Inhibition of Lysine 63 Ubiquitination Prevents the Progression of Renal Fibrosis in Diabetic DBA/2J Mice.
Angiotensin-Converting Enzyme Inhibitors
/ pharmacology
Animals
Diabetes Mellitus, Experimental
/ complications
Diabetic Nephropathies
/ etiology
Drug Therapy, Combination
Female
Fibrosis
/ etiology
Lysine
/ chemistry
Mice
Mice, Inbred DBA
Nitrofurans
/ pharmacology
Ramipril
/ pharmacology
Sulfones
/ pharmacology
Ubiquitination
DBA2/J mice
diabetes
lysine 63 ubiquitination
microRNA
renal fibrosis
senescence
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
14 May 2021
14 May 2021
Historique:
received:
06
05
2021
accepted:
12
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
11
6
2021
Statut:
epublish
Résumé
Diabetic nephropathy (DN) is the most frequent cause of end-stage renal disease. Tubulointerstitial accumulation of lysine 63 (K63)-ubiquitinated (Ub) proteins is involved in the progression of DN fibrosis and correlates with urinary miR-27b-3p downregulation. We explored the renoprotective effect of an inhibitor of K63-Ub (NSC697923), alone or in combination with the ACE-inhibitor ramipril, in vitro and in vivo. Proximal tubular epithelial cells and diabetic DBA/2J mice were treated with NSC697923 and/or ramipril. K63-Ub protein accumulation along with α-SMA, collagen I and III, FSP-1, vimentin, p16
Identifiants
pubmed: 34068941
pii: ijms22105194
doi: 10.3390/ijms22105194
pmc: PMC8157080
pii:
doi:
Substances chimiques
2-((4-methylphenyl)sulfonyl)-5-nitrofuran
0
Angiotensin-Converting Enzyme Inhibitors
0
Nitrofurans
0
Sulfones
0
Lysine
K3Z4F929H6
Ramipril
L35JN3I7SJ
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Innovative Medicines Initiative
ID : grant agreement No 115974
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