Infant gut microbiome composition is associated with non-social fear behavior in a pilot study.
Adult
Bacteroides
/ classification
Brain
/ physiology
Breast Feeding
Clostridiales
/ classification
Fear
/ psychology
Feces
/ microbiology
Female
Gastrointestinal Microbiome
/ genetics
Humans
Infant
Infant Formula
Longitudinal Studies
Male
Pilot Projects
RNA, Ribosomal, 16S
/ genetics
Veillonella
/ classification
Veillonellaceae
/ classification
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
02 06 2021
02 06 2021
Historique:
received:
06
06
2019
accepted:
19
04
2021
entrez:
3
6
2021
pubmed:
4
6
2021
medline:
12
6
2021
Statut:
epublish
Résumé
Experimental manipulation of gut microbes in animal models alters fear behavior and relevant neurocircuitry. In humans, the first year of life is a key period for brain development, the emergence of fearfulness, and the establishment of the gut microbiome. Variation in the infant gut microbiome has previously been linked to cognitive development, but its relationship with fear behavior and neurocircuitry is unknown. In this pilot study of 34 infants, we find that 1-year gut microbiome composition (Weighted Unifrac; lower abundance of Bacteroides, increased abundance of Veillonella, Dialister, and Clostridiales) is significantly associated with increased fear behavior during a non-social fear paradigm. Infants with increased richness and reduced evenness of the 1-month microbiome also display increased non-social fear. This study indicates associations of the human infant gut microbiome with fear behavior and possible relationships with fear-related brain structures on the basis of a small cohort. As such, it represents an important step in understanding the role of the gut microbiome in the development of human fear behaviors, but requires further validation with a larger number of participants.
Identifiants
pubmed: 34078892
doi: 10.1038/s41467-021-23281-y
pii: 10.1038/s41467-021-23281-y
pmc: PMC8172562
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3294Subventions
Organisme : NIMH NIH HHS
ID : R21 MH104330
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK034987
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH106440
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008719
Pays : United States
Organisme : NIMH NIH HHS
ID : R33 MH104330
Pays : United States
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