Food Allergy and Intolerance: A Narrative Review on Nutritional Concerns.
food allergy
food intolerance
nutrition
nutritional concerns
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
13 May 2021
13 May 2021
Historique:
received:
07
04
2021
revised:
05
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
23
7
2021
Statut:
epublish
Résumé
Adverse food reactions include immune-mediated food allergies and non-immune-mediated intolerances. However, this distinction and the involvement of different pathogenetic mechanisms are often confused. Furthermore, there is a discrepancy between the perceived vs. actual prevalence of immune-mediated food allergies and non-immune reactions to food that are extremely common. The risk of an inappropriate approach to their correct identification can lead to inappropriate diets with severe nutritional deficiencies. This narrative review provides an outline of the pathophysiologic and clinical features of immune and non-immune adverse reactions to food-along with general diagnostic and therapeutic strategies. Special emphasis is placed on specific nutritional concerns for each of these conditions from the combined point of view of gastroenterology and immunology, in an attempt to offer a useful tool to practicing physicians in discriminating these diverging disease entities and planning their correct management. We conclude that a correct diagnostic approach and dietary control of both immune- and non-immune-mediated food-induced diseases might minimize the nutritional gaps in these patients, thus helping to improve their quality of life and reduce the economic costs of their management.
Identifiants
pubmed: 34068047
pii: nu13051638
doi: 10.3390/nu13051638
pmc: PMC8152468
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Science. 2015 Aug 28;349(6251):989-93
pubmed: 26160380
J Allergy Clin Immunol Pract. 2019 Jul - Aug;7(6):1920-1928.e11
pubmed: 30898689
Biomolecules. 2020 Aug 14;10(8):
pubmed: 32824107
Acta Biomed. 2019 Jan 29;90(3-S):80-90
pubmed: 30830065
J Allergy Clin Immunol. 2004 Jan;113(1):11-28; quiz 29
pubmed: 14713902
Allergy. 2021 May;76(5):1398-1415
pubmed: 33043467
Immunology. 2006 Jan;117(1):29-37
pubmed: 16423038
Nutrients. 2020 Aug 09;12(8):
pubmed: 32784846
Clin Nutr Res. 2014 Jan;3(1):9-16
pubmed: 24527415
Immunol Allergy Clin North Am. 2009 Feb;29(1):99-107, x
pubmed: 19141345
JAMA. 2019 Mar 12;321(10):946-955
pubmed: 30794314
Curr Opin Allergy Clin Immunol. 2021 Apr 1;21(2):195-201
pubmed: 33394703
Pediatr Allergy Immunol. 1993 May;4(2):53-9
pubmed: 8353646
Public Health Nutr. 2021 Feb;24(3):531-535
pubmed: 32924902
Nature. 2020 Dec;588(7837):303-307
pubmed: 33239790
J Pediatr (Rio J). 2014 Jan-Feb;90(1):16-21
pubmed: 24131740
