Early detection of redox imbalance in the APPswe/PS1dE9 mouse model of Alzheimer's disease by in vivo electron paramagnetic resonance imaging.
Alzheimer's disease
Antioxidant
Brain redox status
Electron paramagnetic resonance (EPR) imaging
Oxidative stress
Journal
Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159
Informations de publication
Date de publication:
20 08 2021
20 08 2021
Historique:
received:
19
04
2021
revised:
14
05
2021
accepted:
25
05
2021
pubmed:
1
6
2021
medline:
20
8
2021
entrez:
31
5
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a common neurodegenerative disease that causes progressive cognitive decline. Deposition of amyloid-β (Aβ) peptides is the most important pathophysiological hallmark of AD. Oxidative stress induced by the generation of reactive oxygen species (ROS) is a prominent phenomenon in AD and is known to occur early in its course. Several reports have suggested a relationship between changes in redox status and AD pathology, including progressive Aβ deposition, glial cell activation, and inflammation. In the present study, we employed a newly designed three-dimensional continuous-wave digital electron paramagnetic resonance (EPR) imager with a blood-brain barrier (BBB)-permeable redox-sensitive piperidine nitroxide probe, 4-oxo-2,2,6,6-tetramethyl-piperidine-d
Identifiants
pubmed: 34058322
pii: S0891-5849(21)00327-0
doi: 10.1016/j.freeradbiomed.2021.05.035
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9-18Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.