Implications of SGLT Inhibition on Redox Signalling in Atrial Fibrillation.
Animals
Atrial Fibrillation
/ drug therapy
Calcium
/ metabolism
Cells, Cultured
Humans
Myocytes, Cardiac
/ drug effects
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Reactive Oxygen Species
/ metabolism
Sodium-Glucose Transporter 1
/ antagonists & inhibitors
Sodium-Glucose Transporter 2 Inhibitors
/ pharmacology
Ca2+ homeostasis
SGLT inhibition
atrial fibrillation
cardiomyocytes
heart failure
mitochondrial function
oxidative stress
reactive oxygen species
redox signalling
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
31 May 2021
31 May 2021
Historique:
received:
26
04
2021
revised:
25
05
2021
accepted:
26
05
2021
entrez:
2
6
2021
pubmed:
3
6
2021
medline:
8
7
2021
Statut:
epublish
Résumé
Atrial fibrillation (AF) is the most common sustained (atrial) arrhythmia, a considerable global health burden and often associated with heart failure. Perturbations of redox signalling in cardiomyocytes provide a cellular substrate for the manifestation and maintenance of atrial arrhythmias. Several clinical trials have shown that treatment with sodium-glucose linked transporter inhibitors (SGLTi) improves mortality and hospitalisation in heart failure patients independent of the presence of diabetes. Post hoc analysis of the DECLARE-TIMI 58 trial showed a 19% reduction in AF in patients with diabetes mellitus (hazard ratio, 0.81 (95% confidence interval: 0.68-0.95), n = 17.160) upon treatment with SGLTi, regardless of pre-existing AF or heart failure and independent from blood pressure or renal function. Accordingly, ongoing experimental work suggests that SGLTi not only positively impact heart failure but also counteract cellular ROS production in cardiomyocytes, thereby potentially altering atrial remodelling and reducing AF burden. In this article, we review recent studies investigating the effect of SGLTi on cellular processes closely interlinked with redox balance and their potential effects on the onset and progression of AF. Despite promising insight into SGLTi effect on Ca
Identifiants
pubmed: 34073033
pii: ijms22115937
doi: 10.3390/ijms22115937
pmc: PMC8198069
pii:
doi:
Substances chimiques
Reactive Oxygen Species
0
SLC5A1 protein, human
0
Sodium-Glucose Transporter 1
0
Sodium-Glucose Transporter 2 Inhibitors
0
Calcium
SY7Q814VUP
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Cardiovasc Diabetol. 2017 Sep 29;16(1):120
pubmed: 28962617
J Am Coll Cardiol. 2008 Feb 5;51(5):585-94
pubmed: 18237690
J Electrocardiol. 2016 May-Jun;49(3):423-8
pubmed: 27034122
ESC Heart Fail. 2018 Aug;5(4):642-648
pubmed: 30117720
Cardiovasc Diabetol. 2017 Mar 3;16(1):32
pubmed: 28253918
J Am Coll Cardiol. 2013 Oct 15;62(16):1466-73
pubmed: 23644086
Circ Res. 1997 Jan;80(1):82-7
