Arginase inhibition by rhaponticin increases L-arginine concentration that contributes to Ca
Animals
Arginase
/ antagonists & inhibitors
Arginine
/ genetics
Calcium
/ metabolism
Cytosol
/ metabolism
Endothelial Cells
/ drug effects
Human Umbilical Vein Endothelial Cells
Humans
Inositol 1,4,5-Trisphosphate Receptors
/ genetics
Mice
Mice, Inbred C57BL
Mice, Knockout
Mitochondrial Proteins
/ metabolism
Nitric Oxide
/ metabolism
Nitric Oxide Synthase Type III
/ drug effects
Reactive Oxygen Species
/ metabolism
Signal Transduction
Stilbenes
/ metabolism
Journal
BMB reports
ISSN: 1976-670X
Titre abrégé: BMB Rep
Pays: Korea (South)
ID NLM: 101465334
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
received:
12
04
2021
pubmed:
4
6
2021
medline:
4
2
2022
entrez:
3
6
2021
Statut:
ppublish
Résumé
Although arginase primarily participates in the last reaction of the urea cycle, we have previously demonstrated that arginase II is an important cytosolic calcium regulator through spermine production in a p32-dependent manner. Here, we demonstrated that rhaponticin (RPT) is a novel medicinal-plant arginase inhibitor and investigated its mechanism of action on Ca
Substances chimiques
Inositol 1,4,5-Trisphosphate Receptors
0
Itpr1 protein, mouse
0
Mitochondrial Proteins
0
Reactive Oxygen Species
0
Stilbenes
0
Nitric Oxide
31C4KY9ESH
Arginine
94ZLA3W45F
Nitric Oxide Synthase Type III
EC 1.14.13.39
Nos3 protein, mouse
EC 1.14.13.39
Arginase
EC 3.5.3.1
rhapontin
K691M2Z08V
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
516-521Références
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