Ann Dermatol. 2011 Sep;23 Suppl 1:S91-5
pubmed: 22028584
Ann Allergy Asthma Immunol. 2018 Jul;121(1):69-76.e2
pubmed: 29709643
Ann Allergy Asthma Immunol. 2015 Apr;114(4):319-26
pubmed: 25841330
Gastroenterology. 2001 Mar;120(4):1026-40
pubmed: 11231958
Ital J Pediatr. 2012 Sep 14;38:43
pubmed: 22980517
JAMA Netw Open. 2019 Jan 4;2(1):e185630
pubmed: 30646188
Proc Natl Acad Sci U S A. 2014 Sep 9;111(36):13145-50
pubmed: 25157157
J Allergy Clin Immunol. 2020 Jun;145(6):1517-1528
pubmed: 32507229
Ann Allergy. 1987 Jan;58(1):14-27
pubmed: 3099610
Curr Opin Allergy Clin Immunol. 2013 Jun;13(3):275-9
pubmed: 23510952
Curr Allergy Asthma Rep. 2007 Sep;7(5):363-7
pubmed: 17697645
J Allergy Clin Immunol. 2011 Mar;127(3):647-53.e1-3
pubmed: 21377033
Allergy Asthma Clin Immunol. 2011 Nov 10;7 Suppl 1:S7
pubmed: 22166142
BMC Med. 2014 May 23;12:85
pubmed: 24885375
J Hum Nutr Diet. 2018 Apr;31(2):239-255
pubmed: 29336079
Acta Paediatr Scand. 1991 Nov;80(11):1092-3
pubmed: 1750344
Allergy. 2016 Nov;71(11):1552-1560
pubmed: 27015954
Allergy. 2014 May;69(5):590-601
pubmed: 24697491
J Allergy Clin Immunol Pract. 2020 Jan;8(1):91-101
pubmed: 31474543
Clin Rev Allergy Immunol. 2019 Oct;57(2):272-285
pubmed: 30903439
Eur Ann Allergy Clin Immunol. 2009 Aug;41(4):106-11
pubmed: 19877562
J Allergy Clin Immunol. 2017 Apr;139(4):1099-1110
pubmed: 28257972
J Allergy Clin Immunol. 2015 Jul;136(1):59-68.e14
pubmed: 25617223
Allergy. 2020 Sep;75(9):2185-2205
pubmed: 32249942
Clin Transl Allergy. 2015 Oct 13;5:34
pubmed: 26468368
Pediatr Allergy Immunol. 2008 Jun;19(4):348-54
pubmed: 18167160
Nutrients. 2020 Jan 04;12(1):
pubmed: 31947991
Science. 2018 Dec 14;362(6420):1306-1309
pubmed: 30545888
Am J Clin Nutr. 1996 Aug;64(2):232-6
pubmed: 8694025
World J Gastroenterol. 2012 Aug 28;18(32):4379-85
pubmed: 22969202
Pediatr Ann. 2013 Jul;42(7):135-40
pubmed: 23805961
Curr Gastroenterol Rep. 2015 Sep;17(9):33
pubmed: 26205715
Front Immunol. 2018 Dec 12;9:2939
pubmed: 30619299
Nutrition. 2017 Jan;33:322-325
pubmed: 27727008
Clin Gastroenterol Hepatol. 2014 Aug;12(8):1272-9
pubmed: 24440337
Dermatol Ther. 2006 Mar-Apr;19(2):97-103
pubmed: 16669992
Nutr J. 2013 Dec 13;12:160
pubmed: 24330605
Nutrients. 2020 Nov 01;12(11):
pubmed: 33139629
Clin Exp Allergy. 2004 Sep;34(9):1336-41
pubmed: 15347364
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:73-77
pubmed: 28244660
Minerva Pediatr. 2008 Dec;60(6):1401-9
pubmed: 18971901
J Allergy Clin Immunol Pract. 2018 Sep - Oct;6(5):1483-1495
pubmed: 30201096
World J Gastroenterol. 2017 Dec 21;23(47):8321-8333
pubmed: 29307992
J Allergy Clin Immunol. 2015 Jan;135(1):179-86
pubmed: 25567046
J Allergy Clin Immunol. 2016 Nov;138(5):1253-1264
pubmed: 27817797