pubmed: 8978326
J Am Heart Assoc. 2019 Dec 17;8(24):e011560
pubmed: 31818219
Circ Res. 2014 Apr 25;114(9):1483-99
pubmed: 24763466
Circulation. 2010 Apr 13;121(14):1606-13
pubmed: 20351235
Biophys J. 2003 Apr;84(4):2734-55
pubmed: 12668482
Int J Cardiol. 2017 Sep 15;243:86-90
pubmed: 28526540
Int J Cardiol. 2005 Dec 7;105(3):315-8
pubmed: 16274775
J Am Heart Assoc. 2015 Aug 27;4(9):e002183
pubmed: 26316524
Sci Rep. 2015 Jul 14;5:11427
pubmed: 26169582
Biochim Biophys Acta. 2007 Oct;1768(10):2510-5
pubmed: 17617374
J Am Coll Cardiol. 2010 May 25;55(21):2330-42
pubmed: 20488304
J Pharmacol Exp Ther. 2006 Jul;318(1):214-22
pubmed: 16565163
Circ Res. 2008 Dec 5;103(12):1466-72
pubmed: 19008475
Front Cardiovasc Med. 2020 Apr 29;7:62
pubmed: 32411723
Am J Physiol Heart Circ Physiol. 2016 Jul 1;311(1):H54-63
pubmed: 27199126
Circ Res. 2012 Sep 28;111(8):1091-106
pubmed: 23023511
Circulation. 2020 Apr 14;141(15):1227-1234
pubmed: 31983236
Science. 2011 Sep 9;333(6048):1440-5
pubmed: 21903813
Am J Physiol. 1999 Jun;276(6):H2168-78
pubmed: 10362701
N Engl J Med. 2020 Oct 8;383(15):1413-1424
pubmed: 32865377
J Physiol. 2014 Mar 1;592(5):829-39
pubmed: 24366263
Basic Res Cardiol. 2020 Nov 30;115(6):72
pubmed: 33258071
Free Radic Biol Med. 2017 Mar;104:298-310
pubmed: 28132924
Nat Med. 2004 Nov;10(11):1200-7
pubmed: 15489859
J Am Heart Assoc. 2017 Oct 31;6(11):
pubmed: 29089343
Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H921-35
pubmed: 21666112
Heart. 2019 Dec;105(24):1860-1867
pubmed: 31444267
Circ Arrhythm Electrophysiol. 2018 Jul;11(7):e006350
pubmed: 30002066
Circ Arrhythm Electrophysiol. 2012 Aug 1;5(4):860-7
pubmed: 22895602
Circulation. 2012 May 1;125(17):2059-70
pubmed: 22456474
Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):865-77
pubmed: 20175987
JAMA. 1994 Mar 16;271(11):840-4
pubmed: 8114238
Nature. 2011 Jun 19;476(7360):336-40
pubmed: 21685888
J Interv Card Electrophysiol. 2008 Aug;22(2):111-8
pubmed: 18264747
Heart Rhythm. 2020 Aug;17(8):1398-1404
pubmed: 32268208
Cardiovasc Diabetol. 2020 Sep 30;19(1):159
pubmed: 32998746
Int J Mol Sci. 2020 Nov 16;21(22):
pubmed: 33207633
Pharmacol Res. 2020 Aug;158:104870
pubmed: 32434052
Biochem J. 2004 Jan 15;377(Pt 2):357-66
pubmed: 14556649
Int J Cardiol. 2017 Sep 15;243:258-262
pubmed: 28747027
Drug Discov Today Dis Mech. 2010 Summer;7(2):e117-e122
pubmed: 21503275
J Biol Chem. 2006 Oct 27;281(43):32207-16
pubmed: 16943194
Cardiovasc Diabetol. 2021 Jan 7;20(1):7
pubmed: 33413413
Circ Res. 2018 May 11;122(10):1460-1478
pubmed: 29748369
J Mol Cell Cardiol. 2015 Aug;85:240-8
pubmed: 26092277
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41
pubmed: 20018762
Cardiovasc Res. 2006 Jul 15;71(2):310-21
pubmed: 16581043
Diabetologia. 2018 Mar;61(3):722-726
pubmed: 29197997
