The role of stroke nurses in thrombolysis administration in Australia and the United Kingdom: A cross-sectional survey of current practice.


Journal

Journal of clinical nursing
ISSN: 1365-2702
Titre abrégé: J Clin Nurs
Pays: England
ID NLM: 9207302

Informations de publication

Date de publication:
Jan 2022
Historique:
revised: 27 04 2021
received: 12 01 2021
accepted: 04 05 2021
pubmed: 3 6 2021
medline: 15 12 2021
entrez: 2 6 2021
Statut: ppublish

Résumé

The role of stroke nurses in patient selection and administration of recombinant tissue plasminogen activator (rt-PA) for acute ischaemic stroke is evolving. To compare differences in stroke nurses' practices related to rt-PA administration in Australia and the United Kingdom (UK) and to examine whether these differences influence rt-PA treatment rates. A cross-sectional, self-administered questionnaire administered to a lead stroke clinician from hospitals known to provide rt-PA for acute ischaemic stroke. Chi-square tests were used to analyse between-country differences in ten pre-specified rt-PA practices. Non-parametric equality of medians test was used to assess within-country differences for likelihood of undertaking practices and association with rt-PA treatment rates. Reporting followed STROBE checklist. Response rate 68%; (Australia: 74% [n = 63/85]; UK: 65% [n = 93/144]). There were significant differences between countries for 7/10 practices. UK nurses were more likely to: request CT scan; screen patient for rt-PA suitability; gain informed consent; use telemedicine to assess, diagnose or treat; assist in the decision for rt-PA with Emergency Department physician or neurologist; and undergo training in rt-PA administration. Reported median hospital rt-PA treatment rates were 12% in the UK and 7.8% in Australia: (7.8%). In Australia, there was an association between higher treatment rates and nurses involvement in 5/10 practices; read and interpret CT scans; screen patient for rt-PA suitability; gain informed consent; assess suitability for rt-PA with neurologist/stroke physician; undergo training in rt-PA administration. There was no relationship between UK treatment rates and likelihood of a stroke nurse to undertake any of the ten rt-PA practices. Stroke nurses' active role in rt-PA administration can improve rt-PA treatment rates. Models of care that broaden stroke nurses' scope of practice to maximise rt-PA treatment rates for ischaemic stroke patients are needed. This study demonstrates that UK and Australian nurses play an important role in thrombolysis practices; however, they are underused. Formalising and extending the role of stroke nurses in rt-PA administration could potentially increase thrombolysis rates with clinical benefits for patients.

Sections du résumé

BACKGROUND BACKGROUND
The role of stroke nurses in patient selection and administration of recombinant tissue plasminogen activator (rt-PA) for acute ischaemic stroke is evolving.
OBJECTIVES OBJECTIVE
To compare differences in stroke nurses' practices related to rt-PA administration in Australia and the United Kingdom (UK) and to examine whether these differences influence rt-PA treatment rates.
METHODS METHODS
A cross-sectional, self-administered questionnaire administered to a lead stroke clinician from hospitals known to provide rt-PA for acute ischaemic stroke. Chi-square tests were used to analyse between-country differences in ten pre-specified rt-PA practices. Non-parametric equality of medians test was used to assess within-country differences for likelihood of undertaking practices and association with rt-PA treatment rates. Reporting followed STROBE checklist.
RESULTS RESULTS
Response rate 68%; (Australia: 74% [n = 63/85]; UK: 65% [n = 93/144]). There were significant differences between countries for 7/10 practices. UK nurses were more likely to: request CT scan; screen patient for rt-PA suitability; gain informed consent; use telemedicine to assess, diagnose or treat; assist in the decision for rt-PA with Emergency Department physician or neurologist; and undergo training in rt-PA administration. Reported median hospital rt-PA treatment rates were 12% in the UK and 7.8% in Australia: (7.8%). In Australia, there was an association between higher treatment rates and nurses involvement in 5/10 practices; read and interpret CT scans; screen patient for rt-PA suitability; gain informed consent; assess suitability for rt-PA with neurologist/stroke physician; undergo training in rt-PA administration. There was no relationship between UK treatment rates and likelihood of a stroke nurse to undertake any of the ten rt-PA practices.
CONCLUSION CONCLUSIONS
Stroke nurses' active role in rt-PA administration can improve rt-PA treatment rates. Models of care that broaden stroke nurses' scope of practice to maximise rt-PA treatment rates for ischaemic stroke patients are needed.
RELEVANCE TO CLINICAL PRACTICE CONCLUSIONS
This study demonstrates that UK and Australian nurses play an important role in thrombolysis practices; however, they are underused. Formalising and extending the role of stroke nurses in rt-PA administration could potentially increase thrombolysis rates with clinical benefits for patients.

