COVID-19 and stem cell transplantation; results from an EBMT and GETH multicenter prospective survey.
Adolescent
Adult
Aged
Aged, 80 and over
COVID-19
/ complications
Child
Child, Preschool
Female
Follow-Up Studies
Hematologic Neoplasms
/ epidemiology
Hematopoietic Stem Cell Transplantation
/ methods
Humans
Infant
Male
Middle Aged
Prognosis
Prospective Studies
SARS-CoV-2
/ isolation & purification
Survival Rate
Transplantation, Homologous
Young Adult
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
14
02
2021
accepted:
17
05
2021
revised:
10
05
2021
pubmed:
4
6
2021
medline:
9
10
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
This study reports on 382 COVID-19 patients having undergone allogeneic (n = 236) or autologous (n = 146) hematopoietic cell transplantation (HCT) reported to the European Society for Blood and Marrow Transplantation (EBMT) or to the Spanish Group of Hematopoietic Stem Cell Transplantation (GETH). The median age was 54.1 years (1.0-80.3) for allogeneic, and 60.6 years (7.7-81.6) for autologous HCT patients. The median time from HCT to COVID-19 was 15.8 months (0.2-292.7) in allogeneic and 24.6 months (-0.9 to 350.3) in autologous recipients. 83.5% developed lower respiratory tract disease and 22.5% were admitted to an ICU. Overall survival at 6 weeks from diagnosis was 77.9% and 72.1% in allogeneic and autologous recipients, respectively. Children had a survival of 93.4%. In multivariate analysis, older age (p = 0.02), need for ICU (p < 0.0001) and moderate/high immunodeficiency index (p = 0.04) increased the risk while better performance status (p = 0.001) decreased the risk for mortality. Other factors such as underlying diagnosis, time from HCT, GVHD, or ongoing immunosuppression did not significantly impact overall survival. We conclude that HCT patients are at high risk of developing LRTD, require admission to ICU, and have increased mortality in COVID-19.
Identifiants
pubmed: 34079042
doi: 10.1038/s41375-021-01302-5
pii: 10.1038/s41375-021-01302-5
pmc: PMC8171362
doi:
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
2885-2894Informations de copyright
© 2021. The Author(s).
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