Immunol Allergy Clin North Am. 2012 Feb;32(1):165-95
pubmed: 22244239
Nutrients. 2020 Dec 10;12(12):
pubmed: 33321805
Nutrients. 2019 Dec 12;11(12):
pubmed: 31842421
BMJ. 2015 Feb 25;350:h701
pubmed: 25716701
Clin Exp Immunol. 2005 Jun;140(3):408-16
pubmed: 15932501
J Allergy Clin Immunol Pract. 2019 Feb;7(2):670-672
pubmed: 30075344
Ann Intern Med. 2010 Jun 15;152(12):797-803
pubmed: 20404262
J Pediatr Gastroenterol Nutr. 2009 Jan;48(1):30-6
pubmed: 19172120
J Allergy Clin Immunol. 2010 Dec;126(6 Suppl):S1-58
pubmed: 21134576
Pediatrics. 1998 Mar;101(3):E8
pubmed: 9481027
J Psychosom Res. 1999 Dec;47(6):545-54
pubmed: 10661602
J Allergy Clin Immunol. 2016 Apr;137(4):1216-1225.e5
pubmed: 26560039
Dermatitis. 2015 Mar-Apr;26(2):78-88
pubmed: 25757079
Nutr J. 2015 Aug 21;14:83
pubmed: 26293684
J Allergy Clin Immunol. 1997 Jun;99(6 Pt 1):744-51
pubmed: 9215240
Gastroenterology. 2017 Jan;152(1):124-133.e2
pubmed: 27746233
Immunity. 2019 Feb 19;50(2):285-287
pubmed: 30784576
Gastroenterology. 2013 Aug;145(2):320-8.e1-3
pubmed: 23648697
Nature. 2013 Dec 19;504(7480):451-5
pubmed: 24226773
Nat Commun. 2017 Sep 21;8(1):641
pubmed: 28935935
J Allergy Clin Immunol. 2007 Jan;119(1):213-8
pubmed: 17208604
J Allergy Clin Immunol. 1992 Aug;90(2):256-62
pubmed: 1500630
Ann Allergy Asthma Immunol. 2002 Dec;89(6 Suppl 1):97-101
pubmed: 12487214
J Allergy Clin Immunol. 2010 Dec;126(6):1105-18
pubmed: 21134568
Allergy. 2001;56 Suppl 67:98-101
pubmed: 11298021
Gastroenterol Clin North Am. 2014 Jun;43(2):297-316
pubmed: 24813517
Mediators Inflamm. 2019 Jan 16;2019:9062537
pubmed: 30800003
Gastroenterology. 2020 Jan;158(1):111-122.e10
pubmed: 31593702
Allergy. 2014 Aug;69(8):992-1007
pubmed: 24816523
J Allergy Clin Immunol Pract. 2013 Jul-Aug;1(4):332-40; quiz 341-2
pubmed: 24565538
Am J Gastroenterol. 2003 Apr;98(4):777-82
pubmed: 12738455
J Psychosom Res. 2021 Feb;141:110344
pubmed: 33383523
Clin Gastroenterol Hepatol. 2018 Jun;16(6):823-836.e2
pubmed: 29551598
Pediatr Allergy Immunol. 2004 Dec;15(6):566-9
pubmed: 15610373
Clin Gastroenterol Hepatol. 2005 Dec;3(12):1198-206
pubmed: 16361045
J Allergy Clin Immunol. 2008 Apr;121(4):853-9.e4
pubmed: 18279945
Clin Gastroenterol Hepatol. 2013 Oct;11(10):1294-1299.e1
pubmed: 23639603
Clin Rev Allergy Immunol. 2014 Jun;46(3):225-40
pubmed: 23229594
Nutrients. 2015 Sep 18;7(9):8020-35
pubmed: 26393648
Science. 2014 Mar 28;343(6178):1249288
pubmed: 24625929
Calcif Tissue Int. 2016 Jan;98(1):1-17
pubmed: 26445771
Immunity. 2016 Jul 19;45(1):198-208
pubmed: 27421705
J Immunol. 2014 Dec 15;193(12):5801-8
pubmed: 25385824
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:8-10
pubmed: 28244669
Curr Allergy Asthma Rep. 2020 Feb 14;20(2):6
pubmed: 32067114
Clin Exp Allergy. 2017 Oct;47(10):1232-1238
