Sexual Dimorphism of Corticosteroid Signaling during Kidney Development.
Adrenal Cortex Hormones
/ metabolism
Aldosterone
/ metabolism
Animals
Blood Pressure
/ physiology
Gene Expression Regulation, Developmental
/ genetics
Glucocorticoids
/ metabolism
Humans
Hypertension
/ metabolism
Kidney
/ embryology
Mineralocorticoids
/ metabolism
Organogenesis
Receptors, Glucocorticoid
/ metabolism
Receptors, Mineralocorticoid
/ metabolism
Sex Characteristics
Signal Transduction
/ physiology
aldosterone
cortisol
development
kidney
mineralocorticoid and glucocorticoid receptors
neonates
sexual dimorphism
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 May 2021
18 May 2021
Historique:
received:
17
04
2021
revised:
07
05
2021
accepted:
10
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
24
6
2021
Statut:
epublish
Résumé
Sexual dimorphism involves differences between biological sexes that go beyond sexual characteristics. In mammals, differences between sexes have been demonstrated regarding various biological processes, including blood pressure and predisposition to develop hypertension early in adulthood, which may rely on early events during development and in the neonatal period. Recent studies suggest that corticosteroid signaling pathways (comprising glucocorticoid and mineralocorticoid signaling pathways) have distinct tissue-specific expression and regulation during this specific temporal window in a sex-dependent manner, most notably in the kidney. This review outlines the evidence for a gender differential expression and activation of renal corticosteroid signaling pathways in the mammalian fetus and neonate, from mouse to human, that may favor mineralocorticoid signaling in females and glucocorticoid signaling in males. Determining the effects of such differences may shed light on short term and long term pathophysiological consequences, markedly for males.
Identifiants
pubmed: 34069759
pii: ijms22105275
doi: 10.3390/ijms22105275
pmc: PMC8155845
pii:
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Glucocorticoids
0
Mineralocorticoids
0
Receptors, Glucocorticoid
0
Receptors, Mineralocorticoid
0
Aldosterone
4964P6T9RB
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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