Identifiants

pubmed: 34075640
doi: 10.1111/jocn.15892
doi:

Substances chimiques

Fibrinolytic Agents 0
Tissue Plasminogen Activator EC 3.4.21.68

Types de publication

Journal Article

Langues

eng

Pagination

158-166

Informations de copyright

© 2021 John Wiley & Sons Ltd.

Références

Aguiar de Sousa, D., von Martial, R., Abilleira, S., Gattringer, T., Kobayashi, A., Gallofré, M., Fazekas, F., Szikora, I., Feigin, V., Caso, V., & Fischer, U. (2018). Access to and delivery of acute ischaemic stroke treatments: A survey of national scientific societies and stroke experts in 44 European countries. European Stroke Journal, 4, 13-28. https://doi.org/10.1177/2396987318786023
Australian Commission on Safety and Quality in Health Care. (2017). Economic evaluation of investigator-initiated clinical trials conducted by networks. https://www.safetyandquality.gov.au/publications/economic-evaluation-of-investigator-initiated-clinical-trials-conducted-by-networks/. Accessed 30 June.
Barclay, J., & Jones, D. (2018). Stroke 4: Immediate treatment of acute stroke and TIA. Nursing Times [Online], 114(2), 51-54.
Birks, M., Davis, J., Smithson, J., & Cant, R. (2016). Registered nurse scope of practice in Australia: An integrative review of the literature. Contemporary Nurse, 52(5), 522-543. https://doi.org/10.1080/10376178.2016.1238773
Brethour, M. K., Nyström, K. V., Broughton, S., Kiernan, T. E., Perez, A., Handler, D., & Alexandrov, A. W. (2012). Controversies in acute stroke treatment. AACN Advanced Critical Care, 23(2), 158-172. https://doi.org/10.4037/NCI.0b013e31824fe1b6
Calderon, V. J., Kasturiarachi, B. M., Lin, E., Bansal, V., & Zaidat, O. O. (2018). Review of the mobile stroke unit experience worldwide. Interventional Neurology, 7(6), 347-358. https://doi.org/10.1159/000487334
Campbell, B. C. V., Ma, H., Ringleb, P. A., Parsons, M. W., Churilov, L., Bendszus, M., Levi, C. R., Hsu, C., Kleinig, T. J., Fatar, M., Leys, D., Molina, C., Wijeratne, T., Curtze, S., Dewey, H. M., Barber, P. A., Butcher, K. S., De Silva, D. A., Bladin, C. F., … on behalf of the EXTEND, ECASS-4, and EPITHET Investigators. (2019). Extending thrombolysis to 4·5-9 h and wake-up stroke using perfusion imaging: A systematic review and meta-analysis of individual patient data. The Lancet, 394(10193), 139-147. https://doi.org/10.1016/S0140-6736(19)31053-0
Candelaresi, P., Lattuada, P., Uggetti, C., Daccò, R., Fontana, G., & Frediani, F. (2017). A high-urgency stroke code reduces in-hospital delays in acute ischemic stroke: A single-centre experience. Neurological Sciences, 38(9), 1671-1676. https://doi.org/10.1007/s10072-017-3046-y
Catangui, E. (2013). The nursing role in thrombolysis treatment for acute ischaemic stroke: An overview. British Journal of Neuroscience Nursing, 9(2), 71-75. https://doi.org/10.12968/bjnn.2013.9.2.71
Catangui, E. J., & Roberts, C. J. (2014). The lived experiences of nurses in one hyper-acute stroke unit. British Journal of Nursing, 23(3), 143-148. https://doi.org/10.12968/bjon.2014.23.3.143
Cook, J. V., Dickinson, H. O., & Eccles, M. P. (2009). Response rates in postal surveys of healthcare professionals between 1996 and 2005: an observational study. BMC Health Services Research, 9(1), 160. https://doi.org/10.1186/1472-6963-9-160
Craig, L. E., Middleton, S., Hamilton, H., Cudlip, F., Swatzell, V., Alexandrov, A. V., Lightbody, E., Watkins, D. C., Philip, S., Cadilhac, D. A., McInnes, E., Dale, S., & Alexandrov, A. W. (2019). Does the addition of non-approved inclusion and exclusion criteria for rtPA impact treatment rates? Findings in Australia, the UK, and the USA. Interventional Neurology, 8(1), 1-12. https://doi.org/10.1159/000493020
