Pathogenesis and Management of COVID-19.
COVID-19
SARS-COV-2
cytokine storm
pharmacology
virus
Journal
Journal of xenobiotics
ISSN: 2039-4713
Titre abrégé: J Xenobiot
Pays: Switzerland
ID NLM: 101701430
Informations de publication
Date de publication:
21 May 2021
21 May 2021
Historique:
received:
22
04
2021
revised:
11
05
2021
accepted:
12
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
3
6
2021
Statut:
epublish
Résumé
COVID-19, occurring due to SARS-COV-2 infection, is the most recent pandemic disease that has led to three million deaths at the time of writing. A great deal of effort has been directed towards altering the virus trajectory and/or managing the interactions of the virus with its subsequent targets in the human body; these interactions can lead to a chain reaction-like state manifested by a cytokine storm and progress to multiple organ failure. During cytokine storms the ratio of pro-inflammatory to anti-inflammatory mediators is generally increased, which contributes to the instigation of hyper-inflammation and confers advantages to the virus. Because cytokine expression patterns fluctuate from one person to another and even within the same person from one time to another, we suggest a road map of COVID-19 management using an individual approach instead of focusing on the blockbuster process (one treatment for most people, if not all). Here, we highlight the biology of the virus, study the interaction between the virus and humans, and present potential pharmacological and non-pharmacological modulators that might contribute to the global war against SARS-COV-2. We suggest an algorithmic roadmap to manage COVID-19.
Identifiants
pubmed: 34063739
pii: jox11020006
doi: 10.3390/jox11020006
pmc: PMC8163157
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
77-93Références
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