The Impact of Chlorambucil and Valproic Acid on Cell Viability, Apoptosis and Expression of
Aged
Aged, 80 and over
Apoptosis
/ drug effects
Cell Survival
/ drug effects
Chlorambucil
/ administration & dosage
Cyclin-Dependent Kinase Inhibitor p21
/ biosynthesis
Cytogenetics
Female
Gene Expression Profiling
Gene Expression Regulation, Leukemic
Humans
Leukemia, Lymphocytic, Chronic, B-Cell
/ drug therapy
Leukocytes, Mononuclear
/ cytology
Male
Middle Aged
Myeloid Cell Leukemia Sequence 1 Protein
/ biosynthesis
Prognosis
Proto-Oncogene Proteins c-bcl-2
/ biosynthesis
Proto-Oncogene Proteins c-mdm2
/ biosynthesis
Valproic Acid
/ administration & dosage
T53 and Bcl-2 family genes
apoptosis
chlorambucil and valproic acid
chronic lymphocytic leukemia
cytogenetic prognostics
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 05 2021
02 05 2021
Historique:
received:
28
03
2021
revised:
28
04
2021
accepted:
30
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
16
11
2021
Statut:
epublish
Résumé
Malignant cells in chronic lymphocytic leukemia (CLL) show resistance to apoptosis, as well as to chemotherapy, which are related to deletions or mutations of
Identifiants
pubmed: 34063233
pii: cells10051088
doi: 10.3390/cells10051088
pmc: PMC8147495
pii:
doi:
Substances chimiques
BCL2 protein, human
0
CDKN1A protein, human
0
Cyclin-Dependent Kinase Inhibitor p21
0
MCL1 protein, human
0
Myeloid Cell Leukemia Sequence 1 Protein
0
Proto-Oncogene Proteins c-bcl-2
0
Chlorambucil
18D0SL7309
Valproic Acid
614OI1Z5WI
MDM2 protein, human
EC 2.3.2.27
Proto-Oncogene Proteins c-mdm2
EC 2.3.2.27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
Exp Hematol. 2007 Oct;35(10):1527-37
pubmed: 17697742
Toxicol Pathol. 2007 Jun;35(4):495-516
pubmed: 17562483
Mediterr J Hematol Infect Dis. 2013 May 02;5(1):e2013031
pubmed: 23667729
Leuk Lymphoma. 2015 Jun;56(6):1585-92
pubmed: 25219593
Leukemia. 2009 Dec;23(12):2281-9
pubmed: 19710697
N Engl J Med. 2020 Jul 30;383(5):460-473
pubmed: 32726532
Adv Clin Exp Med. 2015 Jan-Feb;24(1):55-62
pubmed: 25923087
Br J Haematol. 2017 Sep;178(6):852-870
pubmed: 28444740
Curr Med Chem. 2014;21(5):553-74
pubmed: 24180275
Cell Death Differ. 2018 Jan;25(1):104-113
pubmed: 29149101
Ther Adv Hematol. 2019 Dec 5;10:2040620719891356
pubmed: 31839919
Biomed Res Int. 2014;2014:435983
pubmed: 24967369
Oncol Lett. 2013 Nov;6(5):1492-1498
pubmed: 24179547
Cancers (Basel). 2019 Aug 14;11(8):
pubmed: 31416295
Apoptosis. 2014 Jan;19(1):191-200
pubmed: 24057147
J Clin Pathol. 2019 May;72(5):343-346
pubmed: 30712002
Curr Mol Pharmacol. 2019;12(1):72-81
pubmed: 30318011
Lancet Oncol. 2019 Jan;20(1):43-56
pubmed: 30522969
Mol Med. 2008 Jan-Feb;14(1-2):20-7
pubmed: 17973028
Oncotarget. 2017 Jan 31;8(5):8921-8946
pubmed: 27888811
Br J Cancer. 2007 Jul 16;97(2):177-82
pubmed: 17579623
Am J Hematol. 2014 May;89(5):480-6
pubmed: 24415640
Br J Haematol. 2018 Dec;183(5):727-735
pubmed: 30460980
J Clin Oncol. 2014 Apr 20;32(12):1236-41
pubmed: 24638012
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
Clin Exp Med. 2015 Feb;15(1):73-83
pubmed: 24337970
J Biochem. 2015 Feb;157(2):101-11
pubmed: 25261582
Cell Biol Int. 2019 Jun;43(6):582-592
pubmed: 30958602
Hemasphere. 2019 Feb 09;3(2):e175
pubmed: 31723816
Blood. 2018 Sep 20;132(12):1248-1264
pubmed: 30012635
Acta Pharm. 2020 Sep 1;70(3):291-301
pubmed: 32074065
Am J Hematol. 2019 Nov;94(11):1266-1287
pubmed: 31364186
Oncogene. 2003 Nov 13;22(51):8356-69
pubmed: 14614459
Leuk Lymphoma. 2017 Mar;58(3):726-728
pubmed: 27686405