Ehlers, L., Groth Jensen, L., Bech, M., Andersen, G., & Kjølby, M. (2007). Organisational barriers to thrombolysis treatment of acute ischaemic stroke. Current Medical Research and Opinion, 23(11), 2833-2839. https://doi.org/10.1185/030079907X242557
Emberson, J., Lees, K. R., Lyden, P., Blackwell, L., Albers, G., Bluhmki, E., Brott, T., Cohen, G., Davis, S., Donnan, G., Grotta, J., Howard, G., Kaste, M., Koga, M., von Kummer, R., Lansberg, M., Lindley, R. I., Murray, G., Olivot, J. M., … for the Stroke Thrombolysis Trialists' Collaborative Group. (2014). Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: A meta-analysis of individual patient data from randomised trials. The Lancet, 384, 1929-1935. https://doi.org/10.1016/S0140-6736(14)60584-5
Fassbender, K., Grotta, J. C., Walter, S., Grunwald, I. Q., Ragoschke-Schumm, A., & Saver, J. L. (2017). Mobile stroke units for prehospital thrombolysis, triage, and beyond: Benefits and challenges. The Lancet Neurology, 16(3), 227-237. https://doi.org/10.1016/S1474-4422(17)30008-X
Fitzpatrick, M., & Birns, J. (2004). Thrombolysis for acute ischaemic stroke and the role of the nurse. British Journal of Nursing, 13(20), 1170-1174. https://doi.org/10.12968/bjon.2004.13.20.17005
Fonarow, G. C., Smith, E. E., Saver, J. L., Reeves, M. J., Hernandez, A. F., Peterson, E. D., Sacco, R. L., & Schwamm, L. H. (2011). Improving door-to-needle times in acute ischemic stroke: the design and rationale for the American Heart Association/American Stroke Association's Target: Stroke initiative. Stroke, 42(10), 2983-2989. https://doi.org/10.1161/STROKEAHA.111.621342
Goyal, M., Demchuk, A. M., Menon, B. K., Eesa, M., Rempel, J. L., Thornton, J., Roy, D., Jovin, T. G., Willinsky, R. A., Sapkota, B. L., Dowlatshahi, D., Frei, D. F., Kamal, N. R., Montanera, W. J., Poppe, A. Y., Ryckborst, K. J., Silver, F. L., Shuaib, A., Tampieri, D., … Hill, M. D. (2015). Randomized assessment of rapid endovascular treatment of ischemic stroke. New England Journal of Medicine, 372(11), 1019-1030. https://doi.org/10.1056/NEJMoa1414905
Hacke, W., Kaste, M., Bluhmki, E., Brozman, M., Dávalos, A., Guidetti, D., Larrue, V., Lees, K. R., Medeghri, Z., Machnig, T., Schneider, D., von Kummer, R., Wahlgren, N., & Toni, D. (2008). Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. New England Journal of Medicine, 359(13), 1317-1329. https://doi.org/10.1056/NEJMoa0804656
Hargis, M., Shah, J. N., Mazabob, J., Rao, C. V., Suarez, J. I., & Bershad, E. M. (2015). Barriers to administering intravenous tissue plasminogen activator (tPA) for acute ischemic stroke in the emergency department: A cross-sectional survey of stroke centers. Clinical Neurology and Neurosurgery, 135, 79-84. https://doi.org/10.1016/j.clineuro.2015.04.027
Hoffman, J. R. (2003). Tissue plasminogen activator (tPA) for acute ischaemic stroke: Why so much has been made of so little. The Medical Journal of Australia, 179(7), 333-334. https://doi.org/10.5694/j.1326-5377.2003.tb05584.x
Kassardjian, C. D., Willems, J. D., Skrabka, K., Nisenbaum, R., Barnaby, J., Kostyrko, P., Selchen, D., & Saposnik, G. (2017). In-patient code stroke. Stroke, 48(8), 2176-2183. https://doi.org/10.1161/STROKEAHA.117.017622
King's College London. (2018). Sentinel Stroke National Audit Programme (Accessed 2018). https://www.strokeaudit.org/Home.aspx
Kwan, J., Hand, P., & Sandercock, P. (2004). A systematic review of barriers to delivery of thrombolysis for acute stroke. [Review] [67 refs]. Age and Ageing, 33(2), 116-121. https://doi.org/10.1093/ageing/afh064
McInnes, E., Dale, S., Craig, L., Phillips, R., Fasugba, O., Schadewaldt, V., Cheung, N. W., Cadilhac, D. A., Grimshaw, J. M., Levi, C., Considine, J., McElduff, P., Gerraty, R., Fitzgerald, M., Ward, J., D'Este, C., & Middleton, S. (2020). Process evaluation of an implementation trial to improve the triage, treatment and transfer of stroke patients in emergency departments (T3 trial): A qualitative study. Implementation Science, 15(1), 99. https://doi.org/10.1186/s13012-020-01057-0
