Gout and Levodopa: An unknown adverse effect?

Aged Gout / drug therapy Gout Suppressants / adverse effects Humans Levodopa / adverse effects Male Symptom Flare Up Treatment Outcome
Levodopa crystal arthropathies drug-induced rheumatic disease

Journal

Fundamental & clinical pharmacology
ISSN: 1472-8206
Titre abrégé: Fundam Clin Pharmacol
Pays: England
ID NLM: 8710411

Informations de publication

Date de publication:
Feb 2022
Historique:
revised: 05 05 2021
received: 09 03 2021
accepted: 24 05 2021
pubmed: 2 6 2021
medline: 18 1 2022
entrez: 1 6 2021
Statut: ppublish

Résumé

We report the case of a 77-year-old man with Parkinson's disease (PD) who experimented for the first time gout crisis after the initiation of levodopa. Levodopa was withdrawn, and colchicine and allopurinol were initiated to treat the gout crisis. Because of PD progression, levodopa was reintroduced, and the patient presented relapse of gout flare. To further explore the association between gout and levodopa, we extracted and synthetized all Individual Case Safety Reports of gout associated with levodopa in the World Health Organization pharmacovigilance database, VigiBase

Identifiants

DOI: 10.1111/fcp.12706 PMID: 34062024
pubmed: 34062024
doi: 10.1111/fcp.12706
doi:

Substances chimiques

Gout Suppressants 0
Levodopa 46627O600J

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

221-223

Informations de copyright

© 2021 Société Française de Pharmacologie et de Thérapeutique.

Références

Bégaud B, Evreux JC, Jouglard J, Lagier G. [Imputation of the unexpected or toxic effects of drugs. Actualization of the method used in France]. Therapie. 1985;40:111-118.
Xie C, Zhang Y-Y, Wang X-D et al. Levodopa alone compared with levodopa-sparing therapy as initial treatment for Parkinson’s disease: a meta-analysis. Neurol Sci. 2015;36:1319-1329.
Honda H, Gindin RA. Gout while receiving levodopa for Parkinsonism. JAMA. 1972;219:55-57.
Bierer DW, Quebbemann AJ. Effect of L-dopa on renal handling of uric acid. J Pharmacol Exp Ther. 1982;223:55-59.
Cawein MJ, Hewins J. False rise in serum uric acid after L-dopa. N Engl J Med. 1969;281:1489-1490.
Sakuta H, Suzuki K, Miyamoto T et al. Serum uric acid levels in Parkinson’s disease and related disorders. Brain Behav [Internet]. 2017;7:e00598. http://doi.wiley.com/10.1002/brb3.598.
Ben Salem C, Slim R, Fathallah N, Hmouda H. Drug-induced hyperuricaemia and gout. Rheumatology. 2016;56:679-688.
Dalbeth N, Merriman TR, Stamp LK. Gout. Lancet Lond Engl. 2016;388:2039-2052.
Urano W, Yamanaka H, Tsutani H et al. The inflammatory process in the mechanism of decreased serum uric acid concentrations during acute gouty arthritis. J Rheumatol. 2002;29:1950-1953.
Logan JA, Morrison E, McGill PE. Serum uric acid in acute gout. Ann Rheum Dis. 1997;56:696-697.

Auteurs

Laura Quarteroni (L)

Pharmacy Unit, CHU of Grenoble Alpes, La Tronche, France.
ORCID: 0000-0002-4336-597X

Romain Gastaldi (R)

Rheumatology Department, Hôpital Sud CHU of Grenoble Alpes, La Tronche, France.

Athan Baillet (A)

Rheumatology Department, Hôpital Sud CHU of Grenoble Alpes, La Tronche, France.
Univ. Grenoble-Alpes, GREPI TIMC-IMAG (UMR CNRS 5525), UGA, Grenoble, France.

Elena Moro (E)

Division of Neurology, CHU of Grenoble, Boulevard de la Chantourne, La Tronche, France.
Univ. Grenoble-Alpes, Grenoble Institute of Neuroscience, Grenoble, France.

Benoit Allenet (B)

Pharmacy Unit, CHU of Grenoble Alpes, La Tronche, France.
Univ. Grenoble-Alpes, ThEMAS TIMC-IMAG (UMR CNRS 5525), UGA, Grenoble, France.

Charles Khouri (C)

Pharmacovigilance Unit, Grenoble Alpes University Hospital, Grenoble, France.
U 1300-HP2 Laboratory, INSERM, Univ. Grenoble Alpes, Grenoble, France.
ORCID: 0000-0002-8427-8573

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Erreurs innées du métabolisme de la purine et de la pyrimidine › Goutte › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Antigoutteux › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés cycliques › Acides aminés aromatiques › Tyrosine › Dopa › Lévodopa › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Récidive › Aggravation transitoire des symptômes › Gout and Levodopa: An unknown adverse effect?
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › Gout and Levodopa: An unknown adverse effect?