pubmed: 28779526
J Immunol. 2002 Mar 1;168(5):2464-9
pubmed: 11859139
Hum Pathol. 1993 Jun;24(6):668-74
pubmed: 8505043
J Allergy Clin Immunol. 2018 Jan;141(1):41-58
pubmed: 29157945
J Allergy Clin Immunol Pract. 2013 Jan;1(1):22-8
pubmed: 24229818
Curr Opin Allergy Clin Immunol. 2005 Jun;5(3):275-9
pubmed: 15864088
N Engl J Med. 2014 Jul 10;371(2):130-9
pubmed: 25006719
Pediatr Allergy Immunol. 2021 Feb;32(2):223-233
pubmed: 33020989
Prehosp Emerg Care. 2017 Jan-Feb;21(1):83-85
pubmed: 27436170
Aliment Pharmacol Ther. 2005 Feb 15;21(4):421-9
pubmed: 15709993
Clin Gastroenterol Hepatol. 2008 May;6(5):598-600
pubmed: 18407800
Gastroenterology. 2018 Feb;154(3):529-539.e2
pubmed: 29102613
J Pediatr. 2002 Feb;140(2):219-24
pubmed: 11865274
J Allergy Clin Immunol. 2013 Feb;131(2):590-2.e1-6
pubmed: 23083674
Dig Dis Sci. 2017 Sep;62(9):2408-2420
pubmed: 28608048
J Allergy Clin Immunol. 2014 Sep;134(3):645-52
pubmed: 25065721
Acta Paediatr. 2005 Oct;94(10):1514-5
pubmed: 16263634
Gastroenterology. 2014 Jan;146(1):67-75.e5
pubmed: 24076059
Allergy. 2003 Jan;58(1):88-9
pubmed: 12580819
Int Arch Allergy Immunol. 2009;150(3):271-7
pubmed: 19494524
J Investig Allergol Clin Immunol. 2015;25(6):440-1
pubmed: 26817142
Clin Rev Allergy Immunol. 2016 Apr;50(2):175-88
pubmed: 26054822
Ann Allergy Asthma Immunol. 2018 Dec;121(6):736-738
pubmed: 30121366
Allergy Asthma Proc. 1996 Jul-Aug;17(4):215-9
pubmed: 8871741
Pediatrics. 2003 Apr;111(4 Pt 1):829-35
pubmed: 12671120
Neonatology. 2019;116(4):376-379
pubmed: 31553974
Science. 2016 Mar 18;351(6279):1296-302
pubmed: 26989247
Eur J Clin Nutr. 2005 Oct;59(10):1105-11
pubmed: 16015262
World J Gastroenterol. 2007 Jul 7;13(25):3430-7
pubmed: 17659689
Cell Rep. 2016 Jun 21;15(12):2809-24
pubmed: 27332875
Nat Immunol. 2011 Dec 04;13(1):58-66
pubmed: 22138715
Nutrients. 2020 Aug 07;12(8):
pubmed: 32784614
Allergy. 2011 Jan;66(1):92-100
pubmed: 20608919
J Allergy Clin Immunol. 2014 May;133(5):1270-7
pubmed: 24766875
Gastroenterol Clin North Am. 2019 Mar;48(1):165-182
pubmed: 30711208
Allergy. 2014 Aug;69(8):1008-25
pubmed: 24909706
Nutrients. 2013 Sep 26;5(10):3839-53
pubmed: 24077239
Clin Gastroenterol Hepatol. 2017 Mar;15(3):339-348
pubmed: 27523634
J Allergy Clin Immunol. 2012 Feb;129(2):580-2, 582.e1-5
pubmed: 22078573
J Allergy Clin Immunol. 2014 Aug;134(2):382-9
pubmed: 24880634
Allergy. 2012 Oct;67(10):1299-307
pubmed: 22913672
Eur Ann Allergy Clin Immunol. 2006 Apr;38(4):118-21
pubmed: 16805416
Clin Exp Allergy. 2009 Aug;39(8):1234-45
pubmed: 19549026
J Investig Allergol Clin Immunol. 2007;17(3):189-91
pubmed: 17583107
J Allergy Clin Immunol. 2016 Sep;138(3):654-665
pubmed: 27596706
Eur J Clin Nutr. 2006 May;60(5):667-72
pubmed: 16391571