Meretoja, A., Keshtkaran, M., Saver, J. L., Tatlisumak, T., Parsons, M. W., Kaste, M., Davis, S. M., Donnan, G. A., & Churilov, L. (2014). Stroke thrombolysis: Save a minute, save a day. Stroke, 45(4), 1053-1058. https://doi.org/10.1161/strokeaha.113.002910
Meretoja, A., Strbian, D., Mustanoja, S., Tatlisumak, T., Lindsberg, P. J., & Kaste, M. (2012). Reducing in-hospital delay to 20 minutes in stroke thrombolysis. Neurology, 79, 306-313. https://doi.org/10.1212/WNL.0b013e31825d6011
Meretoja, A., Weir, L., Ugalde, M., Yassi, N., Yan, B., Hand, P., Truesdale, M., Davis, S. M., & Campbell, B. C. V. (2013). Helsinki model cut stroke thrombolysis delays to 25 minutes in Melbourne in only 4 months. Neurology, 81(12), 1071-1076. https://doi.org/10.1212/WNL.0b013e3182a4a4d2
Middleton, S., Alexandrov, A. W., & Grimley, R. (2015). Triage, treatment, and transfer Evidence-based clinical practice recommendations and models of nursing care for the first 72 hours of admission to hospital for acute stroke. Stroke, 46, e18-e25. https://doi.org/10.1161/STROKEAHA.114.006139
Middleton, S., Dale, S., Cheung, N. W., Cadilhac, D. A., Grimshaw, J. M., Levi, C., McInnes, E., Considine, J., McElduff, P., Gerraty, R., Craig, L. E., Schadewaldt, V., Fitzgerald, M., Quinn, C., Cadigan, G., Denisenko, S., Longworth, M., Ward, J., D'Este, C., … on behalf of the T3 Collaborators. (2019). Nurse-initiated acute stroke care in emergency departments. The triage, treatment and transfer implementation cluser randomized controlled trial. Stroke, 50(6), 1346-1355. https://doi.org/10.1161/STROKEAHA.118.020701
Middleton, S., McElduff, P., Ward, J., Grimshaw, J., Dale, S., D'Este, C., Drury, P., Griffiths, R., Cheung, N. W., Quinn, C., Evans, M., Cadilhac, D., & Levi, C.; QASC Trialists Group. (2011). Implementation of evidence-based treatment protocols to manage fever, hyperglycaemia, and swallowing dysfunction in acute stroke (QASC): A cluster randomised controlled trial. Lancet, 378(9804), 1699-1706
Moran, J. L., Nakagawa, K., Asai, S. M., & Koenig, M. A. (2016). 24/7 neurocritical care nurse practitioner coverage reduced door-to-needle time in stroke patients treated with tissue plasminogen activator. Journal of Stroke and Cerebrovascular Diseases, 25(5), 1148-1152. https://doi.org/10.1016/j.jstrokecerebrovasdis.2016.01.033
National Stroke Foundation. (2015). National Stroke Audit - Acute Services Report.
Parker, S. A., Bowry, R., Wu, T.-C., Noser, E. A., Jackson, K., Richardson, L., Persse, D., & Grotta, J. C. (2015). Establishing the first mobile stroke unit in the United States. Stroke, 46(5), 1384-1391. https://doi.org/10.1161/STROKEAHA.114.007993
Paul, C. L., Ryan, A., Rose, S., Attia, J. R., Kerr, E., Koller, C., & Levi, C. R. (2016). How can we improve stroke thrombolysis rates? A review of health system factors and approaches associated with thrombolysis administration rates in acute stroke care. Implementation Science, 11(1), 51. https://doi.org/10.1186/s13012-016-0414-6
Puthenpurakal, A., & Crussell, J. (2017). Stroke 1: definition, burden, risk factors and diagnosis. Nursing Times, 113(11), 43-47
Saver, J. L., Fonarow, G. C., Smith, E. E., Reeves, M. J., Grau-Sepulveda, M. V., Pan, W., Olson, D. W. M., Hernandez, A. F., Peterson, E. D., & Schwamm, L. H. (2013). Time to treatment with intravenous tissue plasminogen activator and outcome from acute ischemic stroke. JAMA, 309(23), 2480-2488. https://doi.org/10.1001/jama.2013.6959
StataCorp. (2015). Stata Statistical Software: Release 14. StataCorp LP.
Stroke Foundation. (2019). National Stroke Audit - Acute Services Report 2019. Stroke Foundation.
