovascular complications. However, it remains unclear where this inflammation starts. As the gut is constantly exposed to food, gut microbiota, and metabolites, we hypothesized that mucosal immunity triggers an innate inflammatory response in obesity. We characterized five distinct macrophage subpopulations (P1-P5) along the gastrointestinal tract and blood monocyte subpopulations (classical, non-classical, intermediate), which replenish intestinal macrophages, in non-obese (BMI<27kg/m
Identifiants
pubmed: 34054838
doi: 10.3389/fimmu.2021.668654
pmc: PMC8158297
doi:
Substances chimiques
Inflammation Mediators
0
Types de publication
Journal Article
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
668654Informations de copyright
Copyright © 2021 Rohm, Fuchs, Müller, Keller, Baumann, Bosch, Schneider, Labes, Langer, Pilz, Niess, Delko, Hruz and Cavelti-Weder.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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