J Allergy Clin Immunol. 2014 Mar;133(3):621-31
pubmed: 24581429
Nutrients. 2019 Sep 09;11(9):
pubmed: 31505870
J Exp Med. 2012 Feb 13;209(2):353-64
pubmed: 22249450
World J Gastroenterol. 2020 May 28;26(20):2632-2644
pubmed: 32523316
Digestion. 2016;94(1):50-6
pubmed: 27487397
J Allergy Clin Immunol Pract. 2014 May-Jun;2(3):355-7.e1
pubmed: 24811033
Eur J Clin Nutr. 2005 Apr;59(4):489-93
pubmed: 15674309
Am J Gastroenterol. 2006 Mar;101(3):596-603
pubmed: 16464229
J Allergy Clin Immunol. 2010 May;125(5):1077-1083.e8
pubmed: 20451041
J Nutr. 2012 Aug;142(8):1510-8
pubmed: 22739368
J Allergy Clin Immunol. 2019 Jan;143(1):46-55
pubmed: 30458183
Gastroenterology. 2018 Jan;154(2):319-332.e3
pubmed: 28774845
Gastroenterology. 2021 Jan;160(1):63-75
pubmed: 32950520
Clin Gastroenterol Hepatol. 2021 Jan 22;:
pubmed: 33493695
Neurogastroenterol Motil. 2016 Apr;28(4):581-91
pubmed: 26867677
J Gastroenterol Hepatol. 2017 Mar;32 Suppl 1:11-15
pubmed: 28244664
Allergo J Int. 2017;26(2):72-79
pubmed: 28344921
Ann Emerg Med. 2006 Apr;47(4):373-80
pubmed: 16546624
Curr Opin Allergy Clin Immunol. 2016 Aug;16(4):390-5
pubmed: 27253486
J Pediatr Gastroenterol Nutr. 2019 Feb;68(2):232-236
pubmed: 30320669
World J Gastroenterol. 2014 Oct 21;20(39):14407-19
pubmed: 25339827
N Engl J Med. 2018 Nov 22;379(21):1991-2001
pubmed: 30449234
Eur Ann Allergy Clin Immunol. 2006 Feb;38(2):45-51
pubmed: 16711535
Allergy. 2021 Jan;76(1):90-113
pubmed: 32593226
Curr Opin Allergy Clin Immunol. 2017 Oct;17(5):350-355
pubmed: 28742538
Clin Exp Allergy. 2012 Aug;42(8):1257-65
pubmed: 22805473
Mol Immunol. 2018 Aug;100:82-106
pubmed: 29731166
Pediatr Allergy Immunol. 2010 Jul;21 Suppl 21:1-125
pubmed: 20618740
J Immunol Res. 2018 Jun 3;2018:2724951
pubmed: 29967798
J Allergy Clin Immunol Pract. 2020 Jun;8(6):1854-1864
pubmed: 32499034
Nat Rev Immunol. 2021 Mar;21(3):177-191
pubmed: 32918062
Gastroenterology. 2018 Jan;154(2):333-345
pubmed: 28757265
Nutrients. 2019 Aug 08;11(8):
pubmed: 31398959
Intest Res. 2019 Jul;17(3):427-433
pubmed: 30836736
Pediatr Clin North Am. 2015 Dec;62(6):1377-92
pubmed: 26456438
Front Nutr. 2020 May 29;7:73
pubmed: 32548124
Crit Rev Food Sci Nutr. 2019;59(11):1675-1683
pubmed: 29425071
J Pediatr Gastroenterol Nutr. 2000;30 Suppl:S28-35
pubmed: 10634296
J Food Sci. 2020 Mar;85(3):843-852
pubmed: 32090335
Immunity. 2019 May 21;50(5):1132-1148
pubmed: 31117010
Immunity. 2015 Aug 18;43(2):289-303
pubmed: 26231118
Nutrients. 2019 Jun 11;11(6):
pubmed: 31212668
Gut. 2019 Nov;68(11):2080-2091
pubmed: 31427404
Curr Drug Metab. 2016;17(2):187-93
pubmed: 26806042
Aliment Pharmacol Ther. 2015 Jan;41(1):3-25
pubmed: 25316115
Curr Allergy Asthma Rep. 2003 Jan;3(1):15-21
pubmed: 12542988
Minerva Pediatr. 1996 Mar;48(3):71-7
