CRL4-DCAF12 Ubiquitin Ligase Controls MOV10 RNA Helicase during Spermatogenesis and T Cell Activation.
Animals
Antigens, Neoplasm
/ metabolism
CD4-Positive T-Lymphocytes
/ metabolism
Cell Line
Cell Line, Tumor
HCT116 Cells
HEK293 Cells
HeLa Cells
Humans
Lymphocyte Activation
/ physiology
Mice, Inbred C57BL
Mice, Knockout
Natural Killer T-Cells
/ metabolism
Proteasome Endopeptidase Complex
/ metabolism
RNA Helicases
/ metabolism
Spermatogenesis
/ physiology
Ubiquitin
/ metabolism
Ubiquitin-Protein Ligases
/ metabolism
C-terminal degron
DCAF12
MOV10
T cell activation
WDR40A
spermatogenesis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 May 2021
20 May 2021
Historique:
received:
24
04
2021
revised:
12
05
2021
accepted:
16
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
22
6
2021
Statut:
epublish
Résumé
Multisubunit cullin-RING ubiquitin ligase 4 (CRL4)-DCAF12 recognizes the C-terminal degron containing acidic amino acid residues. However, its physiological roles and substrates are largely unknown. Purification of CRL4-DCAF12 complexes revealed a wide range of potential substrates, including MOV10, an "ancient" RNA-induced silencing complex (RISC) complex RNA helicase. We show that DCAF12 controls the MOV10 protein level via its C-terminal motif in a proteasome- and CRL-dependent manner. Next, we generated
Identifiants
pubmed: 34065512
pii: ijms22105394
doi: 10.3390/ijms22105394
pmc: PMC8161014
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
DCAF12 protein, human
0
IL17RB protein, human
0
Ubiquitin
0
Ubiquitin-Protein Ligases
EC 2.3.2.27
Mov10 protein, human
EC 2.7.7.-
Proteasome Endopeptidase Complex
EC 3.4.25.1
RNA Helicases
EC 3.6.4.13
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Grantová Agentura České Republiky
ID : 18-27408S
Organisme : Grantová Agentura, Univerzita Karlova
ID : 6119
Organisme : Ministry of Education, Youth and Science
ID : MEYS - LM2018129
Organisme : Ministry of Education, Youth and Science
ID : MEYS - CZ.02.1.01/0.0/0.0/18_046/0016045
Organisme : Ministry of Education, Youth and Science
ID : LO1220
Organisme : Ministry of Education, Youth and Science
ID : LO1419
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