NOTUM from Apc-mutant cells biases clonal competition to initiate cancer.
Adenoma
/ genetics
Adenomatous Polyposis Coli Protein
/ genetics
Animals
Cell Competition
/ genetics
Cell Differentiation
Cell Proliferation
Cell Transformation, Neoplastic
/ genetics
Colorectal Neoplasms
/ genetics
Culture Media, Conditioned
Disease Progression
Esterases
/ antagonists & inhibitors
Female
Genes, APC
Humans
Ligands
Male
Mice
Mice, Inbred C57BL
Mutation
Organoids
/ cytology
Stem Cells
/ cytology
Wnt Proteins
/ metabolism
Wnt Signaling Pathway
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
03
2020
accepted:
07
04
2021
pubmed:
4
6
2021
medline:
6
10
2021
entrez:
3
6
2021
Statut:
ppublish
Résumé
The tumour suppressor APC is the most commonly mutated gene in colorectal cancer. Loss of Apc in intestinal stem cells drives the formation of adenomas in mice via increased WNT signalling
Identifiants
pubmed: 34079124
doi: 10.1038/s41586-021-03525-z
pii: 10.1038/s41586-021-03525-z
pmc: PMC7615049
mid: EMS186856
doi:
Substances chimiques
Adenomatous Polyposis Coli Protein
0
Culture Media, Conditioned
0
Ligands
0
Wnt Proteins
0
adenomatous polyposis coli protein, mouse
0
Esterases
EC 3.1.-
Notum protein, human
EC 3.1.1.-
Notum protein, mouse
EC 3.1.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
430-435Subventions
Organisme : Wellcome Trust
ID : FC001204
Pays : United Kingdom
Organisme : Medical Research Council
ID : FC001204
Pays : United Kingdom
Organisme : Wellcome Trust
ID : FC001002
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206341/Z/17/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206314/Z/17/Z
Pays : United Kingdom
Organisme : Cancer Research UK
ID : FC001204
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R017247/1
Pays : United Kingdom
Organisme : Arthritis Research UK
ID : FC001002
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Type : CommentIn
Type : CommentIn
Type : CommentIn
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