Stroke Unit Trialists' Collaboration. (2013). Organised inpatient (stroke unit) care for stroke. The Cochrane Database of Systematic Reviews, 9, CD000197.
Summers, D., Leonard, A., Wentworth, D., Saver, J. L., Simpson, J. O., Spilker, J. A., Hock, N., Miller, E., & Mitchell, P. H. (2009). Comprehensive overview of nursing and interdisciplinary care of the acute ischemic stroke patient: A scientific statement from the American Heart Association. Stroke, 40(8), 2911-2944. https://doi.org/10.1161/STROKEAHA.109.192362
The ATLANTIS, ECASS, and NINDS rt-PA Study Group Investigators. (2004). Association of outcome with early stroke treatment: Pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. The Lancet, 363(9411), 768-774. https://doi.org/10.1016/S0140-6736(04)15692-4
Thomalla, G., Simonsen, C. Z., Boutitie, F., Andersen, G., Berthezene, Y., Cheng, B., Cheripelli, B., Cho, T.-H., Fazekas, F., Fiehler, J., Ford, I., Galinovic, I., Gellissen, S., Golsari, A., Gregori, J., Günther, M., Guibernau, J., Häusler, K. G., Hennerici, M., … Gerloff, C. (2018). MRI-guided thrombolysis for stroke with unknown time of onset. New England Journal of Medicine, 379(7), 611-622. https://doi.org/10.1056/NEJMoa1804355
von Elm, E., Altman, D. G., Egger, M., Pocock, S. J., Gøtzsche, P. C., Vandenbroucke, J. P. (2007). The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement: Guidelines for Reporting Observational Studies. Annals of internal medicine,147(8), 573-577. https://doi.org/10.7326/0003-4819-147-8-200710160-00010
Walter, S., Kostopoulos, P., Haass, A., Keller, I., Lesmeister, M., Schlechtriemen, T., Roth, C., Papanagiotou, P., Grunwald, I., Schumacher, H., Helwig, S., Viera, J., Körner, H., Alexandrou, M., Yilmaz, U., Ziegler, K., Schmidt, K., Dabew, R., Kubulus, D., … Fassbender, K. (2012). Diagnosis and treatment of patients with stroke in a mobile stroke unit versus in hospital: A randomised controlled trial. The Lancet Neurology, 11(5), 397-404. https://doi.org/10.1016/S1474-4422(12)70057-1
Wardlaw, J. M., Murray, V., Berge, E., del Zoppo, G., Sandercock, P., Lindley, R. L., & Cohen, G. (2012). Recombinant tissue plasminogen activator for acute ischaemic stroke: An updated systematic review and meta-analysis. The Lancet, 379(9834), 2364-2372. https://doi.org/10.1016/S0140-6736(12)60738-7
Wojner Alexandrov, A. W., Brethour, M., Cudlip, F., Swatzell, V., Biby, S., Reiner, D., Kiernan, T.-E., Handler, D., Tocco, S., & Yang, J. (2009). Postgraduate fellowship education and training for nurses: The NET SMART experience. Critical Care Nursing Clinics of North America, 21(4), 435-449. https://doi.org/10.1016/j.ccell.2009.09.001

Auteurs

Helen Hamilton (H)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Simeon Dale (S)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Benjamin McElduff (B)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Louise E Craig (LE)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Oyebola Fasugba (O)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Elizabeth McInnes (E)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Anne W Alexandrov (AW)

College of Nursing, University of Tennessee Health Science Center, Memphis, TN, USA.

Dominique A Cadilhac (DA)

Stroke and Ageing Research, School of Clinical Sciences, Monash University, Clayton, VIC, Australia.
Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC, Australia.

Elizabeth Lightbody (E)

Faculty of Health and Care, University of Central Lancashire, Lancashire, UK.

Dame Caroline Watkins (DC)

Faculty of Health and Care, University of Central Lancashire, Lancashire, UK.

Sandy Middleton (S)

Nursing Research Institute, St Vincent's Health Network Sydney, St Vincent's Hospital Melbourne and Australian Catholic University, North Sydney, NSW, Australia.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH