Polyphenols as adjunctive treatments in psychiatric and neurodegenerative disorders: Efficacy, mechanisms of action, and factors influencing inter-individual response.

Gastrointestinal Microbiome Humans Neurodegenerative Diseases / drug therapy Polyphenols / therapeutic use
Flavonoid Mechanisms Microbiome Neurodegeneration Nutritional psychiatry Psychiatry

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
20 08 2021
Historique:
received: 16 03 2021
revised: 14 05 2021
accepted: 26 05 2021
pubmed: 2 6 2021
medline: 20 8 2021
entrez: 1 6 2021
Statut: ppublish

Résumé

The pathophysiology of psychiatric and neurodegenerative disorders is complex and multifactorial. Polyphenols possess a range of potentially beneficial mechanisms of action that relate to the implicated pathways in psychiatric and neurodegenerative disorders. The aim of this review is to highlight the emerging clinical trial and preclinical efficacy data regarding the role of polyphenols in mental and brain health, elucidate novel mechanisms of action including the gut microbiome and gene expression, and discuss the factors that may be responsible for the mixed clinical results; namely, the role of interindividual differences in treatment response and the potentially pro-oxidant effects of some polyphenols. Further clarification as part of larger, well conducted randomized controlled trials that incorporate precision medicine methods are required to inform clinical efficacy and optimal dosing regimens.

Identifiants

DOI: 10.1016/j.freeradbiomed.2021.05.036 PMID: 34062263
pubmed: 34062263
pii: S0891-5849(21)00347-6
doi: 10.1016/j.freeradbiomed.2021.05.036
pii:
doi:

Substances chimiques

Polyphenols 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

101-122

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Auteurs

Gerwyn Morris (G)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Elizabeth Gamage (E)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Nikolaj Travica (N)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Michael Berk (M)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Felice N Jacka (FN)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Adrienne O'Neil (A)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Basant K Puri (BK)

C.A.R, Cambridge, UK.

Andre F Carvalho (AF)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Chiara C Bortolasci (CC)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Ken Walder (K)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia.

Wolfgang Marx (W)

Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health, Geelong, Australia. Electronic address: wolf.marx@deakin.edu.au.

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Classifications MeSH

questionsmedicales.fr › Environnement et santé publique › Environnement › Écosystème › Biodiversité › Biote › Microbiote › Microbiome gastro-intestinal › Polyphenols as adjunctive treatments in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Polyphenols as adjunctive treatments in...
questionsmedicales.fr › Maladies du système nerveux › Maladies neurodégénératives › Polyphenols as adjunctive treatments in...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Phénols › Polyphénols › Polyphenols as adjunctive treatments in...