Ectopic pregnancy: a single-center experience over ten years.


Journal

Reproductive biology and endocrinology : RB&E
ISSN: 1477-7827
Titre abrégé: Reprod Biol Endocrinol
Pays: England
ID NLM: 101153627

Informations de publication

Date de publication:
01 Jun 2021
Historique:
received: 16 04 2021
accepted: 12 05 2021
entrez: 1 6 2021
pubmed: 2 6 2021
medline: 1 1 2022
Statut: epublish

Résumé

The aim of this study was to investigate characteristics associated with ectopic pregnancy (EP) that could be utilized for predicting morbidity or mortality. This was a retrospective analysis of pregnancy-related records from a tertiary center over a period of ten years. Data on age, gravidity, parity, EP risk, amenorrhea duration, abdominal pain presence and location, β-human chorionic gonadotropin (β-HCG) level, ultrasound findings, therapeutic intervention, exact EP implantation site and length of hospital stay (LOS) were obtained from the database. The LOS was used as a proxy for morbidity and was tested for an association with all variables. All statistical analyses were conducted with Stata® (ver. 16.1, Texas, USA). The incidence of EP in a cohort of 30,247 pregnancies over a ten-year period was 1.05%. Patients presented with lower abdominal pain in 87.9% of cases, and the likelihood of experiencing pain was tenfold higher if fluid was detectable in the pouch of Douglas. Only 5.1% of patients had a detectable embryonic heartbeat, and 18.15% had one or more risk factors for EP. While most EPs were tubal, 2% were ovarian. The LOS was 1.9 days, and laparoscopic intervention was the main management procedure. The cohort included one genetically proven dizygotic heterotopic pregnancy (incidence, 3.3 × 10 EP is a relatively common condition affecting approximately 1% of all pregnancies. β-HCG correlates with EP-related morbidity, but the overall morbidity rate of EP is low regardless of the implantation site. Laparoscopic surgery is an effective therapeutic procedure that is safe for managing EP, even in cases of heterotopic pregnancy.

Identifiants

pubmed: 34059064
doi: 10.1186/s12958-021-00761-w
pii: 10.1186/s12958-021-00761-w
pmc: PMC8166577
doi:

Substances chimiques

Abortifacient Agents, Nonsteroidal 0
Chorionic Gonadotropin, beta Subunit, Human 0
Methotrexate YL5FZ2Y5U1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

79

Références

MMWR Morb Mortal Wkly Rep. 1995 Jan 27;44(3):46-8
pubmed: 7823895
Contracept Fertil Sex. 1993 Apr;21(4):307-12
pubmed: 7951631
Cureus. 2021 Feb 2;13(2):e13089
pubmed: 33728112
Obstet Gynecol Surv. 2013 Aug;68(8):571-81
pubmed: 23921671
Eur J Obstet Gynecol Reprod Biol. 2014 Sep;180:157-61
pubmed: 25012396
J Obstet Gynaecol. 2014 Aug;34(6):508-11
pubmed: 24766292
J Clin Ultrasound. 2010 Nov-Dec;38(9):509-11
pubmed: 20812341
Obstet Gynecol. 2008 Jun;111(6):1479-85
pubmed: 18515537
Obstet Gynecol Surv. 1986 Oct;41(10):603-13
pubmed: 3774265
PLoS One. 2019 Jun 5;14(6):e0217674
pubmed: 31166967
Am J Obstet Gynecol. 1948 Dec;56(6):1119-26
pubmed: 18893768
Gynecol Minim Invasive Ther. 2021 Jan 30;10(1):53-56
pubmed: 33747776
J Obstet Gynaecol. 2019 Jul;39(5):670-674
pubmed: 30915881
Fertil Steril. 1996 Jul;66(1):1-12
pubmed: 8752602
Am J Obstet Gynecol. 1999 Apr;180(4):938-44
pubmed: 10203662
Hum Reprod. 2002 Dec;17(12):3224-30
pubmed: 12456628
Eur J Obstet Gynecol Reprod Biol. 2018 Dec;231:174-179
pubmed: 30391866
J Minim Invasive Gynecol. 2011 Mar-Apr;18(2):179-83
pubmed: 21277264
Semin Reprod Med. 2007 Mar;25(2):93-8
pubmed: 17377896
Epidemiol Rev. 1987;9:70-94
pubmed: 3315720
J Hum Reprod Sci. 2013 Jan;6(1):70-3
pubmed: 23869156
Fertil Steril. 2013 Sep;100(3):638-44
pubmed: 23849842
Ultrasound Obstet Gynecol. 2004 Mar;23(3):247-53
pubmed: 15027012
Am J Obstet Gynecol. 1993 Jun;168(6 Pt 1):1759-62; discussion 1762-5
pubmed: 8317518
Eur J Obstet Gynecol Reprod Biol. 2021 Apr;259:95-99
pubmed: 33636621
Am J Obstet Gynecol. 1990 Oct;163(4 Pt 1):1182-5
pubmed: 2220925

Auteurs

Ammar Al Naimi (A)

Department of Obstetrics and Gynecology, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Hessen, Germany. ammar.alnaimi@uclmail.net.
Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenbergische Stiftung, Nibelungenallee 37-41, D-60318, Frankfurt am Main, Hessen, Germany. ammar.alnaimi@uclmail.net.

Pablo Moore (P)

High Risk Pregnancy Unit, University Hospital of Puerto Montt, Puerto Montt, Chile.

Dörthe Brüggmann (D)

Department of Obstetrics and Gynecology, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Hessen, Germany.

Lisa Krysa (L)

Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenbergische Stiftung, Nibelungenallee 37-41, D-60318, Frankfurt am Main, Hessen, Germany.

Frank Louwen (F)

Department of Obstetrics and Gynecology, University Hospital, Goethe University Frankfurt am Main, Frankfurt, Hessen, Germany.

Franz Bahlmann (F)

Department of Obstetrics and Gynecology, Buergerhospital - Dr. Senckenbergische Stiftung, Nibelungenallee 37-41, D-60318, Frankfurt am Main, Hessen, Germany.

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Classifications MeSH