Multi-Nutrient Fortified Dairy-Based Drink Reduces Anaemia without Observed Adverse Effects on Gut Microbiota in Anaemic Malnourished Nigerian Toddlers: A Randomised Dose-Response Study.
Anemia, Iron-Deficiency
/ epidemiology
Beverages
Child Nutrition Disorders
/ epidemiology
Child, Preschool
Dairy Products
Dose-Response Relationship, Drug
Female
Ferrous Compounds
/ administration & dosage
Food, Fortified
Gastrointestinal Microbiome
/ drug effects
Humans
Infant
Male
Micronutrients
/ administration & dosage
Nigeria
/ epidemiology
Prevalence
Nigeria
anaemia
iron deficiency
iron deficiency anaemia
malnourished
microbiota
multi-nutrient fortified dairy-based drink
toddler
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
06 May 2021
06 May 2021
Historique:
received:
26
02
2021
revised:
15
04
2021
accepted:
27
04
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
21
7
2021
Statut:
epublish
Résumé
Prevalence of anaemia among Nigerian toddlers is reported to be high, and may cause significant morbidity, affects brain development and function, and results in weakness and fatigue. Although, iron fortification can reduce anaemia, yet the effect on gut microbiota is unclear. This open-label randomised study in anaemic malnourished Nigerian toddlers aimed to decrease anaemia without affecting pathogenic gut bacteria using a multi-nutrient fortified dairy-based drink. The test product was provided daily in different amounts (200, 400 or 600 mL, supplying 2.24, 4.48 and 6.72 mg of elemental iron, respectively) for 6 months. Haemoglobin, ferritin, and C-reactive protein concentrations were measured to determine anaemia, iron deficiency (ID) and iron deficiency anaemia (IDA) prevalence. Faecal samples were collected to analyse gut microbiota composition. All three dosages reduced anaemia prevalence, to 47%, 27% and 18%, respectively. ID and IDA prevalence was low and did not significantly decrease over time. Regarding gut microbiota,
Identifiants
pubmed: 34066577
pii: nu13051566
doi: 10.3390/nu13051566
pmc: PMC8148581
pii:
doi:
Substances chimiques
Ferrous Compounds
0
Micronutrients
0
ferrous sulfate
39R4TAN1VT
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : FrieslandCampina Amersfoort, The Netherlands
ID : NA
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