High frequency repetitive Transcranial Magnetic Stimulation promotes long lasting phrenic motoneuron excitability via GABAergic networks.
Animals
Diaphragm
/ drug effects
Evoked Potentials, Motor
/ drug effects
Female
GABA-A Receptor Agonists
/ pharmacology
GABA-B Receptor Agonists
/ pharmacology
Motor Neurons
/ drug effects
Nerve Net
/ drug effects
Phrenic Nerve
/ drug effects
Rats
Rats, Sprague-Dawley
Transcranial Magnetic Stimulation
GABAergic modulation
Motoneuron excitability
Preclinical model
rTMS
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
17
12
2020
revised:
17
05
2021
accepted:
25
05
2021
pubmed:
1
6
2021
medline:
21
1
2022
entrez:
31
5
2021
Statut:
ppublish
Résumé
Repetitive transcranial magnetic stimulation (rTMS) is a promising, innovative, and non-invasive therapy used clinically. Efficacy of rTMS has been demonstrated to ameliorate psychiatric disorders and neuropathic pain through neuromodulation of affected neural circuits. However, little is known about the mechanisms and the specific neural circuits via which rTMS facilitates these functional effects. The aim of this study was to begin revealing the mechanisms by which rTMS may tap into existing neural circuits, by using a well characterized spinal motor circuit - the phrenic circuit. Here we hypothesized that rTMS can be used to enhance phrenic motoneuron excitability in anesthetized Sprague Dawley rats. Multiple acute rTMS protocols were used revealing 10 Hz rTMS protocol induced a robust, long-lasting increase in phrenic motoneuron excitability, functionally evaluated by diaphragm motor evoked potentials (59.1 ± 21.1 % of increase compared to baseline 60 min after 10 Hz protocol against 6.0 ± 5.8 % (p = 0.007) for Time Control, -5.8 ± 7.4 % (p < 0.001) for 3 Hz, and 5.2 ± 12.5 % (p = 0.008) for 30 Hz protocols). A deeper analyze allowed to discriminate "responder" and "non-responder" subgroups among 10 Hz rTMS treated animals. Intravenous injections of GABA
Identifiants
pubmed: 34058433
pii: S1569-9048(21)00089-6
doi: 10.1016/j.resp.2021.103704
pmc: PMC9447414
mid: NIHMS1830893
pii:
doi:
Substances chimiques
GABA-A Receptor Agonists
0
GABA-B Receptor Agonists
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
103704Subventions
Organisme : NINDS NIH HHS
ID : F32 NS119348
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS104291
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier B.V. All rights reserved.
Références
J Psychiatr Res. 2017 Jun;89:125-135
pubmed: 28278422
Neuroendocrinology. 1996 Apr;63(4):368-76
pubmed: 8739892
J Physiol. 1991 Nov;443:105-21
pubmed: 1822523
J Appl Physiol (1985). 2009 Apr;106(4):1257-63
pubmed: 19213928
Alcohol Clin Exp Res. 2015 Sep;39(9):1602-8
pubmed: 26207768
Brain Stimul. 2019 Mar - Apr;12(2):314-318
pubmed: 30545685
Respir Physiol Neurobiol. 2006 Dec;154(3):406-18
pubmed: 16406377
Exp Brain Res. 2009 Dec;199(3-4):411-21
pubmed: 19701632
Front Neurosci. 2020 Jun 16;14:558
pubmed: 32612497
Brain Behav. 2019 Jun;9(6):e01305
pubmed: 31033242
Exp Brain Res. 1986;61(2):280-90
pubmed: 3005015
