Cross-Diagnosis Structural Correlates of Autistic-Like Social Communication Differences.
attention-deficit/hyperactivity disorder
autism spectrum disorder
obsessive–compulsive disorder
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
01 10 2021
01 10 2021
Historique:
received:
11
01
2021
revised:
10
04
2021
accepted:
27
04
2021
pubmed:
4
6
2021
medline:
1
4
2022
entrez:
3
6
2021
Statut:
ppublish
Résumé
Social communication differences are seen in autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and obsessive-compulsive disorder (OCD), but the brain mechanisms contributing to these differences remain largely unknown. To address this gap, we used a data-driven and diagnosis-agnostic approach to discover brain correlates of social communication differences in ASD, ADHD, and OCD, and subgroups of individuals who share similar patterns of brain-behavior associations. A machine learning pipeline (regression clustering) was used to discover the pattern of association between structural brain measures (volume, surface area, and cortical thickness) and social communication abilities. Participants (n = 416) included children with a diagnosis of ASD (n = 192, age = 12.0[5.6], 19% female), ADHD (n = 109, age = 11.1[4.1], 18% female), or OCD (n = 50, age = 12.3[4.2], 42% female), and typically developing controls (n = 65, age = 11.6[7.1], 48% female). The analyses revealed (1) associations with social communication abilities in distributed cortical and subcortical networks implicated in social behaviors, language, attention, memory, and executive functions, and (2) three data-driven, diagnosis-agnostic subgroups based on the patterns of association in the above networks. Our results suggest that different brain networks may contribute to social communication differences in subgroups that are not diagnosis-specific.
Identifiants
pubmed: 34080611
pii: 6291515
doi: 10.1093/cercor/bhab142
pmc: PMC8491692
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5067-5076Subventions
Organisme : New Frontiers in Research Fund
ID : NFRFE-2018-00482
Organisme : Ontario Brain Institute
ID : IDS-11-02
Informations de copyright
© The Author(s) 2021. Published by Oxford University Press.
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