Single and combined effects of regulated and emerging mycotoxins on viability and mitochondrial function of SH-SY5Y cells.
Antagonistic
Apoptosis
Cytotoxicity
Emerging
Mycotoxin
Journal
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
ISSN: 1873-6351
Titre abrégé: Food Chem Toxicol
Pays: England
ID NLM: 8207483
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
01
03
2021
revised:
19
05
2021
accepted:
25
05
2021
pubmed:
2
6
2021
medline:
9
11
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
Co-occurrence of emerging and regulated mycotoxins in contaminated samples has been widely documented, but studies about their combined toxicity are scarce. In this report, the regulated mycotoxins deoxynivalenol, fumonisin B1 and zearalenone, and the emerging ones enniatin A, enniatin B and beauvericin were tested in SH-SY5Y human neuroblastoma cells. Their individual and binary combined effects on cell viability and mitochondrial function were evaluated. The results with individual mycotoxins revealed that deoxynivalenol and emerging mycotoxins were the most damaging to neuronal cells, presenting IC
Identifiants
pubmed: 34062223
pii: S0278-6915(21)00341-0
doi: 10.1016/j.fct.2021.112308
pii:
doi:
Substances chimiques
Mycotoxins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
112308Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.