Brain Struct Funct. 2015 Nov;220(6):3323-37
pubmed: 25108309
Neuropsychiatr Dis Treat. 2019 Sep 06;15:2579-2586
pubmed: 31564883
J Physiol. 1987 Mar;384:109-18
pubmed: 3656144
Curr Drug Targets. 2013 Mar;14(3):353-64
pubmed: 23256724
Nat Commun. 2016 Jan 08;7:10020
pubmed: 26743822
Pharmacopsychiatry. 2006 Mar;39(2):52-9
pubmed: 16555165
J Neurophysiol. 2015 Sep;114(3):1784-91
pubmed: 26224775
J Pain. 2014 Aug;15(8):845-55
pubmed: 24865417
Brain Stimul. 2010 Apr;3(2):95-118
pubmed: 20633438
Elife. 2018 Apr 24;7:
pubmed: 29688171
Psychiatr Clin North Am. 2018 Sep;41(3):433-446
pubmed: 30098656
J Appl Physiol (1985). 2003 Jan;94(1):358-74
pubmed: 12486024
PLoS One. 2016 Feb 01;11(2):e0148180
pubmed: 26828648
J Neurochem. 2008 Aug;106(3):1160-74
pubmed: 18466337
J Auton Pharmacol. 1992 Jun;12(3):149-56
pubmed: 1321154
Depress Anxiety. 2017 Nov;34(11):1029-1039
pubmed: 28543994
J Physiol Pharmacol. 2007 Nov;58 Suppl 5(Pt 1):17-23
pubmed: 18204111
Brain Stimul. 2017 Jul - Aug;10(4):847-849
pubmed: 28330592
Neuroscientist. 2017 Feb;23(1):82-94
pubmed: 26643579
J Comp Neurol. 2008 Dec 10;511(5):692-709
pubmed: 18924146
PLoS One. 2014 Nov 18;9(11):e113251
pubmed: 25406091
J Neurosci. 2011 Jan 26;31(4):1193-203
pubmed: 21273404
J Appl Physiol (1985). 2003 Jul;95(1):26-34
pubmed: 12639850
Eur J Pharmacol. 1996 Jun 20;307(1):89-96
pubmed: 8831109
Neurosci Lett. 2017 Mar 6;642:37-42
pubmed: 28159637
Respir Physiol Neurobiol. 2019 Jul;265:24-31
pubmed: 30315961
Neurobiol Learn Mem. 2016 Oct;134 Pt B:369-78
pubmed: 27555233
Drugs. 1976 Nov;12(5):321-61
pubmed: 976134
J Appl Physiol (1985). 2012 Oct 15;113(8):1184-93
pubmed: 22961271
Brain Stimul. 2008 Jul;1(3):164-82
pubmed: 20633383
PLoS One. 2016 May 11;11(5):e0155343
pubmed: 27168145
Am J Transl Res. 2016 May 15;8(5):2301-8
pubmed: 27347337
J Physiol. 2008 Dec 1;586(23):5717-25
pubmed: 18845611
Eur J Appl Physiol. 2001 Oct;85(6):560-6
pubmed: 11718285
J Physiol. 1973 Jul;232(2):357-74
pubmed: 4727085
Exp Brain Res. 1998 Sep;122(2):149-56
pubmed: 9776513
Brain Stimul. 2013 Jul;6(4):598-606
pubmed: 23433874
Depress Anxiety. 2016 Aug;33(8):746-53
pubmed: 27059158
Neurosci Lett. 1989 Dec 15;107(1-3):239-44
pubmed: 2559370
Psychiatry Res. 2017 Dec;258:226-233
pubmed: 28844559
J Neurol Sci. 1994 Jul;124(2):204-7
pubmed: 7964872
Nat Neurosci. 2004 Jan;7(1):48-55
pubmed: 14699417
J Neurosci. 2012 Nov 28;32(48):17514-23
pubmed: 23197741
Trends Neurosci. 2018 Sep;41(9):625-639
pubmed: 30017476
J Clin Psychiatry. 2018 Jan/Feb;79(1):
pubmed: 28541649
Exp Brain Res. 2007 Jun;180(1):181-6
pubmed: 17351767
Front Neural Circuits. 2016 Nov 28;10:96
pubmed: 27965542
J Physiol. 1973 Jul;232(2):331-56
pubmed: 4727084
Acta Neurol Scand. 2017 Dec;136(6):585-605
pubmed: 28464421
Curr Pharm Des. 2013;19(24):4471-84
pubmed: 23360277
Respir Physiol. 1996 Nov;106(2):127-35
pubmed: 8971986
J Appl Physiol (1985). 2011 May;110(5):1299-310
pubmed: 21372099
Crit Rev Phys Rehabil Med. 2013;25(1-2):11-22
pubmed: 25750484
J Neurosci. 1999 Apr 15;19(8):3198-203
pubmed: 10191332
Respir Physiol Neurobiol. 2013 Nov 1;189(2):438-49
pubmed: 23751522