pubmed: 8766671
Scand J Gastroenterol. 2011 Jul;46(7-8):823-30
pubmed: 21561228
Gut. 2010 Jan;59(1):12-20
pubmed: 19528036
N Engl J Med. 2008 Sep 18;359(12):1252-60
pubmed: 18799559
Ann Allergy Asthma Immunol. 2004 Feb;92(2):268-72
pubmed: 14989398
Proc Natl Acad Sci U S A. 2012 May 22;109(21):8334-9
pubmed: 22566627
Gastroenterol Hepatol Bed Bench. 2012 Winter;5(1):16-23
pubmed: 24834193
Nature. 2014 Jul 10;511(7508):184-90
pubmed: 24930766
Gut. 2015 Jan;64(1):93-100
pubmed: 25016597
Immunity. 2020 Aug 18;53(2):277-289
pubmed: 32814026
Clin Exp Rheumatol. 2012 Nov-Dec;30(6 Suppl 74):10-7
pubmed: 22766026
J Allergy Clin Immunol. 2018 Sep;142(3):857-864.e3
pubmed: 29154959
Sci Rep. 2016 Jan 20;6:19685
pubmed: 26785945
Nutrients. 2020 Jul 14;12(7):
pubmed: 32674427
Am J Gastroenterol. 2013 Sep;108(9):1516-25
pubmed: 23917444
Allergol Immunopathol (Madr). 2016 Sep-Oct;44(5):475-83
pubmed: 27590961
Allergy. 2020 Sep;75(9):2158-2160
pubmed: 32738058
Gastroenterology. 2014 Sep;147(3):602-9
pubmed: 24907494
J Allergy Clin Immunol Pract. 2019 Sep - Oct;7(7):2348-2358.e4
pubmed: 30940532
Clin Exp Allergy. 2010 Apr;40(4):637-42
pubmed: 20067480
Nutrients. 2017 Nov 21;9(11):
pubmed: 29160841
J Allergy Clin Immunol. 2004 May;113(5):805-19; quiz 820
pubmed: 15131561
World Allergy Organ J. 2020 Oct 30;13(10):100472
pubmed: 33204386
Psychol Health Med. 2018 Jul;23(6):674-684
pubmed: 29260889
Gen Hosp Psychiatry. 2010 Jan-Feb;32(1):42-8
pubmed: 20114127
Am J Gastroenterol. 2014 Jan;109(1):110-9
pubmed: 24247211
Pediatr Allergy Immunol. 2014 Nov;25(7):651-6
pubmed: 25283440
J Allergy Clin Immunol. 2013 Apr;131(4):1204-12
pubmed: 23453135
Clin Gastroenterol Hepatol. 2017 Jan;15(1):63-68.e2
pubmed: 27552857
Proc Natl Acad Sci U S A. 2017 Jan 17;114(3):E367-E375
pubmed: 28049818
PLoS Med. 2018 Feb 28;15(2):e1002507
pubmed: 29489823
Clin Exp Allergy. 2013 Dec;43(12):1374-83
pubmed: 24261947
J Allergy Clin Immunol. 2012 Dec;130(6):1260-74
pubmed: 23195525
Pediatr Allergy Immunol. 2010 Jun;21(4 Pt 1):577-85
pubmed: 20337976
BMJ Nutr Prev Health. 2019 Mar 19;2(1):39-42
pubmed: 33235956
Allergy. 2019 May;74(5):976-985
pubmed: 30485456
Nutrients. 2015 Jun 18;7(6):4966-77
pubmed: 26096570
J Immunol. 2016 Aug 15;197(4):1335-42
pubmed: 27421480
Gut. 2017 Jul;66(7):1241-1251
pubmed: 26976734
J Allergy Clin Immunol. 2012 Nov;130(5):1199-200
pubmed: 22835404
Pediatr Allergy Immunol. 2016 May;27(3):276-82
pubmed: 26764899
J Allergy Clin Immunol. 2020 Jun;145(6):1485-1497
pubmed: 32507227
World Allergy Organ J. 2011 Feb;4(2):13-37
pubmed: 23268454
Nature. 2018 Mar 8;555(7695):210-215
pubmed: 29489753
Dig Dis Sci. 2018 Jul;63(7):1756-1762
pubmed: 29611076
Science. 2019 Aug 30;365(6456):
pubmed: 31371561