Circulation. 2020 Apr 14;141(15):1235-1237
pubmed: 32282249
Nat Rev Mol Cell Biol. 2018 Nov;19(11):713-730
pubmed: 30143745
Cardiovasc Res. 2020 Nov 02;:
pubmed: 33135077
J Clin Invest. 2021 Jan 19;131(2):
pubmed: 33151911
Circulation. 2013 Oct 15;128(16):1748-57
pubmed: 24030498
Biochem J. 1998 Aug 15;334 ( Pt 1):177-87
pubmed: 9693118
Cardiovasc Diabetol. 2019 Apr 5;18(1):46
pubmed: 30953516
J Cell Biol. 2005 Nov 7;171(3):537-47
pubmed: 16275756
Curr Pharm Des. 2018;24(26):3055-3061
pubmed: 30179127
Biophys J. 2002 Aug;83(2):587-604
pubmed: 12124250
Circ Res. 2017 Apr 28;120(9):1501-1517
pubmed: 28450367
Front Pharmacol. 2014 Mar 04;5:30
pubmed: 24624086
Hypertension. 2010 Apr;55(4):918-23
pubmed: 20194307
Redox Biol. 2015 Dec;6:565-577
pubmed: 26496488
JACC Clin Electrophysiol. 2019 Aug;5(8):897-903
pubmed: 31439289
Europace. 2014 Aug;16(8):1107-16
pubmed: 24706090
Life Sci. 2007 Apr 17;80(19):1806-15
pubmed: 17383682
Circulation. 2011 Sep 6;124(10):1107-17
pubmed: 21844076
Eur Heart J. 2016 May 21;37(20):1565-72
pubmed: 26371114
Cell Rep. 2017 Oct 3;21(1):1-9
pubmed: 28978464
Free Radic Biol Med. 2012 Dec 15;53(12):2263-8
pubmed: 23085513
Am J Physiol Heart Circ Physiol. 2013 Apr 1;304(7):H983-93
pubmed: 23376829
Acta Physiol (Oxf). 2020 Mar;228(3):e13415
pubmed: 31729810
J Mol Cell Cardiol. 2011 Oct;51(4):468-73
pubmed: 21276796
Can J Cardiol. 2020 Apr;36(4):543-553
pubmed: 31837891
Physiol Rev. 2010 Jan;90(1):207-58
pubmed: 20086077
Diabetologia. 2017 Mar;60(3):568-573
pubmed: 27752710
Int J Mol Sci. 2021 Jan 15;22(2):
pubmed: 33467546
J Mol Cell Cardiol. 2019 Feb;127:246-259
pubmed: 30633874
Cardiovasc Res. 2006 Jul 15;71(2):208-15
pubmed: 16631149
J Am Coll Cardiol. 2015 Jul 7;66(1):47-58
pubmed: 26139058
J Arrhythm. 2018 Jun 04;34(4):394-401
pubmed: 30167010
Mol Cell Biochem. 1990 Dec 20;99(2):83-8
pubmed: 1962847
J Cardiovasc Transl Res. 2020 Aug 25;:
pubmed: 32844365
Diabetes Metab. 2018 Dec;44(6):457-464
pubmed: 30266577
Diabetes Obes Metab. 2018 Nov;20(11):2515-2522
pubmed: 30073768
J Am Heart Assoc. 2015 Mar 15;4(3):e001733
pubmed: 25773299
Antioxid Redox Signal. 2019 Jan 20;30(3):375-398
pubmed: 29073779
Am J Physiol Heart Circ Physiol. 2007 Aug;293(2):H1231-41
pubmed: 17434983
Redox Biol. 2016 Oct;9:77-89
pubmed: 27423013
Cardiovasc Drugs Ther. 2017 Apr;31(2):119-132
pubmed: 28447181
Circulation. 2003 Apr 8;107(13):1810-5
pubmed: 12665494
Circ Res. 2005 May 13;96(9):1022-9
pubmed: 15817885
Diabetes. 2016 Sep;65(9):2784-94
pubmed: 27381369
Nat Commun. 2020 May 1;11(1):2127
pubmed: 32358544
Adipocyte. 2018;7(2):121-128
pubmed: 29376471
BMJ. 2009 Aug 21;339:b3174
pubmed: 19700509
Heart Rhythm. 2011 Jul;8(7):1101-4
pubmed: 21255680
Int J Mol Sci. 2019 Apr 04;20(7):
pubmed: 30987285
Cardiol Ther. 2020 Jun;9(1):45-58
pubmed: 31898209
