A qualitative and quantitative comparison of Crocus sativus and Nigella sativa immunomodulatory effects.
Black seed
Crocin
Crocus sativus
Kaempferol
Nigella sativa
Safranal
The immune system
Journal
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
06
04
2021
revised:
17
05
2021
accepted:
24
05
2021
pubmed:
2
6
2021
medline:
11
8
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
The present article reviews and compares the immunomodulatory activities of Crocus sativus (C. sativus) and Nigella sativa (N. sativa) and their main bioactive compounds. Immunomodulatory effects of these plants, especially with respect to Th1 and Th2 cytokines, are discussed based on relevant articles, books, and conference papers published in English until the end of April 2020, that were retrieved from Web of Science, PubMed, Scopus and Google Scholar databases. C. sativus and its constituents increase immunoglobulin (Ig-)G, interleukin 2 (IL)-2, interferon gamma (IFN-γ), and IFN-γ/IL-4 ratio, but decreased IgM, IL-10 and IL-4 secretion. N. sativa extract and thymoquinone reduce the levels of IL-2, -4, -10, and -12, while enhance IFN-γ and serum IgG1 and 2a. The reviewed articles indicate that C. sativus and N. sativa and their constituents could be potentially considered promising treatments for disorders associated with immune-dysregulation such as asthma and cancer.
Identifiants
pubmed: 34062409
pii: S0753-3322(21)00556-4
doi: 10.1016/j.biopha.2021.111774
pii:
doi:
Substances chimiques
Immunologic Factors
0
Phytochemicals
0
Plant Extracts
0
Types de publication
Comparative Study
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
111774Informations de copyright
Copyright © 2021 The Authors. Published by Elsevier Masson SAS.. All rights reserved.