Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy.
Cell Proliferation
Cytokines
/ metabolism
Humans
Immune Tolerance
Immunologic Factors
/ pharmacology
Immunosuppression Therapy
Immunosuppressive Agents
/ therapeutic use
Immunotherapy
/ methods
Microbiota
Models, Biological
Myeloid Cells
Myeloid-Derived Suppressor Cells
/ cytology
Neoplasms
/ immunology
Reactive Oxygen Species
Tumor Microenvironment
/ immunology
MDSCs
T-cells
anti-PD-1
cancer
immunotherapy
tumors
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
11 05 2021
11 05 2021
Historique:
received:
30
03
2021
revised:
01
05
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
16
11
2021
Statut:
epublish
Résumé
The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.
Identifiants
pubmed: 34065010
pii: cells10051170
doi: 10.3390/cells10051170
pmc: PMC8150533
pii:
doi:
Substances chimiques
Cytokines
0
Immunologic Factors
0
Immunosuppressive Agents
0
Reactive Oxygen Species
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : MOP#389137
Pays : Canada
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