J Mol Cell Cardiol. 2007 Jan;42(1):196-205
pubmed: 17052727
Cardiovasc Diabetol. 2019 Feb 2;18(1):15
pubmed: 30710997
Free Radic Biol Med. 1997;22(1-2):37-47
pubmed: 8958128
Annu Rev Physiol. 2014;76:107-27
pubmed: 24245942
Cardiovasc Diabetol. 2018 Nov 17;17(1):144
pubmed: 30447687
J Am Coll Cardiol. 2018 May 22;71(20):2360-2372
pubmed: 29773163
Nature. 1989 Nov 2;342(6245):90-2
pubmed: 2530454
Cardiovasc Diabetol. 2019 Nov 28;18(1):165
pubmed: 31779619
N Engl J Med. 2019 Nov 21;381(21):1995-2008
pubmed: 31535829
Physiol Rev. 1990 Apr;70(2):391-425
pubmed: 2157230
Mol Cell Endocrinol. 2020 Feb 5;501:110642
pubmed: 31759100
Stroke. 1991 Aug;22(8):983-8
pubmed: 1866765
J Am Heart Assoc. 2021 Jan 19;10(2):e017483
pubmed: 33399004
Eur Heart J. 2010 Oct;31(19):2369-429
pubmed: 20802247
Cell Calcium. 2014 Jan;55(1):17-23
pubmed: 24290743
J Biol Chem. 2009 Dec 18;284(51):35839-49
pubmed: 19828446
J Physiol. 1997 Apr 1;500 ( Pt 1):85-94
pubmed: 9097935
Curr Cardiol Rev. 2017;13(3):199-208
pubmed: 28124593
J Mol Cell Cardiol. 2019 Jun;131:53-65
pubmed: 31005484
Sci Rep. 2018 Mar 27;8(1):5276
pubmed: 29588466
Eur Heart J. 2007 Nov;28(22):2803-17
pubmed: 17897924
EBioMedicine. 2017 Jun;20:137-149
pubmed: 28579299
FEBS Lett. 1995 Dec 27;377(3):421-5
pubmed: 8549768
Basic Res Cardiol. 2007 Sep;102(5):369-92
pubmed: 17657400
Nature. 2011 Jun 19;476(7360):341-5
pubmed: 21685886
Biochem J. 2001 Aug 15;358(Pt 1):147-55
pubmed: 11485562
N Engl J Med. 1998 Sep 3;339(10):659-66
pubmed: 9725923
J Cell Biol. 2002 Nov 25;159(4):613-24
pubmed: 12438411
Circ Res. 2003 May 2;92(8):912-9
pubmed: 12676814
J Cell Mol Med. 2020 Aug;24(15):8567-8578
pubmed: 32652890
N Engl J Med. 2018 Feb 01;378(5):417-427
pubmed: 29385358
J Cardiovasc Electrophysiol. 2010 Aug 1;21(8):859-68
pubmed: 20132404
Cardiovasc Res. 2003 Mar 15;57(4):874-86
pubmed: 12650866
J Cell Biol. 2010 May 3;189(3):573-87
pubmed: 20421423
Diabetes Ther. 2017 Aug;8(4):851-861
pubmed: 28616806
J Cardiovasc Med (Hagerstown). 2014 Mar;15(3):235-53
pubmed: 23114271
Circ J. 2013;77(5):1171-9
pubmed: 23370453
J Biol Chem. 2005 Mar 11;280(10):9210-6
pubmed: 15582994
Front Cardiovasc Med. 2020 Dec 04;7:592233
pubmed: 33344518
Mol Med Rep. 2018 Apr;17(4):4933-4940
pubmed: 29393403
JACC Basic Transl Sci. 2018 Aug 26;3(5):575-587
pubmed: 30456329
Nature. 2013 Oct 17;502(7471):372-6
pubmed: 24077098
Int J Inflam. 2011;2011:514623
pubmed: 21860805
Nat Rev Cardiol. 2015 Apr;12(4):230-43
pubmed: 25622848
ESC Heart Fail. 2020 Sep 18;:
pubmed: 32946200
Circ Res. 1999 Oct 29;85(9):810-9
pubmed: 10532949
Cardiovasc Res. 2021 Jan 21;117(2):495-507
pubmed: 32396609
Cardiovasc Diabetol. 2019 Apr 1;18(1):45
pubmed: 30935417
J Biol Chem. 2010 Sep 10;285(37):28938-45
pubmed: 20643651
Antioxidants (Basel). 2020 Sep 14;9(9):
pubmed: 32937823