Ironing out mechanisms of iron homeostasis and disorders of iron deficiency.
Journal
The Journal of clinical investigation
ISSN: 1558-8238
Titre abrégé: J Clin Invest
Pays: United States
ID NLM: 7802877
Informations de publication
Date de publication:
01 06 2021
01 06 2021
Historique:
entrez:
1
6
2021
pubmed:
2
6
2021
medline:
5
10
2021
Statut:
ppublish
Résumé
Iron plays an important role in mammalian physiological processes. It is a critical component for the function of many proteins, including enzymes that require heme and iron-sulfur clusters. However, excess iron is also detrimental because of its ability to catalyze the formation of reactive oxygen species. As a result, cellular and systemic iron levels are tightly regulated to prevent oxidative damage. Iron deficiency can lead to a number of pathological conditions, the most prominent being anemia. Iron deficiency should be corrected to improve adult patients' symptoms and to facilitate normal growth during fetal development and childhood. However, inappropriate use of intravenous iron in chronic conditions, such as cancer and heart failure, in the absence of clear iron deficiency can lead to unwanted side effects. Thus, this form of therapy should be reserved for certain patients who cannot tolerate oral iron and need rapid iron replenishment. Here, we will review cellular and systemic iron homeostasis and will discuss complications of iron deficiency.
Identifiants
pubmed: 34060484
pii: e148671
doi: 10.1172/JCI148671
pmc: PMC8159681
doi:
pii:
Substances chimiques
Reactive Oxygen Species
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140973
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL138982
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007169
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008152
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM144295
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140927
Pays : United States
Commentaires et corrections
Type : CommentIn
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