Role of Carbonic Anhydrase in Cerebral Ischemia and Carbonic Anhydrase Inhibitors as Putative Protective Agents.
Bicarbonates
/ metabolism
Brain
/ metabolism
Brain Ischemia
/ drug therapy
Carbon Dioxide
/ metabolism
Carbonic Anhydrase Inhibitors
/ therapeutic use
Carbonic Anhydrases
/ genetics
Humans
Infarction, Middle Cerebral Artery
/ drug therapy
Ischemic Stroke
/ drug therapy
Sulfonamides
/ therapeutic use
carbonic anhydrase
cerebral ischemia
inhibitors
ischemic acidosis
middle cerebral artery occlusion
sulfonamide
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
10 May 2021
10 May 2021
Historique:
received:
28
04
2021
revised:
07
05
2021
accepted:
07
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
16
6
2021
Statut:
epublish
Résumé
Ischemic stroke is a leading cause of death and disability worldwide. The only pharmacological treatment available to date for cerebral ischemia is tissue plasminogen activator (t-PA) and the search for successful therapeutic strategies still remains a major challenge. The loss of cerebral blood flow leads to reduced oxygen and glucose supply and a subsequent switch to the glycolytic pathway, which leads to tissue acidification. Carbonic anhydrase (CA, EC 4.2.1.1) is the enzyme responsible for converting carbon dioxide into a protons and bicarbonate, thus contributing to pH regulation and metabolism, with many CA isoforms present in the brain. Recently, numerous studies have shed light on several classes of carbonic anhydrase inhibitor (CAI) as possible new pharmacological agents for the management of brain ischemia. In the present review we summarized pharmacological, preclinical and clinical findings regarding the role of CAIs in strokes and we discuss their potential protective mechanisms.
Identifiants
pubmed: 34068564
pii: ijms22095029
doi: 10.3390/ijms22095029
pmc: PMC8126098
pii:
doi:
Substances chimiques
Bicarbonates
0
Carbonic Anhydrase Inhibitors
0
Sulfonamides
0
Carbon Dioxide
142M471B3J
Carbonic Anhydrases
EC 4.2.1.1
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministero dell'Istruzione, dell'Università e della Ricerca
ID : 2017XYBP2R
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