An Update on the Pathogenesis of COVID-19 and the Reportedly Rare Thrombotic Events Following Vaccination.
Ad26COVS1
Autoantibodies
/ biosynthesis
BNT162 Vaccine
COVID-19
/ epidemiology
COVID-19 Vaccines
/ adverse effects
ChAdOx1 nCoV-19
Clinical Trials as Topic
Disseminated Intravascular Coagulation
/ epidemiology
Drug Approval
Female
Genetic Vectors
Glycosaminoglycans
/ immunology
Humans
Male
Models, Cardiovascular
Pandemics
/ prevention & control
Platelet Factor 4
/ immunology
SARS-CoV-2
/ genetics
Safety
Sinus Thrombosis, Intracranial
/ epidemiology
Thrombosis
/ epidemiology
Vaccines, Inactivated
/ adverse effects
Vaccines, Synthetic
/ adverse effects
mRNA Vaccines
COVID-19
SARS-CoV-2
heparin induced thrombocytopenia
safety and efficacy
thrombocytopenia
thrombosis
Journal
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
ISSN: 1938-2723
Titre abrégé: Clin Appl Thromb Hemost
Pays: United States
ID NLM: 9508125
Informations de publication
Date de publication:
Historique:
entrez:
1
6
2021
pubmed:
2
6
2021
medline:
4
6
2021
Statut:
ppublish
Résumé
Today the coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has become a global health problem. After more than a year with the pandemic, although our knowledge has progressed on COVID-19, there are still many unknowns in virological, pathophysiological and immunological aspects. It is obvious that the most efficient solution to end this pandemic are safe and efficient vaccines. This manuscript summarizes the pathophysiological and thrombotic features of COVID-19 and the safety and efficacy of currently approved COVID-19 vaccines with an aim to clarify the recent concerns of thromboembolic events after COVID-19 vaccination. The influx of newer information is rapid, requiring periodic updates and objective assessment of the data on the pathogenesis of COVID-19 variants and the safety and efficacy of currently available vaccines.
Identifiants
pubmed: 34060379
doi: 10.1177/10760296211021498
pmc: PMC8173993
doi:
Substances chimiques
Ad26COVS1
JT2NS6183B
Autoantibodies
0
COVID-19 Vaccines
0
Glycosaminoglycans
0
PF4 protein, human
0
Vaccines, Inactivated
0
Vaccines, Synthetic
0
NVX-CoV2373 adjuvated lipid nanoparticle
2SCD8Q63PF
Platelet Factor 4
37270-94-3
ChAdOx1 nCoV-19
B5S3K2V0G8
BNT162 Vaccine
N38TVC63NU
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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